Search Results - "Meadows, Sarah"

The phosphoinositide 3′-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia by Hoellenriegel, Julia, Meadows, Sarah A., Sivina, Mariela, Wierda, William G., Kantarjian, Hagop, Keating, Michael J., Giese, Neill, O'Brien, Susan, Yu, Albert, Miller, Langdon L., Lannutti, Brian J., Burger, Jan A.

“…In lymphocytes, the phosphoinositide 3′-kinase (PI3K) isoform p110δ (PI3Kδ) transmits signals from surface receptors, including the B-cell receptor (BCR)…”
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Use of Electronic Cigarettes and Other Tobacco Products Among Active Component Services Members by Smucker, Sierra, Meadows, Sarah O, Beckman, Robin

“…ABSTRACT Introduction e-cigarettes have been touted as a safer alternative to classic cigarettes and other combustible tobacco products. However, a growing…”
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National Diet and Nutrition Survey data reveal a decline in folate status in the United Kingdom population between 2008 and 2019 by Jones, Kerry S, Collins, David, Meadows, Sarah R, Koulman, Albert, Page, Polly

“…Folate is essential for healthy growth and development. Fortification of foods with folic acid can improve folate status and reduce risk of neural tube defects…”
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The validation of an LC-MS/MS method for the quantification of vitamin D metabolites in human milk and their biological variability in Gambian women by Jones, Kerry S, Meadows, Sarah R, Billing, Georgia, Koulman, Albert, Prentice, Ann

“…Vitamin D is required for healthy growth and development, but data on human milk vitamin D content is limited. We describe a liquid chromatography tandem mass…”
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PI3Kδ inhibitor idelalisib in combination with BTK inhibitor ONO/GS-4059 in diffuse large B cell lymphoma with acquired resistance to PI3Kδ and BTK inhibitors by Yahiaoui, Anella, Meadows, Sarah A, Sorensen, Rick A, Cui, Zhi-Hua, Keegan, Kathleen S, Brockett, Robert, Chen, Guang, Quéva, Christophe, Li, Li, Tannheimer, Stacey L

“…Activated B-cell-like diffuse large B-cell lymphoma relies on B-cell receptor signaling to drive proliferation and survival. Downstream of the B-cell receptor,…”
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Occupancy maps of 208 chromatin-associated proteins in one human cell type by Partridge, E. Christopher, Chhetri, Surya B., Prokop, Jeremy W., Ramaker, Ryne C., Jansen, Camden S., Goh, Say-Tar, Mackiewicz, Mark, Newberry, Kimberly M., Brandsmeier, Laurel A., Meadows, Sarah K., Messer, C. Luke, Hardigan, Andrew A., Coppola, Candice J., Dean, Emma C., Jiang, Shan, Savic, Daniel, Mortazavi, Ali, Wold, Barbara J., Myers, Richard M., Mendenhall, Eric M.

“…Transcription factors are DNA-binding proteins that have key roles in gene regulation 1 , 2 . Genome-wide occupancy maps of transcriptional regulators are…”
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CETCh-seq: CRISPR epitope tagging ChIP-seq of DNA-binding proteins by Savic, Daniel, Partridge, E Christopher, Newberry, Kimberly M, Smith, Sophia B, Meadows, Sarah K, Roberts, Brian S, Mackiewicz, Mark, Mendenhall, Eric M, Myers, Richard M

“…Chromatin immunoprecipitation followed by next-generation DNA sequencing (ChIP-seq) is a widely used technique for identifying transcription factor (TF)…”
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PI3Kδ inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma by Meadows, Sarah A., Vega, Francisco, Kashishian, Adam, Johnson, Dave, Diehl, Volker, Miller, Langdon L., Younes, Anas, Lannutti, Brian J.

“…GS-1101 (CAL-101) is an oral PI3Kδ-specific inhibitor that has shown preclinical and clinical activity in non-Hodgkin lymphoma and chronic lymphocytic…”
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CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability by Lannutti, Brian J., Meadows, Sarah A., Herman, Sarah E.M., Kashishian, Adam, Steiner, Bart, Johnson, Amy J., Byrd, John C., Tyner, Jeffrey W., Loriaux, Marc M., Deininger, Mike, Druker, Brian J., Puri, Kamal D., Ulrich, Roger G., Giese, Neill A.

“…Phosphatidylinositol-3-kinase p110δ serves as a central integration point for signaling from cell surface receptors known to promote malignant B-cell…”
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A Validated Regulatory Network for Th17 Cell Specification by Ciofani, Maria, Madar, Aviv, Galan, Carolina, Sellars, MacLean, Mace, Kieran, Pauli, Florencia, Agarwal, Ashish, Huang, Wendy, Parkurst, Christopher N., Muratet, Michael, Newberry, Kim M., Meadows, Sarah, Greenfield, Alex, Yang, Yi, Jain, Preti, Kirigin, Francis K., Birchmeier, Carmen, Wagner, Erwin F., Murphy, Kenneth M., Myers, Richard M., Bonneau, Richard, Littman, Dan R.

“…Th17 cells have critical roles in mucosal defense and are major contributors to inflammatory disease. Their differentiation requires the nuclear hormone…”
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Increasing the availability and utilization of reliable data on population micronutrient (MN) status globally: the MN Data Generation Initiative by Brown, Kenneth H, Moore, Sophie E, Hess, Sonja Y, McDonald, Christine M, Jones, Kerry S, Meadows, Sarah R, Manger, Mari S, Coates, Jennifer, Alayon, Silvia, Osendarp, Saskia JM

“…Micronutrient (MN) deficiencies can produce a broad array of adverse health and functional outcomes. Young, preschool children and women of reproductive age in…”
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Vitamin D Status Increases During Pregnancy and in Response to Vitamin D Supplementation in Rural Gambian Women by Jones, Kerry S, Meadows, Sarah R, Schoenmakers, Inez, Prentice, Ann, Moore, Sophie E

“…Vitamin D is important to maternal, fetal, and infant health, but quality data on vitamin D status in low- and middle-income countries and response to…”
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Delayed Processing of Chilled Whole Blood for 24 Hours Does Not Affect the Concentration of the Majority of Micronutrient Status Biomarkers by Jones, Kerry S, Meadows, Sarah R, Chamberlain, Karen, Parkington, Damon A, Collins, Dave, Page, Polly, Koulman, Albert

“…The measurement of micronutrient status is essential to understand the health of individuals and populations, but there are limited data on the stability of…”
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Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells by Chute, John P, Doan, Phuong, Salter, Alice B, Russell, J Lauren, Lento, William E, Daher, Pamela, Meadows, Sarah K, Muramoto, Garrett G, Chi, Jen-Tsan, Chao, Nelson J, Reya, Tannishtha, Himburg, Heather A

“…A technique for expanding hematopoietic stem cell numbers could have many clinical applications, including improving bone marrow transplantation and recovery…”
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DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions by Huang, Wendy, Thomas, Benjamin, Flynn, Ryan A., Gavzy, Samuel J., Wu, Lin, Kim, Sangwon V., Hall, Jason A., Miraldi, Emily R., Ng, Charles P., Rigo, Frank, Meadows, Sarah, Montoya, Nina R., Herrera, Natalia G., Domingos, Ana I., Rastinejad, Fraydoon, Myers, Richard M., Fuller-Pace, Frances V., Bonneau, Richard, Chang, Howard Y., Acuto, Oreste, Littman, Dan R.

“…T helper 17 (T H 17) lymphocytes protect mucosal barriers from infections, but also contribute to multiple chronic inflammatory diseases. Their differentiation…”
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Stability and Change in Family Structure and Maternal Health Trajectories by Meadows, Sarah O., McLanahan, Sara S., Brooks-Gunn, Jeanne

“…Recent increases in births to unmarried parents, and the instability surrounding these relationships, have raised concerns about the possible health effects…”
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Family Structure Transitions and Maternal Parenting Stress by Cooper, Carey E., McLanahan, Sara S., Meadows, Sarah O., Brooks-Gunn, Jeanne

“…Data from the Fragile Families and Child Wellbeing Study (N = 4,176) are used to examine family structure transitions and maternal parenting stress. Using…”
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Intricate interplay between astrocytes and motor neurons in ALS by Phatnani, Hemali P, Guarnieri, Paolo, Friedman, Brad A, Carrasco, Monica A, Muratet, Michael, O'Keeffe, Sean, Nwakeze, Chiamaka, Pauli-Behn, Florencia, Newberry, Kimberly M, Meadows, Sarah K, Tapia, Juan Carlos, Myers, Richard M, Maniatis, Tom

“…ALS results from the selective and progressive degeneration of motor neurons. Although the underlying disease mechanisms remain unknown, glial cells have been…”
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The effect of an acute bout of exercise on circulating vitamin D metabolite concentrations: a randomised crossover study in healthy adults by Davies, Sophie E., Perkin, Oliver J., Betts, James A., Gonzalez, Javier T., Hewison, Martin, Jenkinson, Carl, Jones, Kerry S., Meadows, Sarah R., Parkington, Damon A., Koulman, Albert, Thompson, Dylan

“…The effect of acute exercise on circulating concentrations of vitamin D metabolites is unclear. To address this knowledge gap, we examined the effect of a bout…”
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Marital Trajectories and Mortality Among US Adults by Dupre, Matthew E., Beck, Audrey N., Meadows, Sarah O.

“…More than a century of empirical evidence links marital status to mortality. However, the hazards of dying associated with long-term marital trajectories and…”
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