Search Results - "Mealey, K.L."

Effect of the Canine ABCB1‐1Δ Mutation on Sedation after Intravenous Administration of Acepromazine by Deshpande, D., Hill, K.E., Mealey, K.L., Chambers, J.P., Gieseg, M.A.

“…BACKGROUND: Dog breeds with the ABCB1‐1Δ mutation have substantially truncated nonfunctional P‐glycoprotein. Dogs homozygous for this mutation (mut/mut) are…”
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Identification of DNA variants in the canine beta-1 adrenergic receptor gene by Maran, B.A., Mealey, K.L., Lahmers, S.M., Nelson, O.L., Meurs, K.M.

“…Beta-adrenergic receptor antagonists are utilized for the management of several cardiac diseases in the dog. In humans the beneficial effects of…”
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P‐Glycoprotein Mediated Drug Interactions in Animals and Humans with Cancer by Mealey, K.L., Fidel, J.

“…Drug–drug interactions can cause unanticipated patient morbidity and mortality. The consequences of drug–drug interactions can be especially severe when…”
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Systemic absorption of amitriptyline and buspirone after oral and transdermal administration to healthy cats by Mealey, K.L, Peck, K.E, Bennett, B.S, Sellon, R.K, Swinney, G.R, Melzer, K, Gokhale, S.A, Krone, T.M

“…A prospective study was performed to determine the relative availability of buspirone and amitriptyline after oral and transdermal routes of administration in…”
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Pharmacokinetics and cardiopulmonary effects of guaifenesin in donkeys by Matthews, N.S, Peck, K.E, Mealey, K.L, Taylor, T.S, Ray, A.C

“…Five donkeys and three horses were given guaifenesin, intravenously, by gravity administration, until recumbency was produced. The time and dose required to…”
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Therapeutic implications of the MDR-1 gene by Mealey, K.L

“…Drug transporters significantly influence drug pharmacokinetics and pharmacodynamics. P-glycoprotein (P-gp), the product of the MDR1 (ABCB1) gene, is among the…”
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Association between ABCB 1 Genotype and Seizure Outcome in Collies with Epilepsy by Muñana, K.R., Nettifee‐Osborne, J.A., Bergman, R.L., Mealey, K.L.

“…Background Medically refractory seizures are an important problem in both humans and dogs with epilepsy. Altered expression of ABCB 1, the gene encoding for…”
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Normal Dogs Treated with Famotidine for 14 days Have Only Transient Increases in Serum Gastrin Concentrations by Mordecai, A., Sellon, R.K., Mealey, K.L.

“…Background In people, serum gastrin concentrations increase in response to administration of H2 receptor antagonists, but the effect of famotidine…”
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Association between ABCB1 Genotype and Seizure Outcome in Collies with Epilepsy by Muñana, K.R., Nettifee‐Osborne, J.A., Bergman, R.L., Mealey, K.L.

“…Background Medically refractory seizures are an important problem in both humans and dogs with epilepsy. Altered expression of ABCB1, the gene encoding for…”
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ABCB1-1Δ Polymorphism Can Predict Hematologic Toxicity in Dogs Treated with Vincristine by Mealey, K.L., Fidel, J., Gay, J.M., Impellizeri, J.A., Clifford, C.A., Bergman, P.J.

“…Background: Dogs that harbor the naturally occurring ABCB1‐1Δ polymorphism experience increased susceptibility to avermectin‐induced neurological toxicosis as…”
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Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and ABCB1 wild type dogs by MEALEY, K.L, WAITING, D, RAUNIG, D.L, SCHMIDT, K.R, NELSON, F.R

“…Mealey, K.L., Waiting, D., Raunig, D.L., Schmidt, K.R., Nelson, F.R. Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and…”
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Variation in Theileria equi drug susceptibility in vitro and the potential role of ABC transporters as mediators of parasitic drug resistance by Hines, S.A., Kappmeyer, L.S., Mealey, K.L., Leib, S.R., Johnson, W.C., Ueti, M.W., Knowles, D.P., Mealey, R.H.

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Frequency of the mutant MDR1 allele associated with multidrug sensitivity in a sample of herding breed dogs living in Australia by Mealey, Katrina L., Munyard, Kylie A., Bentjen, Steven A.

“…A study was performed to determine the frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample of Collies and other herding…”
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Assessment of antiepileptic drugs as substrates for canine P-glycoprotein by West, C.L, Mealey, K.L

“…To determine whether antiepileptic drugs (AEDs) are substrates for canine P-glycoprotein (P-gp). Sample Population-OS2.4/Doxo cells (canine osteosarcoma cells…”
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effects of inhibiting cytochrome P450 3A, p-glycoprotein, and gastric acid secretion on the oral bioavailability of methadone in dogs by Kukanich, B, Lascelles, B.D.X, Aman, A.M, Mealey, K.L, Papich, M.G

“…Methadone is an opioid, which has a high oral bioavailability (>70%) and a long elimination half-life (>20 h) in human beings. The purpose of this study was to…”
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Frequency of the mutant MDR1 allele associated with multidrug sensitivity in a sample of collies from France by Hugnet, C, Bentjen, S.A, Mealey, K.L

“…A study was performed to determine the frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample of collies living in France…”
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Effect of low doses of cosyntropin on serum cortisol concentrations in clinically normal dogs by Martin, L.G, Behrend, E.N, Mealey, K.L, Carpenter, D.M, Hickey, K.C

“…To determine the lowest of 5 doses of cosyntropin (1.0, 0.5, 0.1, 0.05, or 0.01 microg/kg) administered IV that stimulates maximal cortisol secretion in…”
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Comparative pharmacokinetics of meloxicam in clinically normal horses and donkeys by Sinclair, M.D, Mealey, K.L, Matthews, N.S, Peck, K.E, Taylor, T.S, Bennett, B.S

“…Objective-To determine the disposition of a bolus of meloxicam (administered IV) in horses and donkeys (Equus asinus) and compare the relative pharmacokinetic…”
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Survival time, lifespan, and quality of life in dogs with idiopathic Fanconi syndrome by Yearley, J.H, Hancock, D.D, Mealey, K.L

“…To evaluate survival time of dogs with idiopathic Fanconi syndrome. Case series. 60 dogs with idiopathic Fanconi syndrome. Data were collected by means of…”
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ABCB1-1delta Polymorphism Can Predict Hematologic Toxicity in Dogs Treated with Vincristine by Mealey, K.L, Fidel, J, Gay, J.M, Impellizeri, J.A, Clifford, C.A, Bergman, P.J

“…Dogs that harbor the naturally occurring ABCB1-1Delta polymorphism experience increased susceptibility to avermectin-induced neurological toxicosis as a result…”
Get full text