Search Results - "Meazza, Raffaella"

Analysis of memory-like natural killer cells in human cytomegalovirus-infected children undergoing αβ+T and B cell-depleted hematopoietic stem cell transplantation for hematological malignancies by Muccio, Letizia, Bertaina, Alice, Falco, Michela, Pende, Daniela, Meazza, Raffaella, Lopez-Botet, Miguel, Moretta, Lorenzo, Locatelli, Franco, Moretta, Alessandro, Della Chiesa, Mariella

“…We analyzed the impact of human cytomegalovirus infection on the development of natural killer cells in 27 pediatric patients affected by hematological…”
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A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes by Bryceson, Yenan T., Pende, Daniela, Maul-Pavicic, Andrea, Gilmour, Kimberly C., Ufheil, Heike, Vraetz, Thomas, Chiang, Samuel C., Marcenaro, Stefania, Meazza, Raffaella, Bondzio, Ilka, Walshe, Denise, Janka, Gritta, Lehmberg, Kai, Beutel, Karin, zur Stadt, Udo, Binder, Nadine, Arico, Maurizio, Moretta, Lorenzo, Henter, Jan-Inge, Ehl, Stephan

“…Familial hemophagocytic lymphohistiocytosis (FHL) is a life-threatening disorder of immune regulation caused by defects in lymphocyte cytotoxicity. Rapid…”
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Role of Common-Gamma Chain Cytokines in NK Cell Development and Function : Perspectives for Immunotherapy by Meazza, Raffaella, Azzarone, Bruno, Orengo, Anna Maria, Ferrini, Silvano

“…NK cells are components of the innate immunity system and play an important role as a first-line defense mechanism against viral infections and in tumor immune…”
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Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies by Marrella, Alessandra, Dondero, Alessandra, Aiello, Maurizio, Casu, Beatrice, Olive, Daniel, Regis, Stefano, Bottino, Cristina, Pende, Daniela, Meazza, Raffaella, Caluori, Guido, Castriconi, Roberta, Scaglione, Silvia

“…High risk Neuroblastoma (NB) includes aggressive, metastatic solid tumors of childhood. The survival rate improved only modestly, despite the use of…”
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Donor selection for adoptive immunotherapy with NK cells in AML patients: Comparison between analysis of lytic NK cell clones and phenotypical identification of alloreactive NK cell repertoire by Meazza, Raffaella, Ruggeri, Loredana, Guolo, Fabio, Minetto, Paola, Canevali, Paolo, Loiacono, Fabrizio, Ciardelli, Sara, Bo, Alessandra, Luchetti, Silvia, Serio, Alberto, Zannoni, Letizia, Retière, Christelle, Colomar-Carando, Natalia, Parisi, Sarah, Curti, Antonio, Lemoli, Roberto M, Pende, Daniela

“…Natural killer (NK) cell-based adoptive immunotherapy in leukemia patients is an emerging field of interest based on clinical evidence of efficacy and safety…”
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The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell activation and in the lysis of uninfected dendritic cells by Ferlazzo, Guido, Morandi, Barbara, D'Agostino, Antonella, Meazza, Raffaella, Melioli, Giovanni, Moretta, Alessandro, Moretta, Lorenzo

“…NK and DC reciprocal interactions have only recently been investigated. In this study, we focused on the interplay between NK cells and DC in two models of…”
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Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis by Meazza, Raffaella, PhD, Tuberosa, Claudia, PhD, Cetica, Valentina, PhD, Falco, Michela, PhD, Parolini, Silvia, PhD, Grieve, Sam, PhD, Griffiths, Gillian M., PhD, Sieni, Elena, MD, Marcenaro, Stefania, PhD, Micalizzi, Concetta, MD, Montin, Davide, MD, Fagioli, Franca, MD, Moretta, Alessandro, MD, Mingari, Maria C., PhD, Moretta, Lorenzo, MD, Notarangelo, Luigi D., MD, Bottino, Cristina, MD, Aricò, Maurizio, MD, Pende, Daniela, PhD

“…Background Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, heterogeneous, hyperinflammmatory disorder. Prompt identification of inherited forms…”
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Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells by de Totero, Daniela, Meazza, Raffaella, Zupo, Simona, Cutrona, Giovanna, Matis, Serena, Colombo, Monica, Balleari, Enrico, Pierri, Ivana, Fabbi, Marina, Capaia, Matteo, Azzarone, Bruno, Gobbi, Marco, Ferrarini, Manlio, Ferrini, Silvano

“…Interleukin-21 (IL-21) is a member of the IL-2 cytokine family, which mediates proliferation or growth arrest and apoptosis of normal B cells, depending on…”
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CIITA-Induced MHC Class II Expression in Mammary Adenocarcinoma Leads to a Th1 Polarization of the Tumor Microenvironment, Tumor Rejection, and Specific Antitumor Memory by MORTARA, Lorenzo, CASTELLANI, Patrizia, MEAZZA, Raffaella, TOSI, Giovanna, DE LERMA BARBARO, Andrea, PROCOPIO, Francesco A, COMES, Alberto, ZARDI, Luciano, FERRINI, Silvano, ACCOLLA, Roberto S

“…Purpose: We have shown previously that the MHC class II–negative murine TS/A adenocarcinoma is rejected in vivo if induced to express MHC class II molecules by…”
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N-803: a double-edged sword in haplo-NK therapy by Pende, Daniela, Meazza, Raffaella

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Tumor rejection by gene transfer of the MHC class II transactivator in murine mammary adenocarcinoma cells by Meazza, Raffaella, Comes, Alberto, Orengo, Anna M., Ferrini, Silvano, Accolla, Roberto S.

“…The murine mammary adenocarcinoma cell line TS/A is a highly malignant MHC class II‐negative tumor. We show that transfection of TS/A cells with the MHC class…”
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Inhibition of mammary carcinoma development in HER-2/neu transgenic mice through induction of autoimmunity by xenogeneic DNA vaccination by PUPA, Serenella M, IEZZI, Manuela, DI CARLO, Emma, INVERNIZZI, Annamaria, CAVALLO, Federica, MEAZZA, Raffaella, COMES, Alberto, FERRINI, Silvano, MUSIANI, Piero, MENARD, Sylvie

“…Plasmid DNA vectors encoding the full-length (VR1012/HER-2-FL) or only the extracellular and transmembrane domains (VR1012/HER-2-ECD-TM) of human (h) HER-2/neu…”
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Sequential Immunogene Therapy with Interleukin-12– and Interleukin-15–Engineered Neuroblastoma Cells Cures Metastatic Disease in Syngeneic Mice by CROCE, Michela, MEAZZA, Raffaella, CORRIAS, Maria Valeria, FERRINI, Silvano, ORENGO, Anna Maria, RADIC', Luana, DE GIOVANNI, Barbara, GAMBINI, Claudio, CARLINI, Barbara, PISTOIA, Vito, MORTARA, Lorenzo, ACCOLLA, Roberto S

“…Purpose: To investigate the potential synergistic effects of Neuro2a neuroblastoma cells engineered with IL-12 and/or IL-15 genes in improving survival of…”
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IL-15/IL-15Rα intracellular trafficking in human melanoma cells and signal transduction through the IL-15Rα by PERENO, Raffaele, GIRON-MICHEL, Julien, FERRINI, Silvano, AZZARONE, Bruno, GAGGERO, Alessia, CAZES, Eric, MEAZZA, Raffaella, MONETTI, Monia, MONACO, Eugenia, MISHAL, Zohar, JASMIN, Claude, INDIVERI, Francesco

“…There are two IL-15 isoforms and eight isoforms for the IL-15Rα chain whose biological role is poorly understood. Here, we have analysed the intracellular…”
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Different levels of control prevent interferon-γ-inducible HLA-class II expression in human neuroblastoma cells by CROCE, Michela, DE AMBROSIS, Alessandro, CORRIAS, Maria V, PISTOIA, Vito, OCCHINO, Marzia, MEAZZA, Raffaella, GIRON-MICHEL, Julien, AZZARONE, Bruno, ACCOLLA, Roberto S, FERRINI, Silvano

“…The HLA class II expression is controlled by the transcriptional activator CIITA. The transcription of CIITA is controlled by different promoters, among which…”
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γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ+/CD19+ lymphocytes by Airoldi, Irma, Bertaina, Alice, Prigione, Ignazia, Zorzoli, Alessia, Pagliara, Daria, Cocco, Claudia, Meazza, Raffaella, Loiacono, Fabrizio, Lucarelli, Barbarella, Bernardo, Maria Ester, Barbarito, Giulia, Pende, Daniela, Moretta, Alessandro, Pistoia, Vito, Moretta, Lorenzo, Locatelli, Franco

“…We prospectively assessed functional and phenotypic characteristics of γδ T lymphocytes up to 7 months after HLA-haploidentical hematopoietic stem cell…”
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Report from the Eleventh Killer Immunoglobulin‐like Receptor (KIR) Workshop: Novel insights on KIR polymorphism, ligand recognition, expression and function by Falco, Michela, Sivori, Simona, Meazza, Raffaella, Pende, Daniela

“…The Eleventh Killer Immunoglobulin‐like Receptor (KIR) Workshop was held in Camogli (Genoa, Italy) in October 2018. This congress brought together 113…”
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ERAP1 regulates natural killer cell function by controlling the engagement of inhibitory receptors by Cifaldi, Loredana, Romania, Paolo, Falco, Michela, Lorenzi, Silvia, Meazza, Raffaella, Petrini, Stefania, Andreani, Marco, Pende, Daniela, Locatelli, Franco, Fruci, Doriana

“…The endoplasmic reticulum aminopeptidase ERAP1 regulates innate and adaptive immune responses by trimming peptides for presentation by MHC class I (MHC-I)…”
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2B4 dysfunction in XLP1 NK cells: More than inability to control EBV infection by Pende, Daniela, Meazza, Raffaella, Marcenaro, Stefania, Aricò, Maurizio, Bottino, Cristina

“…X-linked lymphoproliferative disease 1 (XLP1) is a monogenic disorder caused by mutations in SH2D1A, resulting in the absence/dysfunction of the signaling…”
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NK Cell-Based Immunotherapy for Hematological Malignancies by Sivori, Simona, Meazza, Raffaella, Quintarelli, Concetta, Carlomagno, Simona, Della Chiesa, Mariella, Falco, Michela, Moretta, Lorenzo, Locatelli, Franco, Pende, Daniela

“…Natural killer (NK) lymphocytes are an integral component of the innate immune system and represent important effector cells in cancer immunotherapy,…”
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