Search Results - "Meaney, D. F"

Diagnosis of traumatic brain injury using miRNA signatures in nanomagnetically isolated brain-derived extracellular vesicles by Ko, J, Hemphill, M, Yang, Z, Sewell, E, Na, Y J, Sandsmark, D K, Haber, M, Fisher, S A, Torre, E A, Svane, K C, Omelchenko, A, Firestein, B L, Diaz-Arrastia, R, Kim, J, Meaney, D F, Issadore, D

“…The accurate diagnosis and clinical management of traumatic brain injury (TBI) is currently limited by the lack of accessible molecular biomarkers that reflect…”
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Tissue-level thresholds for axonal damage in an experimental model of central nervous system white matter injury by Bain, A C, Meaney, D F

“…In vivo, tissue-level, mechanical thresholds for axonal injury were determined by comparing morphological injury and electrophysiological impairment to…”
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Immediate coma following inertial brain injury dependent on axonal damage in the brainstem by SMITH, D. H, NONAKA, M, MILLER, R, LEONI, M, CHEN, X.-H, ALSOP, D, MEANEY, D. F

“…Immediate and prolonged coma following brain trauma has been shown to result from diffuse axonal injury (DAI). However, the relationship between the…”
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Traumatic injury induces differential expression of cell death genes in organotypic brain slice cultures determined by complementary DNA array hybridization by Morrison, B., Eberwine, J.H., Meaney, D.F., McIntosh, T.K.

“…The expression of a large panel of selected genes hypothesized to play a central role in post-traumatic cell death was shown to be differentially altered in…”
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Accumulation of Amyloid β and Tau and the Formation of Neurofilament Inclusions Following Diffuse Brain Injury in the Pig by SMITH, D H, CHEN, X H, NONAKA, M, TROJANOWSKI, J Q, LEE, VM-Y, SAATMAN, K E, LEONI, M J, XU, B-N, WOLF, J A, MEANEY, D F

“…Brain trauma in humans increases the risk for developing Alzheimer disease (AD) and may induce the acute formation of AD-like plaques containing amyloid p…”
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In vitro central nervous system models of mechanically induced trauma: a review by Morrison, 3rd, B, Saatman, K E, Meaney, D F, McIntosh, T K

“…Injury is one of the leading causes of death among all people below the age of 45 years. In the United States, traumatic brain injury (TBI) and spinal cord…”
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Neuropathological sequelae of traumatic brain injury: relationship to neurochemical and biomechanical mechanisms by McIntosh, T K, Smith, D H, Meaney, D F, Kotapka, M J, Gennarelli, T A, Graham, D I

“…Brain injury is the leading cause of death among individuals under the age of 45 years in the United States and Europe. Recently, the neuropathologic…”
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Matrices with Compliance Comparable to that of Brain Tissue Select Neuronal over Glial Growth in Mixed Cortical Cultures by Georges, Penelope C., Miller, William J., Meaney, David F., Sawyer, Evelyn S., Janmey, Paul A.

“…Cortical neurons and astrocytes respond strongly to changes in matrix rigidity when cultured on flexible substrates. In this study, existing polyacrylamide gel…”
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A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects by Smith, D H, Soares, H D, Pierce, J S, Perlman, K G, Saatman, K E, Meaney, D F, Dixon, C E, McIntosh, T K

“…Controlled cortical impact (CCI), using a pneumatically driven impactor to produce traumatic brain injury, has been characterized previously in both the ferret…”
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Characterization of Diffuse Axonal Pathology and Selective Hippocampal Damage following Inertial Brain Trauma in the Pig by Smith, Douglas H, Chen, Xiao-han, Xu, Bai-Nan, McIntosh, Tracy K, Gennarelli, Thomas A, Meaney, David F

“…Dynamic deformation applied to white matter tracts is a common feature of human brain trauma, and may result in diffuse axonal injury (DAI). To produce DAI in…”
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Relationship between structural modeling and hyperelastic material behavior: application to CNS white matter by Meaney, D F

“…Recent measurements of the material properties of brain tissue allow an examination of the underlying microstructural basis in both physiological and…”
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Biomechanical analysis of experimental diffuse axonal injury by Meaney, D F, Smith, D H, Shreiber, D I, Bain, A C, Miller, R T, Ross, D T, Gennarelli, T A

“…The purpose of this paper is to present results from methodologies used in our laboratory that are targeted toward identifying specific brain injury…”
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Evolution of Neurofilament Subtype Accumulation in Axons Following Diffuse Brain Injury in the Pig by Chen, Xiao-Han, Meaney, David F, XU, Bai-Nan, Nonaka, Masahiro, Mcintosh, Tracy K, Wolf, John A, Saatman, Kathryn E, Smith, Douglas H

“…Although accumulation of neurofilament (NF) proteins in axons has been recognized as a prominent feature of brain trauma, the temporal course of the…”
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Dynamic mechanical stretch of organotypic brain slice cultures induces differential genomic expression: relationship to mechanical parameters by Morrison, 3rd, B, Meaney, D F, Margulies, S S, McIntosh, T K

“…Although the material properties of biological tissues are reasonably well established, recent studies have suggested that the biological response of brain…”
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High‐Field Proton Magnetic Resonance Spectroscopy of a Swine Model for Axonal Injury by Cecil, Kim M., Lenkinski, Robert E., Meaney, David F., McIntosh, Tracy K., Smith, Douglas H.

“…: A miniature swine model for diffuse brain injury has recently been developed that replicates the inertial loading conditions associated with rotational…”
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Diffuse axonal injury by Meaney, D F, Margulies, S S, Smith, D H

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TUNEL-positive staining of surface contusions after fatal head injury in man by SMITH, F. M, RAGHUPATHI, R, MACKINNON, M.-A, MCINTOSH, T. K, SAATMAN, K. E, MEANEY, D. F, GRAHAM, D. I

“…In frontal lobe contusions obtained post mortem from 18 patients who survived between 6 h and 10 days after head injury, DNA fragmentation associated with…”
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Mechanical characterization of an in vitro device designed to quantitatively injure living brain tissue by MORRISON, B. III, MEANEY, D. F, MCINTOSH, T. K

“…Due to the nonlinear, viscoelastic material properties of brain, its mechanical response is dependent upon its total strain history. Therefore, a low strain…”
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Magnetic resonance spectroscopy of diffuse brain trauma in the pig by Smith, D H, Cecil, K M, Meaney, D F, Chen, X H, McIntosh, T K, Gennarelli, T A, Lenkinski, R E

“…The acute metabolic events linked to the evolution of selective axonal pathology in the white matter following diffuse brain injury have not previously been…”
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Experimental Investigation of Cerebral Contusion: Histopathological and Immunohistochemical Evaluation of Dynamic Cortical Deformation by Shreiber, David I, Bain, Allison C, Ross, Douglas T, Smith, Douglas H, Gennarelli, T A, McIntosh, Tracy K, Meaney, David F

“…We used a new approach, termed dynamic cortical deformation (DCD), to study the neuronal, vascular, and glial responses that occur in focal cerebral…”
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