Search Results - "Meakin, J"

Tired, sweaty team member by Meakin, J.

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Effects of sex, age, body height and body weight on spinal loads: Sensitivity analyses in a subject-specific trunk musculoskeletal model by Ghezelbash, F, Shirazi-Adl, A, Arjmand, N, El-Ouaaid, Z, Plamondon, A, Meakin, J.R

“…Abstract Subject-specific parameters influence spinal loads and the risk of back disorders but their relative effects are not well understood. The objective of…”
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Phase II study of single-agent panitumumab in patients with incurable cutaneous squamous cell carcinoma by Foote, M.C., McGrath, M., Guminski, A., Hughes, B.G.M., Meakin, J., Thomson, D., Zarate, D., Simpson, F., Porceddu, S.V.

“…Although advanced cutaneous squamous cell carcinoma (CSCC) is quite common, there are few prospective trials regarding its optimal management. This study…”
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A novel in-vitro model of intervertebral disc degeneration using hyperphysiological loading by Rivera Tapia, E.D., Meakin, J.R., Holsgrove, T.P.

“…Intervertebral disc (IVD) degeneration includes changes in tissue biomechanics, physical attributes, biochemical composition, disc microstructure, and…”
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In-vitro models of disc degeneration – A review of methods and clinical relevance by Rivera Tapia, E.D., Meakin, J.R., Holsgrove, T.P.

“…The intervertebral disc (IVD) provides flexibility, acts as a shock absorber, and transmits load. Degeneration of the IVD includes alterations in the…”
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The beta secretase BACE1 regulates the expression of insulin receptor in the liver by Meakin, Paul J., Mezzapesa, Anna, Benabou, Eva, Haas, Mary E., Bonardo, Bernadette, Grino, Michel, Brunel, Jean-Michel, Desbois-Mouthon, Christèle, Biddinger, Sudha B., Govers, Roland, Ashford, Michael L. J., Peiretti, Franck

“…Insulin receptor (IR) plays a key role in the control of glucose homeostasis; however, the regulation of its cellular expression remains poorly understood…”
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Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation by McGuire, Victoria A., Ruiz-Zorrilla Diez, Tamara, Emmerich, Christoph H., Strickson, Sam, Ritorto, Maria Stella, Sutavani, Ruhcha V., Weiβ, Anne, Houslay, Kirsty F., Knebel, Axel, Meakin, Paul J., Phair, Iain R., Ashford, Michael L. J., Trost, Matthias, Arthur, J. Simon C.

“…Dimethyl fumarate (DMF) possesses anti-inflammatory properties and is approved for the treatment of psoriasis and multiple sclerosis. While clinically…”
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Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis by Chowdhry, Sudhir, Nazmy, Maiiada H., Meakin, Paul J., Dinkova-Kostova, Albena T., Walsh, Shaun V., Tsujita, Tadayuki, Dillon, John F., Ashford, Michael L.J., Hayes, John D.

“…Nonalcoholic steatohepatitis (NASH) arises from nonalcoholic fatty liver disease (NAFLD) as a consequence of oxidative stress. Herein we report that the…”
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The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis by Deldicque, Louise, Cani, Patrice D, Philp, Andrew, Raymackers, Jean-Marc, Meakin, Paul J, Ashford, Michael L J, Delzenne, Nathalie M, Francaux, Marc, Baar, Keith

“…High-fat diets are known to decrease muscle protein synthesis, the adaptation to overload, and insulin sensitivity. Conditions that disrupt endoplasmic…”
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DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks by Pinto, Lia M, Pailas, Alexandros, Bondarchenko, Max, Sharma, Abhishek Bharadwaj, Neumann, Katrin, Rizzo, Anthony J, Jeanty, Céline, Nicot, Nathalie, Racca, Carine, Graham, Mindy K, Naughton, Catherine, Liu, Yaqun, Chen, Chun-Long, Meakin, Paul J, Gilbert, Nick, Britton, Sébastien, Meeker, Alan K, Heaphy, Christopher M, Larminat, Florence, Van Dyck, Eric

“…Maintaining chromatin integrity at the repetitive non-coding DNA sequences underlying centromeres is crucial to prevent replicative stress, DNA breaks and…”
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Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice by Meakin, Paul J, Harper, Alex J, Hamilton, D Lee, Gallagher, Jennifer, McNeilly, Alison D, Burgess, Laura A, Vaanholt, Lobke M, Bannon, Kirsten A, Latcham, Judy, Hussain, Ishrut, Speakman, John R, Howlett, David R, Ashford, Michael L J

“…Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease). An…”
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PTPRD and DCC Are Novel BACE1 Substrates Differentially Expressed in Alzheimer's Disease: A Data Mining and Bioinformatics Study by Taylor, Hannah A, Simmons, Katie J, Clavane, Eva M, Trevelyan, Christopher J, Brown, Jane M, Przemyłska, Lena, Watt, Nicole T, Matthews, Laura C, Meakin, Paul J

“…The β-site Amyloid precursor protein Cleaving Enzyme 1 (BACE1) is an extensively studied therapeutic target for Alzheimer's disease (AD), owing to its role in…”
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Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress by Al-Mubarak, Bashayer R., Bell, Karen F.S., Chowdhry, Sudhir, Meakin, Paul J., Baxter, Paul S., McKay, Sean, Dando, Owen, Ashford, Michael L.J., Gazaryan, Irina, Hayes, John D., Hardingham, Giles E.

“…The transcription factor Nrf2 is a stress-responsive master regulator of antioxidant, detoxification and proteostasis genes. In astrocytes, Nrf2-dependent gene…”
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Micro-mechanical damage of needle puncture on bovine annulus fibrosus fibrils studied using polarization-resolved Second Harmonic Generation(P-SHG) microscopy by Wang, J.-Y., Mansfield, J.C., Brasselet, S., Vergari, C., Meakin, J.R., Winlove, C.P.

“…Needle injection has been widely used in spinal therapeutic or diagnostic processes, such as discography. The use of needles has been suspected in causing mild…”
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Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice by Meakin, Paul J., Jalicy, Susan M., Montagut, Gemma, Allsop, David J. P., Cavellini, Daniella L., Irvine, Stuart W., McGinley, Christopher, Liddell, Mary K., McNeilly, Alison D., Parmionova, Karolina, Liu, Yu-Ru, Bailey, Charlotte L. S., Dale, J. Kim, Heisler, Lora K., McCrimmon, Rory J., Ashford, Michael L. J.

“…Obesity places an enormous medical and economic burden on society. The principal driver appears to be central leptin resistance with hyperleptinemia…”
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Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes by Deighton, Ruth F, Márkus, Nóra M, Al-Mubarak, Bashayer, Bell, Karen F S, Papadia, Sofia, Meakin, Paul J, Chowdhry, Sudhir, Hayes, John D, Hardingham, Giles E

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Computer-aided detection in musculoskeletal projection radiography: A systematic review by Gundry, M., Knapp, K., Meertens, R., Meakin, J.R.

“…To investigated the accuracy of computer-aided detection (CAD) software in musculoskeletal projection radiography via a systematic review. Following selection…”
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Sex Differences in the Associations between L-Arginine Pathway Metabolites, Skeletal Muscle Mass and Function, and their Responses to Resistance Exercise, in Old Age by da Boit, M., Tommasi, S., Elliot, D., Zinellu, A., Sotgia, S., Sibson, R., Meakin, J. R., Aspden, R. M., Carru, C., Mangoni, A. A., Gray, Stuart R.

“…Objectives The current study was designed to explore the associations between L-arginine metabolites and muscle mass and function in old age, which are largely…”
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3-D laser confocal microscopy study of the oxidation of NdFeB magnets in atmospheric conditions by Meakin, J.P., Speight, J.D., Sheridan, R.S., Bradshaw, A., Harris, I.R., Williams, A.J., Walton, A.

“…•Room temperature atmospheric oxidation behaviour of sintered NdFeB.•3D laser confocal microscopy measurement of oxide phase growth.•Significant height…”
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Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation by Meakin, Paul J, Morrison, Vicky L, Sneddon, Claire C, Savinko, Terhi, Uotila, Liisa, Jalicy, Susan M, Gabriel, Jennie L, Kang, Li, Ashford, Michael L J, Fagerholm, Susanna C

“…Beta2-integrins are important in leukocyte trafficking and function, and are regulated through the binding of cytoplasmic proteins, such as kindlin-3, to their…”
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