Search Results - "Meade, Thomas"

Molecular Magnetic Resonance Imaging with Gd(III)-Based Contrast Agents: Challenges and Key Advances by Li, Hao, Meade, Thomas J

“…In an era of personalized medicine, the clinical community has become increasingly focused on understanding diseases at the cellular and molecular levels…”
Get full text

Lanthanide Probes for Bioresponsive Imaging by Heffern, Marie C, Matosziuk, Lauren M, Meade, Thomas J

“…Heffern et al investigate luminescent and magnetic lanthanide probes and their use in bioresponsive imaging. Aspects of multimodal imaging and radiometals are…”
Get full text

Bimodal Fluorescence-Magnetic Resonance Contrast Agent for Apoptosis Imaging by Li, Hao, Parigi, Giacomo, Luchinat, Claudio, Meade, Thomas J

“…Effective cancer therapy largely depends on inducing apoptosis in cancer cells via chemotherapy and/or radiation. Monitoring apoptosis in real-time provides…”
Get full text

Electrochemistry of redox-active self-assembled monolayers by Eckermann, Amanda L., Feld, Daniel J., Shaw, Justine A., Meade, Thomas J.

“…Redox-active self-assembled monolayers (SAMs) provide an excellent platform for investigating electron transfer kinetics. Using a well-defined bridge, a redox…”
Get full text

Bioresponsive, Cell-Penetrating, and Multimeric MR Contrast Agents by Major, Jody L, Meade, Thomas J

“…Magnetic resonance imaging (MRI) has become increasingly popular in experimental molecular imaging and clinical radiology because it is non-invasive and…”
Get full text

Molecular Engineering of Self-Immolative Bioresponsive MR Probes by Tang, Jian-Hong, Li, Hao, Yuan, Chaonan, Parigi, Giacomo, Luchinat, Claudio, Meade, Thomas J.

“…Real-time detection of bio-event in whole animals provides essential information for understanding biological and therapeutic processes. Magnetic resonance…”
Get full text

Magnetic Resonance Imaging of PSMA-Positive Prostate Cancer by a Targeted and Activatable Gd(III) MR Contrast Agent by Li, Hao, Luo, Dong, Yuan, Chaonan, Wang, Xinning, Wang, Jing, Basilion, James P, Meade, Thomas J

“…Prostate-specific membrane antigen (PSMA) is a transmembrane protein that is highly expressed in aggressive prostate cancer (PCa) and has been extensively…”
Get full text

Gd()-Pt() theranostic contrast agents for tandem MR imaging and chemotherapy by Adams, Casey J, Meade, Thomas J

“…Pt( iv ) prodrugs have emerged as versatile therapeutics for addressing issues regarding off-target toxicity and the chemoresistance of classic Pt( ii ) drugs…”
Get full text

Inhibition of Amyloid‑β Aggregation by Cobalt(III) Schiff Base Complexes: A Computational and Experimental Approach by Iscen, Aysenur, Brue, Christopher R, Roberts, Kaleigh F, Kim, Joy, Schatz, George C, Meade, Thomas J

“…Coordination complexes have emerged as prominent modulators of amyloid aggregation via their interaction with the N-terminal histidine residues of amyloid-β…”
Get full text

Development of Ln(III) Derivatives as 19 F Parashift Probes by Kaster, Megan A, Caldwell, Michael A, Meade, Thomas J

“…F parashift probes with paramagnetically shifted reporter nuclei provide attractive platforms to develop molecular imaging probes. These probes enable…”
Get full text

Development of Ln(III) Derivatives as 19F Parashift Probes by Kaster, Megan A., Caldwell, Michael A., Meade, Thomas J.

“…19F parashift probes with paramagnetically shifted reporter nuclei provide attractive platforms to develop molecular imaging probes. These probes enable…”
Get full text

Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma by Jensen, Samuel A, Day, Emily S, Ko, Caroline H, Hurley, Lisa A, Luciano, Janina P, Kouri, Fotini M, Merkel, Timothy J, Luthi, Andrea J, Patel, Pinal C, Cutler, Joshua I, Daniel, Weston L, Scott, Alexander W, Rotz, Matthew W, Meade, Thomas J, Giljohann, David A, Mirkin, Chad A, Stegh, Alexander H

“…Glioblastoma multiforme (GBM) is a neurologically debilitating disease that culminates in death 14 to 16 months after diagnosis. An incomplete understanding of…”
Get more information

Multimodal MRI contrast agents by Frullano, Luca, Meade, Thomas J

Get full text

Targeted Radiosensitizers for MR-Guided Radiation Therapy of Prostate Cancer by Luo, Dong, Johnson, Andrew, Wang, Xinning, Li, Hao, Erokwu, Bernadette O, Springer, Sarah, Lou, Jason, Ramamurthy, Gopalakrishnan, Flask, Chris A, Burda, Clemens, Meade, Thomas J, Basilion, James P

“…Adjuvant radiotherapy is frequently prescribed to treat cancer. To minimize radiation-related damage to healthy tissue, it requires high precision in tumor…”
Get full text

Targeted inactivation of Snail family EMT regulatory factors by a Co(III)-Ebox conjugate by Harney, Allison S, Meade, Thomas J, LaBonne, Carole

“…Snail family proteins are core EMT (epithelial-mesenchymal transition) regulatory factors that play essential roles in both development and disease processes…”
Get full text

Multimeric Near IR–MR Contrast Agent for Multimodal In Vivo Imaging by Harrison, Victoria S. R, Carney, Christiane E, MacRenaris, Keith W, Waters, Emily A, Meade, Thomas J

“…Multiple imaging modalities are often required for in vivo imaging applications that require both high probe sensitivity and excellent spatial and temporal…”
Get full text

Synthesis of Multimeric MR Contrast Agents for Cellular Imaging by Song, Ying, Kohlmeir, Ellen K, Meade, Thomas J

“…We have prepared a series of molecular multimeric MR contrast agents for cell labeling that are easy to synthesize, relatively low molecular weight, and…”
Get full text

Injectable biomimetic liquid crystalline scaffolds enhance muscle stem cell transplantation by Sleep, Eduard, Cosgrove, Benjamin D., McClendon, Mark T., Preslar, Adam T., Chen, Charlotte H., Sangji, M. Hussain, Pérez, Charles M. Rubert, Haynes, Russell D., Meade, Thomas J., Blau, Helen M., Stupp, Samuel I.

“…Muscle stem cells are a potent cell population dedicated to efficacious skeletal muscle regeneration, but their therapeutic utility is currently limited by…”
Get full text

Advances in optical and electrochemical techniques for biomedical imaging by Long, Yi-Tao, Meade, Thomas J

“…Yi-Tao Long and Thomas J. Meade introduce the Chemical Science retrospective themed collection on advances in optical and electrochemical techniques for…”
Get full text

Self‐Immolative Activation of β‐Galactosidase‐Responsive Probes for In Vivo MR Imaging in Mouse Models by Lilley, Laura M., Kamper, Sarah, Caldwell, Michael, Chia, Zer Keen, Ballweg, David, Vistain, Luke, Krimmel, Jeffrey, Mills, Teresa Anne, MacRenaris, Keith, Lee, Paul, Waters, Emily Alexandria, Meade, Thomas J.

“…Our lab has developed a new series of self‐immolative MR agents for the rapid detection of enzyme activity in mouse models expressing β‐galactosidase (β‐gal)…”
Get full text