Search Results - "Meagher, Michael"

The cost-effectiveness of gene therapy for severe hemophilia B: a microsimulation study from the United States perspective by Bolous, Nancy S., Chen, Yichen, Wang, Huiqi, Davidoff, Andrew M., Devidas, Meenakshi, Jacobs, Timothy W., Meagher, Michael M., Nathwani, Amit C., Neufeld, Ellis J., Piras, Bryan A., Rodriguez-Galindo, Carlos, Reiss, Ulrike M., Bhakta, Nickhill

“…Adeno-associated virus (AAV)-mediated gene therapy is a novel treatment promising to reduce morbidity associated with hemophilia. Although multiple clinical…”
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Sample Stacking Provides Three Orders of Magnitude Sensitivity Enhancement in SDS Capillary Gel Electrophoresis of Adeno-Associated Virus Capsid Proteins by Zhang, Chao-Xuan, Meagher, Michael M

“…Size-based protein analysis utilizing only 25 ng of total proteins has been realized by sodium dodecyl sulfate capillary gel electrophoresis (SDS CGE) with…”
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Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1 by Mamcarz, Ewelina, Zhou, Sheng, Lockey, Timothy, Abdelsamed, Hossam, Cross, Shane J, Kang, Guolian, Ma, Zhijun, Condori, Jose, Dowdy, Jola, Triplett, Brandon, Li, Chen, Maron, Gabriela, Aldave Becerra, Juan C, Church, Joseph A, Dokmeci, Elif, Love, James T, da Matta Ain, Ana C, van der Watt, Hedi, Tang, Xing, Janssen, William, Ryu, Byoung Y, De Ravin, Suk See, Weiss, Mitchell J, Youngblood, Benjamin, Long-Boyle, Janel R, Gottschalk, Stephen, Meagher, Michael M, Malech, Harry L, Puck, Jennifer M, Cowan, Morton J, Sorrentino, Brian P

“…Eight infants with SCID-X1 had multilineage immune reconstitution after autologous hematopoietic stem-cell transplantation of marrow stem cells transfected…”
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Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency by De Ravin, Suk See, Wu, Xiaolin, Moir, Susan, Anaya-O'Brien, Sandra, Kwatemaa, Nana, Littel, Patricia, Theobald, Narda, Choi, Uimook, Su, Ling, Marquesen, Martha, Hilligoss, Dianne, Lee, Janet, Buckner, Clarissa M, Zarember, Kol A, O'Connor, Geraldine, McVicar, Daniel, Kuhns, Douglas, Throm, Robert E, Zhou, Sheng, Notarangelo, Luigi D, Hanson, I Celine, Cowan, Mort J, Kang, Elizabeth, Hadigan, Coleen, Meagher, Michael, Gray, John T, Sorrentino, Brian P, Malech, Harry L, Kardava, Lela

“…X-linked severe combined immunodeficiency (SCID-X1) is a profound deficiency of T, B, and natural killer (NK) cell immunity caused by mutations inIL2RGencoding…”
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Highly Sensitive SDS Capillary Gel Electrophoresis with Sample Stacking Requiring Only Nanograms of Adeno-Associated Virus Capsid Proteins by Zhang, Chao-Xuan, Meagher, Michael M

“…Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) has been the method of choice in the past decades for size-based protein analysis…”
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Common Trajectories of Highly Effective CD19-Specific CAR T Cells Identified by Endogenous T-cell Receptor Lineages by Wilson, Taylor L, Kim, Hyunjin, Chou, Ching-Heng, Langfitt, Deanna, Mettelman, Robert C, Minervina, Anastasia A, Allen, E Kaitlynn, Métais, Jean-Yves, Pogorelyy, Mikhail V, Riberdy, Janice M, Velasquez, M Paulina, Kottapalli, Pratibha, Trivedi, Sanchit, Olsen, Scott R, Lockey, Timothy, Willis, Catherine, Meagher, Michael M, Triplett, Brandon M, Talleur, Aimee C, Gottschalk, Stephen, Crawford, Jeremy Chase, Thomas, Paul G

“…Current chimeric antigen receptor-modified (CAR) T-cell products are evaluated in bulk, without assessing functional heterogeneity. We therefore generated a…”
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Development of a cGMP-compliant process to manufacture donor-derived, CD45RA-depleted memory CD19-CAR T cells by Kim-Hoehamer, Young-In, Riberdy, Janice M., Zheng, Fei, Park, Jeoungeun J., Shang, Na, Métais, Jean-Yves, Lockey, Timothy, Willis, Catherine, Akel, Salem, Moore, Jennifer, Meagher, Michael M., Velasquez, M. Paulina, Triplett, Brandon M., Talleur, Aimee C., Gottschalk, Stephen, Zhou, Sheng

“…Autologous chimeric antigen receptor (CAR) T cells targeting the CD19 antigen have demonstrated a high complete response rate in relapsed/refractory B-cell…”
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Middle school students' development of an understanding of the concept of function using an applet with no algebraic representations by Meagher, Michael S., Lovett, Jennifer N., McCulloch, Allison W.

“…Middle school students (n = 144) worked with an applet specially designed to introduce the concept of function without using algebraic representations. The…”
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Preferential expansion of CD8+ CD19-CAR T cells postinfusion and the role of disease burden on outcome in pediatric B-ALL by Talleur, Aimee C., Qudeimat, Amr, Métais, Jean-Yves, Langfitt, Deanna, Mamcarz, Ewelina, Crawford, Jeremy Chase, Huang, Sujuan, Cheng, Cheng, Hurley, Caitlin, Madden, Renee, Sharma, Akshay, Suliman, Ali, Srinivasan, Ashok, Velasquez, M. Paulina, Obeng, Esther A., Willis, Catherine, Akel, Salem, Karol, Seth E., Inaba, Hiroto, Bragg, Allison, Zheng, Wenting, Zhou, Sheng M., Schell, Sarah, Tuggle-Brown, MaCal, Cullins, David, Patil, Sagar L, Li, Ying, Thomas, Paul G., Zebley, Caitlin, Youngblood, Benjamin, Pui, Ching-Hon, Lockey, Timothy, Geiger, Terrence L., Meagher, Michael M., Triplett, Brandon M., Gottschalk, Stephen

“…•CD8+ CD19-CAR T cells outcompete their CD4+ counterparts and undergo antigen-driven differentiation after infusion.•Our study highlights the role of disease…”
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Challenging preservice secondary mathematics teachers’ conceptions of function by McCulloch, Allison W., Lovett, Jennifer N., Meagher, Michael S., Sherman, Milan F.

“…Preservice mathematics teachers, like all learners, have well documented difficulties with the concept of function. We designed an applet-based task to…”
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Enhancement of protein secretion in Pichia pastoris by overexpression of protein disulfide isomerase by Inan, Mehmet, Aryasomayajula, Dinesh, Sinha, Jayanta, Meagher, Michael M.

“…A potential vaccine candidate, Necator americanus secretory protein (Na‐ASP1), against hookworm infections, has been expressed in Pichia pastoris. Na‐ASP1, a…”
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Development and Optimization of a Hydrophobic Interaction Chromatography-Based Method of AAV Harvest, Capture, and Recovery by McNally, David J., Piras, Bryan A., Willis, Catherine M., Lockey, Timothy D., Meagher, Michael M.

“…With many ongoing clinical trials utilizing adeno-associated virus (AAV) gene therapy, it is necessary to find scalable and serotype-independent primary…”
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A Quadratic to a Quadratic? This Is New by Meagher, Michael S, Edwards, Michael Todd, Özgün-Koca, S. Asli

“…Too often, high school algebra students encounter topics in a discrete, disconnected fashion. In the authors' first years of teaching, they found students to…”
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A Phase 1 and pharmacokinetic study evaluating daily or weekly schedules of the humanized anti-GD2 antibody hu14.18K322A in recurrent/refractory solid tumors by Bishop, Michael W, Hutson, Paul R, Hank, Jacquelyn A, Sondel, Paul M, Furman, Wayne L, Meagher, Michael M, Navid, Fariba, Santana, Victor M

“…Hu14.18K322A is a humanized anti-GD2 monoclonal antibody with a single point mutation that reduces complement-mediated cytotoxicity, with a maximum tolerated…”
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Fed-batch fermentation of GM-CSF-producing glycoengineered Pichia pastoris under controlled specific growth rate by Jacobs, Pieter P, Inan, Mehmet, Festjens, Nele, Haustraete, Jurgen, Van Hecke, Annelies, Contreras, Roland, Meagher, Michael M, Callewaert, Nico

“…Yeast expression systems with altered N-glycosylation are now available to produce glycoproteins with homogenous, defined N-glycans. However, data on the…”
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Lentiviral Vector Production from a Stable Packaging Cell Line Using a Packed Bed Bioreactor by Powers, Alicia D., Drury, Jason E., Hoehamer, Christopher F., Lockey, Timothy D., Meagher, Michael M.

“…Self-inactivating lentiviral vectors (LVVs) are used regularly for genetic modification of cells, including T cells and hematopoietic stem cells for cellular…”
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Causes of proteolytic degradation of secreted recombinant proteins produced in methylotrophic yeast Pichia pastoris: Case study with recombinant ovine interferon-τ by Sinha, Jayanta, Plantz, Bradley A., Inan, Mehmet, Meagher, Michael M.

“…It was observed that during fermentative production of recombinant ovine interferon‐τ (r‐oIFN‐τ) in Pichia pastoris, a secreted recombinant protein, the…”
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Safety and immunogenicity of an intranasal sendai virus-based vaccine for human parainfluenza virus type I and respiratory syncytial virus (SeVRSV) in adults by Scaggs Huang, Felicia, Bernstein, David I, Slobod, Karen S, Portner, Allen, Takimoto, Toru, Russell, Charles J, Meagher, Michael, Jones, Bart G, Sealy, Robert E, Coleclough, Christopher, Branum, Kristen, Dickey, Michelle, Buschle, Kristen, McNeal, Monica, Makowski, Mat, Nakamura, Aya, Hurwitz, Julia L

“…SeVRSV is a replication-competent Sendai virus (SeV)-based vaccine carrying the respiratory syncytial virus (RSV) fusion protein (F) gene. Unmanipulated,…”
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Safety and immunogenicity of an intranasal Sendai virus-based human parainfluenza virus type 1 vaccine in 3- to 6-year-old children by Adderson, Elisabeth, Branum, Kristen, Sealy, Robert E, Jones, Bart G, Surman, Sherri L, Penkert, Rhiannon, Freiden, Pamela, Slobod, Karen S, Gaur, Aditya H, Hayden, Randall T, Allison, Kim, Howlett, Nanna, Utech, Jill, Allay, Jim, Knight, James, Sleep, Susan, Meagher, Michael M, Russell, Charles J, Portner, Allen, Hurwitz, Julia L

“…Human parainfluenza virus type 1 (hPIV-1) is the most common cause of laryngotracheobronchitis (croup), resulting in tens of thousands of hospitalizations each…”
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Isolation of Pichia pastoris PIR genes and their utilization for cell surface display and recombinant protein secretion by Pal Khasa, Yogender, Conrad, Sara, Sengul, Mustafa, Plautz, Sarah, Meagher, Michael M, Inan, Mehmet

“…Proteins with internal repeats are highly conserved among budding yeasts. In this study, the isolation of two proteins with internal repeats (PIR) genes, i.e…”
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