Search Results - "Meadows, John C."

Phosphodependent Recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 Kinase Maintains the Spindle Checkpoint by Shepperd, Lindsey A., Meadows, John C., Sochaj, Alicja M., Lancaster, Theresa C., Zou, Juan, Buttrick, Graham J., Rappsilber, Juri, Hardwick, Kevin G., Millar, Jonathan B.A.

“…The spindle assembly checkpoint (SAC) is the major surveillance system that ensures that sister chromatids do not separate until all chromosomes are correctly…”
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Interplay between mitotic kinesins and the Aurora kinase-PP1 (protein phosphatase 1) axis by Meadows, John C

“…Correct transmission of genetic information from mother to daughter cells is necessary for development and survival. Accurate segregation is achieved by…”
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Bub3-Bub1 Binding to Spc7/KNL1 Toggles the Spindle Checkpoint Switch by Licensing the Interaction of Bub1 with Mad1-Mad2 by Mora-Santos, Maria del Mar, Hervas-Aguilar, America, Sewart, Katharina, Lancaster, Theresa C., Meadows, John C., Millar, Jonathan B.A.

“…The spindle assembly checkpoint (SAC) ensures that sister chromatids do not separate until all chromosomes are attached to spindle microtubules and…”
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Spindle Checkpoint Silencing Requires Association of PP1 to Both Spc7 and Kinesin-8 Motors by Meadows, John C., Shepperd, Lindsey A., Vanoosthuyse, Vincent, Lancaster, Theresa C., Sochaj, Alicja M., Buttrick, Graham J., Hardwick, Kevin G., Millar, Jonathan B.A.

“…The spindle checkpoint is the prime cell-cycle control mechanism that ensures sister chromatids are bioriented before anaphase takes place. Aurora B kinase,…”
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Sharpening the anaphase switch by Meadows, John C, Millar, Jonathan B A

“…The segregation of sister chromatids during mitosis is one of the most easily visualized, yet most remarkable, events during the life cycle of a cell. The…”
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Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast by Meadows, John C., Lancaster, Theresa C., Buttrick, Graham J., Sochaj, Alicja M., Messin, Liam J., del Mar Mora-Santos, Maria, Hardwick, Kevin G., Millar, Jonathan B.A.

“…The onset of anaphase is triggered by activation of the anaphase-promoting complex/cyclosome (APC/C) following silencing of the spindle assembly checkpoint…”
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Cell Biology: Polar Expeditions for PP1 by Meadows, John C., Millar, Jonathan B.A.

“…A new study shows that phospho-dependent expulsion of type-1-phosphatase (PP1) from the spindle pole by Fin1 (NIMA) kinase ensures switch-like activation of…”
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Latrunculin A delays anaphase onset in fission yeast by disrupting an Ase1-independent pathway controlling mitotic spindle stability by Meadows, John C, Millar, Jonathan

“…It has been proposed previously that latrunculin A, an inhibitor of actin polymerization, delays the onset of anaphase by causing spindle misorientation in…”
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The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast by Sanchez-Perez, Isabel, Renwick, Steven J, Crawley, Karen, Karig, Inga, Buck, Vicky, Meadows, John C, Franco-Sanchez, Alejandro, Fleig, Ursula, Toda, Takashi, Millar, Jonathan B A

“…We identified a truncated allele of dam1 as a multicopy suppressor of the sensitivity of cdc13‐117 (cyclin B) and mal3‐1 (EB‐1) cells to thiabendazole, a…”
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Dam1/DASH complex is required for the retrieval of unclustered kinetochores in fission yeast by Franco, Alejandro, Meadows, John C, Millar, Jonathan B.A

“…In fission yeast centromeres cluster at the nuclear envelope in a region underlying the spindle pole body during interphase, an arrangement known as a Rabl…”
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Some assembly required: Redefining the mitotic checkpoint by Meadows, John C., Millar, Jonathan B. A.

“…The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation…”
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Plo1 phosphorylates Dam1 to promote chromosome bi-orientation in fission yeast by Buttrick, Graham J, Lancaster, Theresa C, Meadows, John C, Millar, Jonathan B A

“…The fungal-specific heterodecameric outer kinetochore DASH complex facilitates the interaction of kinetochores with spindle microtubules. In budding yeast,…”
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Bub3p facilitates spindle checkpoint silencing in fission yeast by Vanoosthuyse, Vincent, Meadows, John C, van der Sar, Sjaak J A, Millar, Jonathan B A, Hardwick, Kevin G

“…Although critical for spindle checkpoint signaling, the role kinetochores play in anaphase promoting complex (APC) inhibition remains unclear. Here we show…”
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Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B by Buttrick, Graham J, Meadows, John C, Lancaster, Theresa C, Vanoosthuyse, Vincent, Shepperd, Lindsey A, Hoe, Kwang-Lae, Kim, Dong-Uk, Park, Han-Oh, Hardwick, Kevin G, Millar, Jonathan B A

“…Type 1 phosphatase (PP1) antagonizes Aurora B kinase to stabilize kinetochore-microtubule attachments and to silence the spindle checkpoint. We screened for…”
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Opposing kinesin complexes queue at plus tips to ensure microtubule catastrophe at cell ends by Meadows, John C, Messin, Liam J, Kamnev, Anton, Lancaster, Theresa C, Balasubramanian, Mohan K, Cross, Robert A, Millar, Jonathan BA

“…In fission yeast, the lengths of interphase microtubule (iMT) arrays are adapted to cell length to maintain cell polarity and to help centre the nucleus and…”
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Meeting report: mitosis and nuclear structure by Meadows, John C, Graumann, Katja, Platani, Melpi, Schweizer, Nina, Shimi, Takeshi, Vagnarelli, Paola, Gatlin, Jesse C

“…The Company of Biologists Workshop entitled 'Mitosis and Nuclear Structure' was held at Wiston House, West Sussex in June 2013. It provided a unique and timely…”
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Science For All by Messin, Liam J., Meadows, John C.

“…Science is the best method humanity has for understanding the universe and our place in it. However, despite its astonishing achievements, the implementation…”
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Estimation of Uptake Rate Constants for PCB Congeners Accumulated by Semipermeable Membrane Devices and Brown Trout (Salmo trutta) by Meadows, John C, Echols, Kathy R, Huckins, James N, Borsuk, Frank A, Carline, Robert F, Tillitt, Donald E

“…The triolein-filled semipermeable membrane device (SPMD) is a simple and effective method of assessing the presence of waterborne hydrophobic chemicals. Uptake…”
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Comparing Polychlorinated Biphenyl Concentrations and Patterns in the Saginaw River Using Sediment, Caged Fish, and Semipermeable Membrane Devices by Echols, Kathy R, Gale, Robert W, Schwartz, Ted R, Huckins, James N, Williams, Lisa L, Meadows, John C, Morse, Douglas, Petty, Jimmie D, Orazio, Carl E, Tillitt, Donald E

“…Three techniques of assessing bioavailable polychlorinated biphenyls (PCBs) in the Saginaw River, MI, were compared:  sediments, caged fish, and semipermeable…”
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Polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in tree swallows from the upper Hudson River, New York State, USA by Secord, Anne L., McCarty, John P., Echols, Kathy R., Meadows, John C., Gale, Robert W., Tillitt, Donald E.

“…The upper Hudson River of New York State, USA, is contaminated with polychlorinated biphenyls (PCBs) as a result of industrial discharges throughout the latter…”
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