Search Results - "Means, Gary D."

First‐in‐human study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALPN‐101, a dual CD28/ICOS antagonist, in healthy adult subjects by Yang, Jing, Lickliter, Jason D., Hillson, Jan L., Means, Gary D., Sanderson, Russell J., Carley, Kay, Tercero, Almudena, Manjarrez, Kristi L., Wiley, Jennifer R., Peng, Stanford L.

“…ALPN‐101 (ICOSL vIgD‐Fc) is an Fc fusion protein of a human inducible T cell costimulatory ligand (ICOSL) variant immunoglobulin domain (vIgD) designed to…”
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Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML by Laszlo, George S., Gudgeon, Chelsea J., Harrington, Kimberly H., Dell'Aringa, Justine, Newhall, Kathryn J., Means, Gary D., Sinclair, Angus M., Kischel, Roman, Frankel, Stanley R., Walter, Roland B.

“…CD33 is a valid target for acute myeloid leukemia (AML) but has proven challenging for antibody-drug conjugates. Herein, we investigated the cellular…”
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The evolution of tools for protein phosphorylation site analysis: from discovery to clinical application by Bonilla, Leo, Means, Gary, Lee, Kimberly, Patterson, Scott

“…The importance of the analysis of signaling pathways has been proven for many years by the elucidation of key signaling molecules. However, in most cases these…”
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Bridging the Divide between Manual Gating and Bioinformatics with the Bioconductor Package flowFlowJo by Gosink, John J., Means, Gary D., Rees, William A., Su, Cheng, Rand, Hugh A.

“…In flow cytometry, different cell types are usually selected or “gated” by a series of 1- or 2-dimensional geometric subsets of the measurements made on each…”
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Evidence for Endotoxin Contamination in Plastic Na+-Heparin Blood Collection Tube Lots by NEWHALL, Kathryn J, DIEMER, Geoffrey S, LESHINSKY, Natalia, KERKOF, Keith, CHUTE, Hilary T, RUSSELL, Chris B, REES, William, WELCHER, Andrew A, PATTERSON, Scott D, MEANS, Gary D

“…Biomarker assays are often conducted on whole blood samples in the course of drug development studies. Because bacterial lipopolysaccharide (LPS) (endotoxin)…”
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Tissue-specific promoters regulate aromatase cytochrome P450 gene expression in human ovary and fetal tissues by Means, G D, Kilgore, M W, Mahendroo, M S, Mendelson, C R, Simpson, E R

“…The formation of estrogens from C19 steroids is catalyzed by a specific form of cytochrome P450, aromatase cytochrome P450 (P450AROM; the product of the CYP19…”
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An Open Label Study of Alpn-101, a First-in-Class Dual CD28/ICOS Antagonist, in Subjects with Steroid-Resistant or Steroid-Refractory Acute Graft Versus Host Disease (aGVHD) by Yang, Jing, Hillson, Jan L., Manjarrez, Kristi L., Wiley, Jennifer R., Means, Gary D., Dillon, Stacey R., Peng, Stanford L.

“…Background: Cluster of differentiation 28 (CD28) and inducible T cell costimulator (ICOS) provide costimulatory signals required for optimal T cell activation…”
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A Transcript Map of a 2-Mb BAC Contig in the Proximal Portion of the Mouse X Chromosome and Regional Mapping of the scurfy Mutation by Means, Gary D., Toy, Dean Y., Baum, Peter R., Derry, Jonathan M.J.

“…A physical clone contig has been constructed, spanning 2 Mb on the proximal mouse X chromosome containing the mouse scurfy (sf) and tattered (Td) mutations…”
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CD33 SNP Genotype and Splice Variation Are Associated with CD33 Cell Surface Expression and SGN-CD33A Pharmacokinetics by Tarlock, Katherine, Wang, Zixing, Rohm, Rory, Biechele, Travis, Ries, Rhonda E., Hylkema, Tiffany, Lamba, Jatinder K, Means, Gary D, Thurman, Robert, Arthur, Bill, Meshinchi, Soheil

“…The cell surface antigen CD33 is expressed on the majority of AML blasts and is appropriate for immunotherapeutic targeting with antibody drug conjugates…”
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Transgenic rescue of the tattered phenotype by using a BAC encoding Ebp by Means, G D, Boyd, Y, Willis, C R, Derry, J M

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Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis by Simpson, E R, Mahendroo, M S, Means, G D, Kilgore, M W, Hinshelwood, M M, Graham-Lorence, S, Amarneh, B, Ito, Y, Fisher, C R, Michael, M D

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Glucagon auto-immunization fails to stimulate food intake or growth in young rabbits by Means, G D, Burns, J M

“…1. To further investigate the possible role of glucagon in appetite control, weaned rabbits were auto-immunized using a glucagon-bovine serum albumin conjugate…”
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Tissue-specific expression of human P-450AROM. The promoter responsible for expression in adipose tissue is different from that utilized in placenta by MAHENDROO, M. S, MEANS, G. D, MENDELSON, C. R, SIMPSON, E. R

“…The biosynthesis of estrogens from androgens is catalyzed by a enzyme of the endoplasmic reticulum termed aromatase cytochrome P-450 (P-450AROM). The gene…”
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Tissue-specific promoters regulate aromatase cytochrome P450 expression by Simpson, E R, Mahendroo, M S, Means, G D, Kilgore, M W, Corbin, C J, Mendelson, C R

“…In the human, estrogen biosynthesis occurs in several tissue sites, including ovary, placenta, adipose, and brain. Recent work from our laboratory has…”
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Mutations in a Δ 8 -Δ 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata by Derry, Jonathan M.J, Gormally, Emmanuelle, Means, Gary D, Zhao, Wei, Meindl, Alfons, Kelley, Richard I, Boyd, Yvonne, Herman, Gail E

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Mutations in a Δ8-Δ7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata by DERRY, J. M. J, GORMALLY, E, MEANS, G. D, WEI ZHAO, MEINDL, A, KELLEY, R. I, BOYD, Y, HERMAN, G. E

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Alternative promotion of aromatase P-450 expression in the human placenta by Kilgore, M W, Means, G D, Mendelson, C R, Simpson, E R

“…We have previously reported the isolation and characterization of the human gene encoding aromatase cytochrome P-450 (P-450AROM). The gene had been…”
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Tissue-specific promoters regulate aromatase cytochrome P450 expression by Simpson, E R, Mahendroo, M S, Means, G D, Kilgore, M W, Corbin, C J, Mendelson, C R

“…In humans, estrogen biosynthesis occurs in several tissue sites, including ovary, placenta, adipose, and brain. Recent work from our laboratory indicates that…”
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Use of Molecular Probes to Study Regulation of Aromatase Cytochrome P-4501 by Mendelson, Carole R., Means, Gary D., Mahendroo, Mala S., JO Corbin, C., Steinkampf, Michael P., Graham-Lorence, Sandra, Simpson, Evan R.

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