Search Results - "Mead, J. R."

NRF2 as a therapeutic opportunity to impact in the molecular roadmap of ALS by Jiménez-Villegas, J., Ferraiuolo, L., Mead, R.J., Shaw, P.J., Cuadrado, A., Rojo, A.I.

“…Amyotrophic Lateral Sclerosis (ALS) is a devastating heterogeneous disease with still no convincing therapy. To identify the most strategically significant…”
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The Membrane Attack Complex of Complement Causes Severe Demyelination Associated with Acute Axonal Injury by Mead, Richard J, Singhrao, Sim K, Neal, James W, Lassmann, H, Morgan, B. Paul

“…Complement is implicated in pathology in the human demyelinating disease multiple sclerosis and in animal models that mimic the demyelination seen in multiple…”
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Cryptosporidium parvum antigens induce mouse and human dendritic cells to generate Th1-enhancing cytokines by BEDI, B., MEAD, J. R.

“…Summary Cryptosporidium parvum is an opportunistic intracellular parasite that causes mild to severe diarrhoea, which can be life‐threatening in an…”
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Effects of ozone, chlorine dioxide, chlorine, and monochloramine on Cryptosporidium parvum oocyst viability by KORICH, D. G, MEAD, J. R, MADORE, M. S, SINCLAIR, N. A, STERLING, C. R

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Use of Trichomonas vaginalis Clinical Isolates to Evaluate Correlation of Gene Expression and Metronidazole Resistance by Mead, J. R, Fernadez, M, Romagnoli, P. A, Secor, W. E

“…We investigated whether variations in gene expression of enzymes associated with anaerobic resistance of laboratory-derived strains of Trichomonas vaginalis…”
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Amelioration of Cryptosporidium parvum Infection In Vitro and In Vivo by Targeting Parasite Fatty Acyl-Coenzyme A Synthetases by Guo, Fengguang, Zhang, Haili, Fritzler, Jason M., Rider, S. Dean, Xiang, Lixin, McNair, Nina N., Mead, Jan R., Zhu, Guan

“…Background. Cryptosporidium is emerging as 1 of the 4 leading diarrheal pathogens in children in developing countries. Its infections in patients with AIDS can…”
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Susceptibility differences to Cryptosporidium parvum infection in two strains of gamma interferon knockout mice by Mead, J.R, You, X.D

“…Differences in susceptibility to cryptosporidial infections were investigated between 2 strains of gamma interferon knockout (GKO) mice. Male C57BL/6J-Ifgtml@…”
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Characterization of experimental Cryptosporidium parvum infection in IFN-gamma knockout mice by You, X, Mead, J R

“…Severe cryptosporidial infections were produced in gamma interferon (IFN-gamma) knockout mice. Mean oocyst shedding increased from 332 to 30,717 oocysts/100…”
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Chronic Cryptosporidium parvum Infections in Congenitally Immunodeficient SCID and Nude Mice by Mead, Jan R., Arrowood, Michael J., Sidwell, Robert W., Healey, Mark C.

“…Severe combined immune deficient (SCID) and athymic National Institutes of Health (NIH)-1lI (bg/nu/xid) mice were evaluated for susceptibility to…”
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Human T and B Cell Immunoreactivity to a Recombinant 23-kDa Cryptosporidium parvum Antigen by SMITH, L. M, PRIEST, J. W, LAMMIE, P. J, MEAD, J. R

“…Cryptosporidial infection in humans results in parasite-specific IgG, IgM, and IgA antibody responses, but little is known of the cell-mediated immune…”
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Effects of immune colostrum and orally administered antisporozoite monoclonal antibodies on the outcome of Cryptosporidium parvum infections in neonatal mice by Arrowood, M.J. (University of Arizona, Tucson, AZ), Mead, J.R, Mahrt, J.L, Sterling, C.R

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Cryptosporidium andersoni n. sp. (Apicomplexa: Cryptosporiidae) from Cattle, Bos taurus by Lindsay, David S, Upton, Steve J, Owens, Douglas S, Morgan, Una M, Mead, Jan R, Blagburn, Byron L

“…A new species of Cryptosporidium is described from the feces of domestic cattle, Bos taurus. Oocysts are structurally similar to those of Cryptosporidium muris…”
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Evaluation of maduramicin and alborixin in a SCID mouse model of chronic cryptosporidiosis by MEAD, J. R, XIANGDONG YOU, PHARR, J. E, BELENKAYA, Y, ARROWOOD, M. J, FALLON, M. T, SCHINAZI, R. F

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Antigens of Cryptosporidium sporozoites recognized by immune sera of infected animals and humans by Mead, J.R, Arrowood, M.J, Sterling, C.R

“…The humoral response of humans, calves, and horses to Cryptosporidium sporozoite antigens was evaluated using a western blot technique. Sera from calves,…”
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Treatment of murine cytomegalovirus infections in severe combined immunodeficient mice with ganciclovir, (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine, interferon, and bropirimine by Smee, D F, Morris, J L, Leonhardt, J A, Mead, J R, Holy, A, Sidwell, R W

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Mucosal cytokine and antigen‐specific responses to Cryptosporidium parvum in IL‐12p40 KO mice by Ehigiator, H. N., Romagnoli, P., Borgelt, K., Fernandez, M., McNair, N., Secor, W. E., Mead, J. R.

“…SUMMARY Studies of cellular immune responses to Cryptosporidium parvum have been limited in part by lack of suitable animal models. IL‐12p40–/–mice are…”
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Infection dynamics and clinical features of cryptosporidiosis in SCID mice by MEAD, J. R, ILKSOY, N, XIANGDONG YOU, BELENKAYA, Y, ARROWOOD, M. J, FALLON, M. T, SCHINAZI, R. F

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The mode of toxic action of the pesticide Gliftor: The metabolism of 1,3-difluoroacetone to (−)-erythro-fluorocitrate by Menon, K. I., Feldwick, M. G., Noakes, P. S., Mead, R. J.

“…The biochemical toxicology of 1,3‐difluoroacetone, a known metabolite of the major ingredient of the pesticide Gliftor (1,3‐difluoro‐2‐propanol), was…”
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Endemic Cryptosporidium and Giardia lamblia infections in a Thai orphanage by Janoff, E N, Mead, P S, Mead, J R, Echeverria, P, Bodhidatta, L, Bhaibulaya, M, Sterling, C R, Taylor, D N

“…We conducted a point prevalence survey for enteric protozoa in 205 institutionalized orphans 1-61 months of age in Bangkok, Thailand. Cryptosporidium was…”
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Identification of isolate-specific sporozoite proteins of Cryptosporidium parvum by two-dimensional gel electrophoresis by MEAD, J. R, HUMPHREYS, R. C, SAMMONS, D. W, STERLING, C. R

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