Search Results - "Meade, D."

Physiological factors characterizing heat-vulnerable older adults: A narrative review by Meade, Robert D., Akerman, Ashley P., Notley, Sean R., McGinn, Ryan, Poirier, Paul, Gosselin, Pierre, Kenny, Glen P.

“…•Heatwaves are associated with stark elevations in morbidity and mortality.•Older adults are at particular risk of multiple pathophysiological…”
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R2DT is a framework for predicting and visualising RNA secondary structure using templates by Sweeney, Blake A., Hoksza, David, Nawrocki, Eric P., Ribas, Carlos Eduardo, Madeira, Fábio, Cannone, Jamie J., Gutell, Robin, Maddala, Aparna, Meade, Caeden D., Williams, Loren Dean, Petrov, Anton S., Chan, Patricia P., Lowe, Todd M., Finn, Robert D., Petrov, Anton I.

“…Non-coding RNAs (ncRNA) are essential for all life, and their functions often depend on their secondary (2D) and tertiary structure. Despite the abundance of…”
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Discrimination of breast cancer from benign tumours using Raman spectroscopy by Lyng, Fiona M, Traynor, Damien, Nguyen, Thi Nguyet Que, Meade, Aidan D, Rakib, Fazle, Al-Saady, Rafif, Goormaghtigh, Erik, Al-Saad, Khalid, Ali, Mohamed H

“…Breast cancer is the most common cancer among women worldwide, with an estimated 1.7 million cases and 522,000 deaths in 2012. Breast cancer is diagnosed by…”
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Pertussis Resurgence: Perspectives From the Working Group Meeting on Pertussis on the Causes, Possible Paths Forward, and Gaps in Our Knowledge by Burns, Drusilla L., Meade, Bruce D., Messionnier, Nancy E.

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Discrimination of immune cell activation using Raman micro-spectroscopy in an in-vitro & ex-vivo model by Chaudhary, Neha, Nguyen, Thi Nguyet Que, Cullen, Daniel, Meade, Aidan D., Wynne, Claire

“…[Display omitted] •Raman spectroscopy is an effective method for the differentiation of immune cells.•Cell lines and primary cells in both resting and…”
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Phenotypic and Functional Characteristics of Exosomes Derived from Irradiated Mouse Organs and Their Role in the Mechanisms Driving Non-Targeted Effects by Tuncay Cagatay, Seda, Mayah, Ammar, Mancuso, Mariateresa, Giardullo, Paola, Pazzaglia, Simonetta, Saran, Anna, Daniel, Amuthachelvi, Traynor, Damien, Meade, Aidan D, Lyng, Fiona, Tapio, Soile, Kadhim, Munira

“…Molecular communication between irradiated and unirradiated neighbouring cells initiates radiation-induced bystander effects (RIBE) and out-of-field (abscopal)…”
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Evidence for cyclooxygenase‐dependent sweating in young males during intermittent exercise in the heat by Fujii, Naoto, McGinn, Ryan, Stapleton, Jill M., Paull, Gabrielle, Meade, Robert D., Kenny, Glen P.

“…Key points Previous studies implicate nitric oxide (NO) in the control of sweating during exercise in the heat; however, it is unclear whether cyclooxygenase…”
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Use of coefficient of variation in assessing variability of quantitative assays by Reed, George F, Lynn, Freyja, Meade, Bruce D

“…We have derived the mathematical relationship between the coefficient of variation associated with repeated measurements from quantitative assays and the…”
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Development of a high throughput (HT) Raman spectroscopy method for rapid screening of liquid blood plasma from prostate cancer patients by Medipally, Dinesh K R, Maguire, Adrian, Bryant, Jane, Armstrong, John, Dunne, Mary, Finn, Marie, Lyng, Fiona M, Meade, Aidan D

“…Extensive research has been undertaken on the examination of tissue biopsies using vibrational spectroscopic techniques. However, fewer studies have focused on…”
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Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays by Wilham, Jason M, Orrú, Christina D, Bessen, Richard A, Atarashi, Ryuichiro, Sano, Kazunori, Race, Brent, Meade-White, Kimberly D, Taubner, Lara M, Timmes, Andrew, Caughey, Byron

“…A major problem for the effective diagnosis and management of prion diseases is the lack of rapid high-throughput assays to measure low levels of prions. Such…”
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iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat by Fujii, Naoto, Meade, Robert D, Alexander, Lacy M, Akbari, Pegah, Foudil-Bey, Imane, Louie, Jeffrey C, Boulay, Pierre, Kenny, Glen P

“…Nitric oxide synthase (NOS) contributes to sweating and cutaneous vasodilation during exercise in younger adults. We hypothesized that endothelial NOS (eNOS)…”
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Possible Options for New Pertussis Vaccines by Meade, Bruce D., Plotkin, Stanley A., Locht, Camille

“…Increasing evidence that the currently available acellular pertussis vaccines are not providing optimal control of pertussis in the United States and many…”
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Application of Advanced Non-Linear Spectral Decomposition and Regression Methods for Spectroscopic Analysis of Targeted and Non-Targeted Irradiation Effects in an In-Vitro Model by Slattery, Ciara, Nguyen, Khanh, Shields, Laura, Vega-Carrascal, Isabel, Singleton, Sean, Lyng, Fiona M., McClean, Brendan, Meade, Aidan D.

“…Irradiation of the tumour site during treatment for cancer with external-beam ionising radiation results in a complex and dynamic series of effects in both the…”
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Chronic wasting disease agents in nonhuman primates by Race, Brent, Meade-White, Kimberly D, Phillips, Katie, Striebel, James, Race, Richard, Chesebro, Bruce

“…Chronic wasting disease is a prion disease of cervids. Assessment of its zoonotic potential is critical. To evaluate primate susceptibility, we tested monkeys…”
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Do the Threshold Limit Values for Work in Hot Conditions Adequately Protect Workers? by MEADE, ROBERT D, POIRIER, MARTIN P, FLOURIS, ANDREAS D, HARDCASTLE, STEPHEN G, KENNY, GLEN P

“…PURPOSEWe evaluated core temperature responses and the change in body heat content (ΔHb) during work performed according to the ACGIH threshold limit values…”
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Are undesirable contact kinematics minimized after kinematically aligned total knee arthroplasty? An intersurgeon analysis of consecutive patients by Howell, Stephen M., Hodapp, Esther E., Vernace, Joseph V., Hull, Maury L., Meade, Thomas D.

“…Purpose Tibiofemoral contact kinematics or knee implant motions have a direct influence on patient function and implant longevity and should be evaluated for…”
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The physiological strain incurred during electrical utilities work over consecutive work shifts in hot environments: A case report by Meade, Robert D., D'Souza, Andrew W., Krishen, Lovely, Kenny, Glen P.

“…Purpose: In this article, we evaluated physiological strain in electrical utilities workers during consecutive work shifts in hot outdoor conditions. Methods:…”
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Association between haemoglobin A1c and whole‐body heat loss during exercise‐heat stress in physically active men with type 2 diabetes by Kirby, Nathalie V., Meade, Robert D., Poirier, Martin P., Sigal, Ronald J., Boulay, Pierre, Kenny, Glen P.

“…New Findings What is the central question of this study? Is the impairment in heat dissipation during exercise observed in men with type 2 diabetes related to…”
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The interactive contributions of Na+/K+‐ATPase and nitric oxide synthase to sweating and cutaneous vasodilatation during exercise in the heat by Louie, Jeffrey C., Fujii, Naoto, Meade, Robert D., Kenny, Glen P.

“…Key points Nitric oxide synthase (NOS) contributes to sweating and cutaneous vasodilatation during exercise in the heat. Similarly, reports show that…”
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Studies of chemical fixation effects in human cell lines using Raman microspectroscopy by Meade, Aidan D, Clarke, Colin, Draux, Florence, Sockalingum, Ganesh D, Manfait, Michel, Lyng, Fiona M, Byrne, Hugh J

“…The in vitro study of cellular species using Raman spectroscopy has proven a powerful non-invasive modality for the analysis of cell constituents and…”
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