Search Results - "Meana, J. Javier"

Chronic Pain Leads to Concomitant Noradrenergic Impairment and Mood Disorders by Alba-Delgado, Cristina, Llorca-Torralba, Meritxell, Horrillo, Igor, Ortega, Jorge E, Mico, Juan Antonio, Sánchez-Blázquez, Pilar, Meana, J. Javier, Berrocoso, Esther

“…Background Patients suffering chronic pain are at high risk of suffering long-lasting emotional disturbances characterized by persistent low mood and anxiety…”
Get full text

Chronic cannabis promotes pro-hallucinogenic signaling of 5-HT2A receptors through Akt/mTOR pathway by Ibarra-Lecue, Inés, Mollinedo-Gajate, Irene, Meana, J Javier, Callado, Luis F, Diez-Alarcia, Rebeca, Urigüen, Leyre

“…Long-term use of potent cannabis during adolescence increases the risk of developing schizophrenia later in life, but to date, the mechanisms involved remain…”
Get full text

Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants by Martín-Hernández, David, Caso, Javier R, Javier Meana, J, Callado, Luis F, Madrigal, José L M, García-Bueno, Borja, Leza, Juan C

“…Studies show that Toll-like receptors (TLRs), members of the innate immune system, might participate in the pathogenesis of the major depressive disorder…”
Get full text

Quantification of endocannabinoids in postmortem brain of schizophrenic subjects by Muguruza, Carolina, Lehtonen, Marko, Aaltonen, Niina, Morentin, Benito, Meana, J. Javier, Callado, Luis F

“…Abstract Numerous studies have implicated the endocannabinoid system in the pathophysiology of schizophrenia. Endocannabinoids have been measured in blood and…”
Get full text

Group II Metabotropic Glutamate Receptors as Targets for Novel Antipsychotic Drugs by Muguruza, Carolina, Meana, J Javier, Callado, Luis F

“…Schizophrenia is a chronic psychiatric disorder which substantially impairs patients' quality of life. Despite the extensive research in this field, the…”
Get full text

Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes by Zhang, Qiang, Ma, Sai, Liu, Zhengzhi, Zhu, Bohan, Zhou, Zirui, Li, Gaoshan, Meana, J. Javier, González-Maeso, Javier, Lu, Chang

“…The genome-wide DNA methylation profile, or DNA methylome, is a critical component of the overall epigenomic landscape that modulates gene activities and cell…”
Get full text

Recent cocaine use is a significant risk factor for sudden cardiovascular death in 15-49-year-old subjects: a forensic case-control study by Morentin, Benito, Ballesteros, Javier, Callado, Luis F., Meana, J. Javier

“…Aims The aims of the present study were to: (i) evaluate the prevalence of recent cocaine use in adolescents and young adults who had died by sudden…”
Get full text

Endocannabinoid system imbalance in the postmortem prefrontal cortex of subjects with schizophrenia by Muguruza, Carolina, Morentin, Benito, Meana, J Javier, Alexander, Stephen PH, Callado, Luis F

“…Background: The endocannabinoid system – comprising cannabinoid receptors, endocannabinoid ligands and their synthesis and inactivation enzymes – has been…”
Get full text

Identification of a serotonin/glutamate receptor complex implicated in psychosis by Chan, Pokman, Ang, Rosalind L, Weisstaub, Noelia V, Callado, Luis F, Sealfon, Stuart C, Okawa, Yuuya, Meana, J. Javier, Gingrich, Jay A, López-Giménez, Juan F, Zhou, Mingming, Milligan, Graeme, Yuen, Tony, Filizola, Marta, González-Maeso, Javier

“…The psychosis associated with schizophrenia is characterized by alterations in sensory processing and perception. Some antipsychotic drugs were identified by…”
Get full text

Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function by Moreno, José L., Muguruza, Carolina, Umali, Adrienne, Mortillo, Steven, Holloway, Terrell, Pilar-Cuéllar, Fuencisla, Mocci, Giuseppe, Seto, Jeremy, Callado, Luis F., Neve, Rachael L., Milligan, Graeme, Sealfon, Stuart C., López-Giménez, Juan F., Meana, J. Javier, Benson, Deanna L., González-Maeso, Javier

“…Serotonin and glutamate G protein-coupled receptor (GPCR) neurotransmission affects cognition and perception in humans and rodents. GPCRs are capable of…”
Get full text

Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia by García-Bueno, Borja, PhD, MacDowell, Karina S., PhD, Leza, Juan C., PhD, MD, Callado, Luis F., PhD, MD, Meana, J. Javier, PhD, MD, Mas, Sergi, PhD, Lafuente, Amalia, PhD, Bernardo, Miguel, PhD, MD, Gassó, Patricia, PhD

“…Background Alterations in the innate immune/inflammatory system may underlie the pathophysiology of schizophrenia, but we do not understand the mechanisms…”
Get full text

Long lasting effects of early-life stress on glutamatergic/GABAergic circuitry in the rat hippocampus by Martisova, Eva, Solas, Maite, Horrillo, Igor, Ortega, Jorge E., Meana, J. Javier, Tordera, Rosa María, Ramírez, María Javier

“…The objective of the present work was to study the effects of an early-life stress (maternal separation, MS) in the excitatory/inhibitory ratio as a potential…”
Get full text

Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia by Zhu, Bohan, Ainsworth, Richard I, Wang, Zengmiao, Liu, Zhengzhi, Sierra, Salvador, Deng, Chengyu, Callado, Luis F, Meana, J Javier, Wang, Wei, Lu, Chang, González-Maeso, Javier

“…Genome-wide association studies have revealed >270 loci associated with schizophrenia risk, yet these genetic factors do not seem to be sufficient to fully…”
Get full text

High number of mitochondrial DNA alterations in postmortem brain tissue of patients with schizophrenia compared to healthy controls by Bulduk, Bengisu K., Tortajada, Juan, Valiente-Pallejà, Alba, Callado, Luís F., Torrell, Helena, Vilella, Elisabet, Meana, J․ Javier, Muntané, Gerard, Martorell, Lourdes

“…•MtDNA deletions and point mutations are common in schizophrenia patients.•Ultra-deep sequencing uncovers mtDNA alterations in schizophrenia brain…”
Get full text

Differential brain ADRA2A and ADRA2C gene expression and epigenetic regulation in schizophrenia. Effect of antipsychotic drug treatment by Brocos-Mosquera, Iria, Miranda-Azpiazu, Patricia, Muguruza, Carolina, Corzo-Monje, Virginia, Morentin, Benito, Meana, J. Javier, Callado, Luis F., Rivero, Guadalupe

“…Postsynaptic α 2A -adrenoceptor density is enhanced in the dorsolateral prefrontal cortex (DLPFC) of antipsychotic-treated schizophrenia subjects. This…”
Get full text

Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia by Moreno, José L, Miranda-Azpiazu, Patricia, García-Bea, Aintzane, Younkin, Jason, Cui, Meng, Kozlenkov, Alexey, Ben-Ezra, Ariel, Voloudakis, Georgios, Fakira, Amanda K, Baki, Lia, Ge, Yongchao, Georgakopoulos, Anastasios, Morón, José A, Milligan, Graeme, López-Giménez, Juan F, Robakis, Nikolaos K, Logothetis, Diomedes E, Meana, J Javier, González-Maeso, Javier

“…Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) can form multiprotein complexes (heteromers), which can alter the…”
Get more information

Chronic fluoxetine reverses the effects of chronic corticosterone treatment on α2-adrenoceptors in the rat frontal cortex but not locus coeruleus by Horrillo, Igor, Ortega, Jorge E., Diez-Alarcia, Rebeca, Urigüen, Leyre, Meana, J. Javier

“…Disruption of the hypothalamic-pituitary-adrenal axis is an established finding in patients with anxiety and/or depression. Chronic corticosterone…”
Get full text

HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity by Kurita, Mitsumasa, Holloway, Terrell, García-Bea, Aintzane, Kozlenkov, Alexey, Friedman, Allyson K, Moreno, José L, Heshmati, Mitra, Golden, Sam A, Kennedy, Pamela J, Takahashi, Nagahide, Dietz, David M, Mocci, Giuseppe, Gabilondo, Ane M, Hanks, James, Umali, Adrienne, Callado, Luis F, Gallitano, Amelia L, Neve, Rachael L, Shen, Li, Buxbaum, Joseph D, Han, Ming-Hu, Nestler, Eric J, Meana, J Javier, Russo, Scott J, González-Maeso, Javier

“…The authors show that chronic treatment with antipsychotic drugs decreases expression of mGlu2 and histone acetylation at its promoter in frontal cortex. This…”
Get full text

Schizophrenia and depression, two poles of endocannabinoid system deregulation by Rodríguez-Muñoz, María, Sánchez-Blázquez, Pilar, Callado, Luis F., Meana, J. Javier, Garzón-Niño, Javier

“…The activity of certain G protein-coupled receptors (GPCRs) and of glutamate N -Methyl-D-aspartate receptors (NMDARs) is altered in both schizophrenia and…”
Get full text

G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits by Kossatz, Elk, Diez-Alarcia, Rebeca, Gaitonde, Supriya A., Ramon-Duaso, Carla, Stepniewski, Tomasz Maciej, Aranda-Garcia, David, Muneta-Arrate, Itziar, Tepaz, Elodie, Saen-Oon, Suwipa, Soliva, Robert, Shahraki, Aida, Moreira, David, Brea, Jose, Loza, Maria Isabel, de la Torre, Rafael, Kolb, Peter, Bouvier, Michel, Meana, J. Javier, Robledo, Patricia, Selent, Jana

“…G protein-coupled receptors (GPCRs) are sophisticated signaling machines able to simultaneously elicit multiple intracellular signaling pathways upon…”
Get full text