Search Results - "Mechaly, Ariel E"

Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation by Mechaly, Ariel E, Sassoon, Nathalie, Betton, Jean-Michel, Alzari, Pedro M

“…Histidine kinases (HKs) are dimeric receptors that participate in most adaptive responses to environmental changes in prokaryotes. Although it is well…”
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High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur by Weber, Patrick, Pissis, Cédric, Navaza, Rafael, Mechaly, Ariel E, Saul, Frederick, Alzari, Pedro M, Haouz, Ahmed

“…The availability of whole-genome sequence data, made possible by significant advances in DNA sequencing technology, led to the emergence of structural genomics…”
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What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira by Fouts, Derrick E, Matthias, Michael A, Adhikarla, Haritha, Adler, Ben, Amorim-Santos, Luciane, Berg, Douglas E, Bulach, Dieter, Buschiazzo, Alejandro, Chang, Yung-Fu, Galloway, Renee L, Haake, David A, Haft, Daniel H, Hartskeerl, Rudy, Ko, Albert I, Levett, Paul N, Matsunaga, James, Mechaly, Ariel E, Monk, Jonathan M, Nascimento, Ana L T, Nelson, Karen E, Palsson, Bernhard, Peacock, Sharon J, Picardeau, Mathieu, Ricaldi, Jessica N, Thaipandungpanit, Janjira, Wunder, Jr, Elsio A, Yang, X Frank, Zhang, Jun-Jie, Vinetz, Joseph M

“…Leptospirosis, caused by spirochetes of the genus Leptospira, is a globally widespread, neglected and emerging zoonotic disease. While whole genome analysis of…”
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Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis by East, Alexandra, Mechaly, Ariel E., Huysmans, Gerard H.M., Bernarde, Cédric, Tello-Manigne, Diana, Nadeau, Nathalie, Pugsley, Anthony P., Buschiazzo, Alejandro, Alzari, Pedro M., Bond, Peter J., Francetic, Olivera

“…The Klebsiella lipoprotein pullulanase (PulA) is exported to the periplasm, triacylated, and anchored via lipids in the inner membrane (IM) prior to its…”
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Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action by Trajtenberg, Felipe, Imelio, Juan A, Machado, Matías R, Larrieux, Nicole, Marti, Marcelo A, Obal, Gonzalo, Mechaly, Ariel E, Buschiazzo, Alejandro

“…Two-component systems (TCS) are protein machineries that enable cells to respond to input signals. Histidine kinases (HK) are the sensory component,…”
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Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens by Grillová, Linda, Oppelt, Jan, Mikalová, Lenka, Nováková, Markéta, Giacani, Lorenzo, Niesnerová, Anežka, Noda, Angel A, Mechaly, Ariel E, Pospíšilová, Petra, Čejková, Darina, Grange, Philippe A, Dupin, Nicolas, Strnadel, Radim, Chen, Marcus, Denham, Ian, Arora, Natasha, Picardeau, Mathieu, Weston, Christopher, Forsyth, R Allyn, Šmajs, David

“…Syphilis, caused by subsp. (TPA), remains an important public health problem with an increasing worldwide prevalence. Despite recent advances in cultivation,…”
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Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins) by Correa, Agustín, Pacheco, Sabino, Mechaly, Ariel E, Obal, Gonzalo, Béhar, Ghislaine, Mouratou, Barbara, Oppezzo, Pablo, Alzari, Pedro M, Pecorari, Frédéric

“…Glycosidases are associated with various human diseases. The development of efficient and specific inhibitors may provide powerful tools to modulate their…”
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Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation by Trajtenberg, Felipe, Albanesi, Daniela, Ruétalo, Natalia, Botti, Horacio, Mechaly, Ariel E, Nieves, Marcos, Aguilar, Pablo S, Cybulski, Larisa, Larrieux, Nicole, de Mendoza, Diego, Buschiazzo, Alejandro

“…Response regulators are proteins that undergo transient phosphorylation, connecting specific signals to adaptive responses. Remarkably, the molecular mechanism…”
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Evidence of Alternative Splicing as a Regulatory Mechanism for Kissr2 in Pejerrey Fish by Mechaly, Alejandro S, Tovar Bohórquez, M Oswaldo, Mechaly, Ariel E, Suku, Eda, Pérez, María Rita, Giorgetti, Alejandro, Ortí, Guillermo, Viñas, Jordi, Somoza, Gustavo M

“…Kisspeptin receptors are G-Protein-Coupled Receptors that regulate GnRH synthesis and release in vertebrates. Here, we report the gene structure of two…”
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Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira by Adhikarla, Haritha, Wunder, Jr, Elsio A, Mechaly, Ariel E, Mehta, Sameet, Wang, Zheng, Santos, Luciane, Bisht, Vimla, Diggle, Peter, Murray, Gerald, Adler, Ben, Lopez, Francesc, Townsend, Jeffrey P, Groisman, Eduardo, Picardeau, Mathieu, Buschiazzo, Alejandro, Ko, Albert I

“…Leptospirosis is an emerging zoonotic disease with more than 1 million cases annually. Currently there is lack of evidence for signaling pathways involved…”
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Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis by Mechaly, Ariel E., Haouz, Ahmed, Miras, Isabelle, Barilone, Nathalie, Weber, Patrick, Shepard, William, Alzari, Pedro M., Bellinzoni, Marco

“…► M. tuberculosis fumarase complexes with l-malate, meso-tartrate or fumarate. ► First reported crystal structure of a fumarase in complex with fumarate. ►…”
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Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker by Cheung, Yee-Wai, Röthlisberger, Pascal, Mechaly, Ariel E., Weber, Patrick, Levi-Acobas, Fabienne, Lo, Young, Wong, Alvin W. C., Kinghorn, Andrew B., Haouz, Ahmed, Savage, G. Paul, Hollenstein, Marcel, Tanner, Julian A.

“…Nucleic acid aptamers selected through systematic evolution of ligands by exponential enrichment (SELEX) fold into exquisite globular structures in complex…”
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Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2 by Le Coadou, Louise, Berthelet, Jérémy, Mechaly, Ariel E, Michail, Christina, Bui, Linh-Chi, Dairou, Julien, Haouz, Ahmed, Dupret, Jean-Marie, Rodrigues Lima, Fernando

“…SETD2 (SET-domain containing protein 2) is a histone methyltransferase (HMT) of the SET family responsible for the trimethylation of K36 of histone H3, thus…”
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Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase by Mechaly, Ariel E., Soto Diaz, Silvia, Sassoon, Nathalie, Buschiazzo, Alejandro, Betton, Jean-Michel, Alzari, Pedro M.

“…Bacterial two-component systems consist of a sensor histidine kinase (HK) and a response regulator (RR). HKs are homodimers that catalyze the…”
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Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance by Mechaly, Ariel E., Haouz, Ahmed, Sassoon, Nathalie, Buschiazzo, Alejandro, Betton, Jean-Michel, Alzari, Pedro M.

“…The transcriptional regulator CpxR mediates an adaptive response to envelope stress, tightly linked to virulence and antibiotics resistance in several…”
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Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy by Nian, Qing, Berthelet, Jérémy, Parlato, Marianna, Mechaly, Ariel E., Liu, Rongxing, Dupret, Jean‐Marie, Cerf‐Bensussan, Nadine, Haouz, Ahmed, Rodrigues Lima, Fernando

“…PTPN2 is an important protein tyrosine phosphatase (PTP) that plays a key role in cell signaling. Deletions or inactivating mutations of PTPN2 have been…”
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Structural Insights into the Oligomerization and Architecture of Eukaryotic Membrane Pore-Forming Toxins by Mechaly, Ariel E., Bellomio, Augusto, Gil-Cartón, David, Morante, Koldo, Valle, Mikel, González-Mañas, Juan Manuel, Guérin, Diego M.A.

“…Pore-forming toxins (PFTs) are proteins that are secreted as soluble molecules and are inserted into membranes to form oligomeric transmembrane pores. In this…”
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Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis by San Martin, Fabiana, Mechaly, Ariel E., Larrieux, Nicole, Wunder, Elsio A., Ko, Albert I., Picardeau, Mathieu, Trajtenberg, Felipe, Buschiazzo, Alejandro

“…The protein FcpA is a unique component of the flagellar filament of spirochete bacteria belonging to the genus Leptospira. Although it plays an essential role…”
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Pores of the toxin FraC assemble into 2D hexagonal clusters in both crystal structures and model membranes by Mechaly, Ariel E., Bellomio, Augusto, Morante, Koldo, Agirre, Jon, Gil-Cartón, David, Valle, Mikel, González-Mañas, Juan Manuel, Guérin, Diego M.A.

“…The recent high-resolution structure of the toxin FraC derived from the sea anemone Actinia fragacea has provided new insight into the mechanism of pore…”
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Crystal structure of the temperature-sensitive and allosteric-defective chaperonin GroELE461K by Cabo-Bilbao, Aintzane, Spinelli, Silvia, Sot, Begoña, Agirre, Jon, Mechaly, Ariel E, Muga, Arturo, Guérin, Diego M A

“…The chaperonin GroEL adopts a double-ring structure with various modes of allosteric communication. The simultaneous positive intra-ring and negative…”
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