Search Results - "Means, A."

Modern Strategies To Achieve Tissue-Mimetic, Mechanically Robust Hydrogels by Means, A. Kristen, Grunlan, Melissa A

“…Hydrogels are frequently used biomaterials due to their similarity in hydration and structure to biological tissues. However, their utility is limited by poor…”
Get full text

Perfusion and endothelialization of engineered tissues with patterned vascular networks by Kinstlinger, Ian S., Calderon, Gisele A., Royse, Madison K., Means, A. Kristen, Grigoryan, Bagrat, Miller, Jordan S.

“…As engineered tissues progress toward therapeutically relevant length scales and cell densities, it is critical to deliver oxygen and nutrients throughout the…”
Get full text

Steady-state approximations for Hodgkin-Huxley cell models: Reduction of order for uterine smooth muscle cell model by Means, Shawn A, Roesler, Mathias W, Garrett, Amy S, Cheng, Leo, Clark, Alys R

“…Multi-scale mathematical bioelectrical models of organs such as the uterus, stomach or heart present challenges both for accuracy and computational…”
Get full text

Double Network Hydrogels that Mimic the Modulus, Strength, and Lubricity of Cartilage by Means, A. Kristen, Shrode, Courtney S, Whitney, Lauren V, Ehrhardt, Daniel A, Grunlan, Melissa A

“…The development of a hydrogel-based synthetic cartilage has the potential to overcome many limitations of current chondral defect treatments. Many attempts…”
Get full text

A permutation method for network assembly by Means, Shawn A, Bläsche, Christian, Laing, Carlo R

“…We present a method for assembling directed networks given a prescribed bi-degree (in- and out-degree) sequence. This method utilises permutations of initial…”
Get full text

A multi-scale spatial model of hepatitis-B viral dynamics by Cangelosi, Quentin, Means, Shawn A, Ho, Harvey

“…Chronic hepatitis B viral infection (HBV) afflicts around 250 million individuals globally and few options for treatment exist. Once infected, the virus…”
Get full text

A spatial-temporal model for zonal hepatotoxicity of acetaminophen by Means, Shawn A., Ho, Harvey

“…The metabolism zonation in liver lobules is well known yet its incorporation into the mathematical models of acetaminophen (APAP) metabolism is still primitive…”
Get full text

Multichannel mapping of in vivo rat uterine myometrium exhibits both high and low frequency electrical activity in non-pregnancy by Garrett, Amy S., Roesler, Mathias W., Athavale, Omkar N., Du, Peng, Means, Shawn A., Clark, Alys R., Cheng, Leo K.

“…The uterus exhibits intermittent electrophysiological activity in vivo. Although most active during labor, the non-pregnant uterus can exhibit activity of…”
Get full text

Thermoresponsive Double Network Hydrogels with Exceptional Compressive Mechanical Properties by Means, A. Kristen, Ehrhardt, Daniel A., Whitney, Lauren V., Grunlan, Melissa A.

“…The utility of thermoresponsive hydrogels, such as those based on poly(N‐isopropylacrylamide) (PNIPAAm), is severely limited by their deficient mechanical…”
Get full text

Modeling and experimental approaches for elucidating multi-scale uterine smooth muscle electro- and mechano-physiology: A review by Garrett, Amy S, Means, Shawn A, Roesler, Mathias W, Miller, Kiara J W, Cheng, Leo K, Clark, Alys R

“…The uterus provides protection and nourishment (via its blood supply) to a developing fetus, and contracts to deliver the baby at an appropriate time, thereby…”
Get full text

Calmodulin-Dependent Kinase II Mediates Vascular Smooth Muscle Cell Proliferation and Is Potentiated by Extracellular Signal Regulated Kinase by Cipolletta, E, Monaco, S, Maione, A. S, Vitiello, L, Campiglia, P, Pastore, L, Franchini, C, Novellino, E, Limongelli, V, Bayer, K. U, Means, A. R, Rossi, G, Trimarco, B, Iaccarino, G, Illario, M

“…Vascular smooth muscle cell (VSMC) proliferation contributes to vascular remodeling in atherosclerosis and hypertension. Calcium-dependent signaling through…”
Get full text

A self-cleaning, mechanically robust membrane for minimizing the foreign body reaction: towards extending the lifetime of sub-Q glucose biosensors by Means, A. Kristen, Dong, Ping, Clubb, Fred J., Friedemann, Molly C., Colvin, Lydia E., Shrode, Courtney A., Coté, Gerard L., Grunlan, Melissa A.

“…Long-term, subcutaneously implanted continuous glucose biosensors have the potential to improve diabetes management and reduce associated complications…”
Get full text

Ca(2+)/CaM-dependent kinases: from activation to function by Hook, S S, Means, A R

“…Calmodulin (CaM) is an essential protein that serves as a ubiquitous intracellular receptor for Ca(2+). The Ca(2+)/CaM complex initiates a plethora of…”
Get full text

Self-Cleaning, Thermoresponsive P(NIPAAm-co-AMPS) Double Network Membranes for Implanted Glucose Biosensors by Fei, Ruochong, Means, A. Kristen, Abraham, Alexander A., Locke, Andrea K., Coté, Gerard L., Grunlan, Melissa A.

“…A self‐cleaning membrane that periodically rids itself of attached cells to maintain glucose diffusion could extend the lifetime of implanted glucose…”
Get full text

Foreign Body Reaction to a Subcutaneously Implanted Self-Cleaning, Thermoresponsive Hydrogel Membrane for Glucose Biosensors by Abraham, Alexander A, Means, A. Kristen, Clubb, Fred J, Fei, Ruochong, Locke, Andrea K, Gacasan, Erica G, Coté, Gerard L, Grunlan, Melissa A

“…Toward achieveing a subcutaneously implanted glucose biosensor with long-term functionality, a thermoresponsive membrane previously shown to have potential to…”
Get full text

Identification of Markers of Taxane Sensitivity Using Proteomic and Genomic Analyses of Breast Tumors from Patients Receiving Neoadjuvant Paclitaxel and Radiation by Bauer, Joshua A, Chakravarthy, A Bapsi, Rosenbluth, Jennifer M, Mi, Deming, Seeley, Erin H, De Matos Granja-Ingram, Nara, Olivares, Maria G, Kelley, Mark C, Mayer, Ingrid A, Meszoely, Ingrid M, Means-Powell, Julie A, Johnson, Kimberly N, Tsai, Chiaojung Jillian, Ayers, Gregory D, Sanders, Melinda E, Schneider, Robert J, Formenti, Silvia C, Caprioli, Richard M, Pietenpol, Jennifer A

“…Purpose: To identify molecular markers of pathologic response to neoadjuvant paclitaxel/radiation treatment, protein and gene expression profiling were done on…”
Get full text

Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia by Ray, K C, Moss, M E, Franklin, J L, Weaver, C J, Higginbotham, J, Song, Y, Revetta, F L, Blaine, S A, Bridges, L R, Guess, K E, Coffey, R J, Crawford, H C, Washington, M K, Means, A L

“…Pancreatic cancer remains as one of the most deadly cancers with few treatment options at late stages and little information about how it develops through…”
Get full text

Illuminating HBV with multi-scale modeling by Means, Shawn A., Ali, Md A., Ho, Harvey

“…Unfortunately for the estimated 250 million sufferers of chronic hepatitis-B viral (HBV) infection worldwide, the liver terrain is typically ignored. An…”
Get full text

Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4 by Means, Anthony R, Wu, Joy Y, Ribar, Thomas J, Cummings, David E, Burton, Kimberly A, McKnight, G. Stanley

“…Ca2+/calmodulin-dependent protein kinase IV (Camk4; also known as CaMKIV), a multifunctional serine/threonine protein kinase with limited tissue distribution,…”
Get full text

Characterization of a 1,4-disubstituted 1,2,3-triazole binding to T box antiterminator RNA by Zhou, S., Means, J.A., Acquaah-Harrison, G., Bergmeier, S.C., Hines, J.V.

“…The T box riboswitch regulates the transcription of many bacterial genes by structurally responding to cognate non-aminoacylated (uncharged) tRNA. The…”
Get full text