Search Results - "Mechawar, N"

Neuropathology of mood disorders: do we see the stigmata of inflammation? by Mechawar, N, Savitz, J

“…A proportion of cases with mood disorders have elevated inflammatory markers in the blood that conceivably may result from stress, infection and/or…”
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Neuropathology of suicide: recent findings and future directions by Lutz, P-E, Mechawar, N, Turecki, G

“…Suicide is a major public health concern and a leading cause of death in most societies. Suicidal behaviour is complex and heterogeneous, likely resulting from…”
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Astrocytic abnormalities and global DNA methylation patterns in depression and suicide by Nagy, C, Suderman, M, Yang, J, Szyf, M, Mechawar, N, Ernst, C, Turecki, G

“…Astrocytes are glial cells specific to the central nervous system and involved in numerous brain functions, including regulation of synaptic transmission and…”
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Glial fibrillary acidic protein is differentially expressed across cortical and subcortical regions in healthy brains and downregulated in the thalamus and caudate nucleus of depressed suicides by Torres-Platas, S G, Nagy, C, Wakid, M, Turecki, G, Mechawar, N

“…There is mounting evidence to suggest aberrant astrocytic function in depression and suicide. Independent studies have reported astrocytic abnormalities in…”
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Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review by Trépanier, M O, Hopperton, K E, Mizrahi, R, Mechawar, N, Bazinet, R P

“…Schizophrenia is a psychiatric disorder which has a lifetime prevalence of ~1%. Multiple candidate mechanisms have been proposed in the pathogenesis of…”
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Child abuse associates with an imbalance of oligodendrocyte-lineage cells in ventromedial prefrontal white matter by Tanti, A, Kim, J J, Wakid, M, Davoli, M-A, Turecki, G, Mechawar, N

“…Child abuse (CA) is a major risk factor for depression, and strongly associates with suicidal behavior during adulthood. Neuroimaging studies have reported…”
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MicroRNA regulation of central glial cell line-derived neurotrophic factor (GDNF) signalling in depression by Maheu, M, Lopez, J P, Crapper, L, Davoli, M A, Turecki, G, Mechawar, N

“…Although multiple studies have reported that peripheral glial cell line-derived neurotrophic factor (GDNF) is reduced in depression, cerebral GDNF signalling…”
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Neuropeptide and Small Transmitter Coexistence: Fundamental Studies and Relevance to Mental Illness by Hökfelt, Tomas, Barde, Swapnali, Xu, Zhi-Qing David, Kuteeva, Eugenia, Rüegg, Joelle, Le Maitre, Erwan, Risling, Mårten, Kehr, Jan, Ihnatko, Robert, Theodorsson, Elvar, Palkovits, Miklos, Deakin, William, Bagdy, Gyorgy, Juhasz, Gabriella, Prud'homme, H Josée, Mechawar, Naguib, Diaz-Heijtz, Rochellys, Ögren, Sven Ove

“…Neuropeptides are auxiliary messenger molecules that always co-exist in nerve cells with one or more small molecule (classic) neurotransmitters. Neuropeptides…”
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Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures by Moser, N, Mechawar, N, Jones, I, Gochberg-Sarver, A, Orr-Urtreger, A, Plomann, M, Salas, R, Molles, B, Marubio, L, Roth, U, Maskos, U, Winzer-Serhan, U, Bourgeois, J.-P, Le Sourd, A.-M, De Biasi, M, Schröder, H, Lindstrom, J, Maelicke, A, Changeux, J.-P, Wevers, A

“…Nicotinic acetylcholine receptors play important roles in numerous cognitive processes as well as in several debilitating central nervous system (CNS)…”
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Impaired structural hippocampal plasticity is associated with emotional and memory deficits in the olfactory bulbectomized rat by Morales-Medina, J.C, Juarez, I, Venancio-García, E, Cabrera, S.N, Menard, C, Yu, W, Flores, G, Mechawar, N, Quirion, R

“…Highlights ► OBX increases hyperlocomotion in the open field test. ► OBX induces immobility in the forced swim test. ► OBX disrupts spatial memory acquisition…”
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Disrupted hippocampal neuregulin-1/ErbB3 signaling and dentate gyrus granule cell alterations in suicide by Mahar, I, Labonte, B, Yogendran, S, Isingrini, E, Perret, L, Davoli, M A, Rachalski, A, Giros, B, Turecki, G, Mechawar, N

“…Neuregulin-1 (NRG1) and ErbB receptors have been associated with psychopathology, and NRG1-ErbB3 signaling has been shown to increase hippocampal neurogenesis…”
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Analysis of SNAP25 mRNA expression and promoter DNA methylation in brain areas of Alzheimer’s Disease patients by Furuya, T.K, Silva, P.N.O, Payão, S.L.M, Bertolucci, P.H.F, Rasmussen, L.T, De Labio, R.W, Braga, I.L.S, Chen, E.S, Turecki, G, Mechawar, N, Mill, J, Smith, M.A.C

“…Highlights ► Decrease in SNAP25 expression in brain areas of Alzheimer’s Disease in relation to elderly controls. ► SNAP25 mRNA expression alterations in brain…”
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The cholinergic innervation develops early and rapidly in the rat cerebral cortex: a quantitative immunocytochemical study by Mechawar, N, Descarries, L

“…A recently developed method for determining the length of cholinergic axons and number of cholinergic axon varicosities (terminals) in brain sections…”
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Disrupted hippocampal neuregulin-1/ErbB3 signaling and dentate gyrus granule cell alterations in suicide by Mahar, I, Labonte, B, Yogendran, S, Isingrini, E, Perret, L, Davoli, M A, Rachalski, A, Giros, B, Turecki, G, Mechawar, N

“…This corrects the article DOI: 10.1038/tp.2017.132…”
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Developmental profile of neuregulin receptor ErbB4 in postnatal rat cerebral cortex and hippocampus by Mechawar, N, Lacoste, B, Yu, W.-F, Srivastava, L.K, Quirion, R

“…Abstract We investigated the cellular and subcellular distributions of neuregulin tyrosine kinase receptor ErbB4 in the postnatal rat frontal cortex and…”
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Neuropathology of suicide: recent findings and future directions by Lutz, P-E, Mechawar, N, Turecki, G

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The neuropeptide landscape of human prefrontal cortex by Zhong, Wen, Barde, Swapnali, Mitsios, Nicholas, Adori, Csaba, Oksvold, Per, Feilitzen, Kalle von, O’Leary, Liam, Csiba, László, Hortobágyi, Tibor, Szocsics, Péter, Mechawar, Naguib, Maglóczky, Zsófia, Renner, Éva, Palkovits, Miklós, Uhlén, Mathias, Mulder, Jan, Hökfelt, Tomas

“…Human prefrontal cortex (hPFC) is a complex brain region involved in cognitive and emotional processes and several psychiatric disorders. Here, we present an…”
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Substance P, NPY, CCK and their receptors in five brain regions in major depressive disorder with transcriptomic analysis of locus coeruleus neurons by Barde, Swapnali, Aguila, Julio, Zhong, Wen, Solarz, Anna, Mei, Irene, Prud'homme, Josee, Palkovits, Miklos, Turecki, Gustavo, Mulder, Jan, Uhlén, Mathias, Nagy, Corina, Mechawar, Naguib, Hedlund, Eva, Hökfelt, Tomas

“…Major depressive disorder (MDD) is a serious disease and a burden to patients, families and society. Rodent experiments and human studies suggest that several…”
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Presence of Ras guanyl nucleotide-releasing protein in striosomes of the mature and developing rat by Pierret, P, Mechawar, N, Vallée, A, Patel, J, Priestley, J.V, Dunn, R.J, Dower, N.A, Stone, J.C, Richardson, P.M

“…Ras signal transduction pathways have been implicated as key regulators in neuroplasticity and synaptic transmission in the brain. These pathways can be…”
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Cellular and subcellular localization of Ras guanyl nucleotide-releasing protein in the rat hippocampus by Pierret, P, Vallée, A, Mechawar, N, Dower, N.A, Stone, J.C, Richardson, P.M, Dunn, R.J

“…Ras guanyl nucleotide-releasing protein (RasGRP) is a recently discovered Ras guanyl nucleotide exchange factor that is expressed in selected regions of the…”
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