Search Results - "Mechetner, E"

Role of P-glycoprotein in evolution of populations of chronic myeloid leukemia cells treated with imatinib by Stromskaya, T. P, Rybalkina, E. Yu, Kruglov, S. S, Zabotina, T. N, Mechetner, E. B, Turkina, A. G, Stavrovskaya, A. A

“…Imatinib mesylate (imatinib) is a new generation preparation that is now successfully used for treatment of cancer, particularly for chemotherapy of chronic…”
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Expression and Activity of the Multidrug Resistance P-Glycoprotein in Human Peripheral Blood Lymphocytes by Chaudhary, Preet M., Mechetner, Eugene B., Roninson, Igor B.

“…P-glycoprotein (P-gp), the product of the MDR1 (multidrug resistance) gene, is a transmembrane efflux pump for different lipophilic compounds, including many…”
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Levels of multidrug resistance (MDR1) P-glycoprotein expression by human breast cancer correlate with in vitro resistance to taxol and doxorubicin by MECHETNER, E, KYSHTOOBAYEVA, A, ZONIS, S, HUN KIM, STROUP, R, GARCIA, R, PARKER, R. J, FRUEHAUF, J. P

“…To determine whether multidrug resistance (MDR1) P-glycoprotein (Pgp) expression correlated with clinical MDR1-related drug resistance, we established a…”
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A new method for quantitative assessment of P-glycoprotein-related multidrug resistance in tumour cells by HOMOLYA, L, HOLLO, Z, MÜLLER, M, MECHETNER, E. B, SARKADI, B

“…A rapid, functional and quantitative diagnostic method for the estimation of the P-glycoprotein (P-gp)-dependent multidrug resistance is required in the…”
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Role of P-glycoprotein in evolution of populations of chronic myeloid leukemia cells treated with imatinib by Stromskaya, T P, Rybalkina, E Yu, Kruglov, S S, Zabotina, T N, Mechetner, E B, Turkina, A G, Stavrovskaya, A A

“…Imatinib mesylate (imatinib) is a new generation preparation that is now successfully used for treatment of cancer, particularly for chemotherapy of chronic…”
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Altered expression of the MYCN oncogene modulates MRP gene expression and response to cytotoxic drugs in neuroblastoma cells by HABER, M, BORDOW, S. B, SALWEN, H, SCHMIDT, M. L, NORRIS, M. D, GILBERT, J, MADAFIGLIO, J, KAVALLARIS, M, MARSHALL, G. M, MECHETNER, E. B, FRUEHAUF, J. P, TEE, L, COHN, S. L

“…We have recently shown a close correlation between expression of the Multidrug Resistance-associated Protein (MRP) gene and the MYCN oncogene and provided…”
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Results of MDR-1 Vector Modification Trial Indicate that Granulocyte/Macrophage Colony-Forming Unit Cells Do not Contribute to Posttransplant Hematopoietic Recovery Following Intensive Systemic Therapy by Hanania, E. G., Giles, R. E., Kavanagh, J., Ellerson, D., Zu, Z., Wang, T., Su, Y., Kudelka, A., Rahman, Z., Holmes, F., Hortobagyi, G., Claxton, D., Bachier, C., Thall, P., Cheng, S., Hester, J., Ostrove, J. M., Bird, R. E., Chang, A., Korbling, M., Seong, D., Cote, R., Holzmayer, T., Mechetner, E., Heimfeld, S., Berenson, R., Burtness, B., Edwards, C., Bast, R., Andreeff, M., Champlin, R., Deisseroth, A. B.

“…To formally test the hypothesis that the granulocyte/macrophage colony-forming unit (GM-CFU) cells can contribute to early hematopoietic reconstitution…”
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Efficient Inhibition of P-Glycoprotein-Mediated Multidrug Resistance with a Monoclonal Antibody by Mechetner, Eugene B., Roninson, Igor B.

“…P-glycoprotein (Pgp), encoded by the MDR1 gene, is an active efflux pump for many structurally diverse lipophilic compounds. Cellular expression of Pgp results…”
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Biomarker and in Vitro Chemoresistance Profiles of Undifferentiated Ovarian Cancers by Chan, J.K, Kapp, D.S, Mechetner, E, Yu, I.R

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Monoclonal antibodies against P-glycoprotein, an MDR1 gene product, inhibit interleukin-2 release from PHA-activated lymphocytes by Raghu, G, Park, S W, Roninson, I B, Mechetner, E B

“…P-glycoprotein (Pgp), a product of the human MDR1 gene, is a member of the ABC superfamily of transporters responsible for the trafficking of biologically…”
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P-Glycoprotein Confers Methotrexate Resistance in 3T6 Cells with Deficient Carrier-Mediated Methotrexate Uptake by De Graaf, David, Sharma, Rakesh C., Mechetner, Eugene B., Schimke, Robert T., Roninson, Igor B.

“…P-glycoprotein (Pgp), a transmembrane efflux pump encoded by the MDR1 gene, transports various lipophilic drugs that enter the cell by passive diffusion…”
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Intracellular localization and content of YB-1 protein in multidrug resistant tumor cells by Vaiman, A V, Stromskaya, T P, Rybalkina, E Yu, Sorokin, A V, Guryanov, S G, Zabotina, T N, Mechetner, E B, Ovchinnikov, L P, Stavrovskaya, A A

“…The multifunctional mammalian protein YB-1 is a member of the large DNA- and RNA-binding protein family with an evolutionarily ancient cold-shock domain. YB-1…”
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Involvement of MDR1 P‐glycoprotein in multifactorial resistance to methotrexate by Norris, Murray D., Graaf, David De, Haber, Michelle, Kavallaris, Maria, Madafiglio, Janice, Gilbert, Jayne, Kwan, Edward, Stewart, Bernard W., Mechetner, Eugene B., Gudkov, Andrei V., Roninson, Igor B.

“…Cellular resistance to methotrexate (MTX) is believed to be unaffected by expression of MDRI P‐glycoprotein (Pgp), a pleiotropic efflux pump acting on…”
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Evaluation of newer prognostic markers for adult soft tissue sarcomas by Levine, E A, Holzmayer, T, Bacus, S, Mechetner, E, Mera, R, Bolliger, C, Roninson, I B, Das Gupta, T K

“…In addition to tumor size, grade, location, and the presence of metastases, other factors may be useful in prognostication for adults with soft tissue sarcoma…”
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P-Glycoprotein Function Involves Conformational Transitions Detectable by Differential Immunoreactivity by Mechetner, Eugene B., Schott, Brigitte, Morse, Brian S., Stein, Wilfred D., Druley, Todd, Davis, Kenneth A., Tsuruo, Takashi, Roninson, Igor B.

“…The MDR1 P-glycoprotein (Pgp), a member of the ATP-binding cassette family of transporters, is a transmembrane ATPase efflux pump for various lipophilic…”
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The multidrug resistance phenotype confers immunological resistance by Weisburg, J H, Curcio, M, Caron, P C, Raghu, G, Mechetner, E B, Roepe, P D, Scheinberg, D A

“…Multidrug resistance (MDR), which is due, in part, to the overexpression of P-glycoprotein, confers resistance to a variety of natural product chemotherapeutic…”
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Overexpression of P-glycoprotein is associated with a decreased mitochondrial transmembrane potential in doxorubicin-selected K562 human leukemia cells by Shtil, A A, Grinchuk, T M, Tee, L, Mechetner, E B, Ignatova, T N

“…We tested the hypothesis of whether overexpression of P-glycoprotein (Pgp) could be coupled with changes in specific mechanisms of antioxidant defense (in…”
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Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein by Schinkel, A H, Arceci, R J, Smit, J J, Wagenaar, E, Baas, F, Dollé, M, Tsuruo, T, Mechetner, E B, Roninson, I B, Borst, P

“…Monoclonal antibodies (MAbs) recognizing external epitopes of the human MDR1 P-glycoprotein have been used both for the detection of multidrug-resistant cells…”
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Determination of boron in tissues and cells using direct-current plasma atomic emission spectroscopy by Barth, Rolf F, Adams, Dianne M, Soloway, Albert H, Mechetner, Eugene B, Alam, Fazlul, Anisuzzaman, Abul K. M

“…We have developed a safe, simple, and efficient method for boron determination by means of direct-current plasma atomic emission spectroscopy. Tissues were…”
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Evidence for Multidrug Resistance-1 P-Glycoprotein-dependent Regulation of Cellular ATP Permeability by Roman, R. M., Lomri, N., Braunstein, G., Feranchak, A. P., Simeoni, L. A., Davison, A. K., Mechetner, E., Schwiebert, E. M., Fitz, J. G.

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