Search Results - "Meares, Diane"

Transplanting FVIII/ET3-secreting cells in fetal sheep increases FVIII levels long-term without inducing immunity or toxicity by Rodriguez, Martin, Trevisan, Brady, Ramamurthy, Ritu M., George, Sunil K., Diaz, Jonathan, Alexander, Jordan, Meares, Diane, Schwahn, Denise J., Quilici, David R., Figueroa, Jorge, Gautreaux, Michael, Farland, Andrew, Atala, Anthony, Doering, Christopher B., Spencer, H. Trent, Porada, Christopher D., Almeida-Porada, Graça

“…Hemophilia A is the most common X-linked bleeding disorder affecting more than half-a-million individuals worldwide. Persons with severe hemophilia A have…”
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Comparison of different gene addition strategies to modify placental derived-mesenchymal stromal cells to produce FVIII by Ramamurthy, Ritu M, Rodriguez, Martin, Ainsworth, Hannah C, Shields, Jordan, Meares, Diane, Bishop, Colin, Farland, Andrew, Langefeld, Carl D, Atala, Anthony, Doering, Christopher B, Spencer, H Trent, Porada, Christopher D, Almeida-Porada, Graça

“…Placenta-derived mesenchymal cells (PLCs) endogenously produce FVIII, which makes them ideally suited for cell-based fVIII gene delivery. We have previously…”
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Defining the Optimal FVIII Transgene for Placental Cell-Based Gene Therapy to Treat Hemophilia A by El-Akabawy, Nadia, Rodriguez, Martin, Ramamurthy, Ritu, Rabah, Andrew, Trevisan, Brady, Morsi, Alshaimaa, George, Sunil, Shields, Jordan, Meares, Diane, Farland, Andrew, Atala, Anthony, Doering, Christopher B., Spencer, H. Trent, Porada, Christopher D., Almeida-Porada, Graça

“…The delivery of factor VIII (FVIII) through gene and/or cellular platforms has emerged as a promising hemophilia A treatment. Herein, we investigated the…”
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Investigating Optimal Autologous Cellular Platforms for Prenatal or Perinatal Factor VIII Delivery to Treat Hemophilia A by Stem, Christopher, Rodman, Christopher, Ramamurthy, Ritu M, George, Sunil, Meares, Diane, Farland, Andrew, Atala, Anthony, Doering, Christopher B, Spencer, H Trent, Porada, Christopher D, Almeida-Porada, Graça

“…Patients with the severe form of hemophilia A (HA) present with a severe phenotype, and can suffer from life-threatening, spontaneous hemorrhaging. While…”
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Effects of Shear Stress on Production of FVIII and vWF in a Cell-Based Therapeutic for Hemophilia A by Trevisan, Brady, Morsi, Alshaimaa, Aleman, Julio, Rodriguez, Martin, Shields, Jordan, Meares, Diane, Farland, Andrew M, Doering, Christopher B, Spencer, H Trent, Atala, Anthony, Skardal, Aleks, Porada, Christopher D, Almeida-Porada, Graça

“…Microfluidic technology enables recapitulation of organ-level physiology to answer pertinent questions regarding biological systems that otherwise would remain…”
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In Utero Transplantation of FVIII-Expressing Human Placental Cells Upregulates Gene Pathways Associated with Immune Tolerance, Altering the Response to Postnatal FVIII Infusion by Rodriguez, Martin, Trevisan, Brady, George, Sunil, Shields, Jordan E, Figueroa, Jorge, Meares, Diane, Owen, John, Atala, Anthony, Doering, Christopher B, Spencer, H. Trent, Porada, Christopher D, Almeida-Porada, M. Graca

“…We have previously reported that in utero transplantation (IUTx) of sheep fetuses (n=14) with human placental cells (PLC) transduced with a lentiviral vector…”
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Administration of Cells Engineered to Secrete Fviii-mcoET3 in Prenatal Sheep Recipients Results in Sustained Curative Fviii Plasma Levels for 3 Years after Birth, without Immune or Toxicity-Related Adverse Events by Rodriguez, Martin, Trevisan, Brady, George, Sunil, Ramamurthy, Ritu M, Rabah, Andrew, Shields, Jordan E, Schwahn, Denise, Figueroa, Jorge, Meares, Diane, Owen, John, Gautreaux, Michael, Atala, Anthony, Doering, Christopher B, Spencer, H. Trent, Porada, Christopher D, Almeida-Porada, M. Graca

“…The treatment of hemophilia A (HA) patients by prenatal transplantation (PNT) is a feasible, yet underestimated and unexplored clinical approach. The…”
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Delivery of Fviii-mcoET3 to Previously Untreated Sheep Using Human Placental Cells Enables Durable Elevation of Plasma FVIII Levels and Avoids Inhibitor Formation by Trevisan, Brady, Rodriguez, Martin, George, Sunil, Lankford, Shannon, Shields, Jordan E, Figueroa, Jorge, Meares, Diane, Owen, John, Atala, Anthony, Doering, Christopher B, Spencer, H. Trent, Porada, Christopher D, Almeida-Porada, M. Graca

“…Hemophilia A (HA) is characterized by a decrease in the functional clotting protein factor VIII (FVIII). Current hemophilia treatments consist of either…”
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Prenatal Transplantation of Placental Cells Engineered to Express FVIII Leads to Corrective Plasma Levels of FVIII after Birth by Almeida-Porada, M. Graca, George, Sunil, Morsi, Alshaima, El-Akabawy, Nadia, Figueroa, Jorge, Shields, Jordan E, Meares, Diane, Farland, Andrew M., Atala, Anthony, Doering, Christopher B, Spencer, H. Trent, Porada, Christopher D

“…Prenatal transplantation (PNTx) is a clinically viable procedure that has been performed in ~50 human patients for 14 different genetic disorders. When…”
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