Search Results - "Mead, J."

Myeloproliferative neoplasm stem cells by Mead, Adam J., Mullally, Ann

“…Myeloproliferative neoplasms (MPNs) arise in the hematopoietic stem cell (HSC) compartment as a result of the acquisition of somatic mutations in a single HSC…”
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Spherical collapse, formation hysteresis and the deeply non-linear cosmological power spectrum by Mead, A J

“…I examine differences in non-linear structure formation between cosmological models that share a z = 0 linear power spectrum in both shape and amplitude, but…”
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Including beyond-linear halo bias in halo models by Mead, A J, Verde, L

“…ABSTRACT We derive a simple prescription for including beyond-linear halo bias within the standard, analytical halo-model power spectrum calculation. This…”
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An accurate halo model for fitting non-linear cosmological power spectra and baryonic feedback models by Mead, A. J., Peacock, J. A., Heymans, C., Joudaki, S., Heavens, A. F.

“…We present an optimized variant of the halo model, designed to produce accurate matter power spectra well into the non-linear regime for a wide range of…”
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Single-cell approaches reveal novel cellular pathways for megakaryocyte and erythroid differentiation by Psaila, Bethan, Mead, Adam J.

“…The classical model of hematopoiesis proposes a hierarchy in which a small number of multipotent hematopoietic stem cells (HSCs) maintain all blood lineages by…”
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On the road to percent accuracy: non-linear reaction of the matter power spectrum to dark energy and modified gravity by Cataneo, M, Lombriser, L, Heymans, C, Mead, A J, Barreira, A, Bose, S, Li, B

“…ABSTRACT We present a general method to compute the non-linear matter power spectrum for dark energy (DE) and modified gravity scenarios with per cent-level…”
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Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells by Böiers, Charlotta, Carrelha, Joana, Lutteropp, Michael, Luc, Sidinh, Green, Joanna C.A., Azzoni, Emanuele, Woll, Petter S., Mead, Adam J., Hultquist, Anne, Swiers, Gemma, Perdiguero, Elisa Gomez, Macaulay, Iain C., Melchiori, Luca, Luis, Tiago C., Kharazi, Shabnam, Bouriez-Jones, Tiphaine, Deng, Qiaolin, Pontén, Annica, Atkinson, Deborah, Jensen, Christina T., Sitnicka, Ewa, Geissmann, Frederic, Godin, Isabelle, Sandberg, Rickard, de Bruijn, Marella F.T.R., Jacobsen, Sten Eirik W.

“…In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens…”
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Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia by Giustacchini, Alice, Thongjuea, Supat, Barkas, Nikolaos, Woll, Petter S, Povinelli, Benjamin J, Booth, Christopher A G, Sopp, Paul, Norfo, Ruggiero, Rodriguez-Meira, Alba, Ashley, Neil, Jamieson, Lauren, Vyas, Paresh, Anderson, Kristina, Segerstolpe, Åsa, Qian, Hong, Olsson-Strömberg, Ulla, Mustjoki, Satu, Sandberg, Rickard, Jacobsen, Sten Eirik W, Mead, Adam J

“…Applying a new, more sensitive single-cell transcriptomics method to diagnosis, remission and progression samples from patients with chronic myeloid leukemia…”
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ADAMTS proteins in human disorders by Mead, Timothy J., Apte, Suneel S.

“…ADAMTS proteins are a superfamily of 26 secreted molecules comprising two related, but distinct families. ADAMTS proteases are zinc metalloendopeptidases, most…”
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Proliferation assays (BrdU and EdU) on skeletal tissue sections by Mead, Timothy J, Lefebvre, Véronique

“…Assessing cell proliferation in situ is an important phenotyping component of skeletal tissues from development to adult stages and disease. Various methods…”
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Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways by Psaila, Bethan, Barkas, Nikolaos, Iskander, Deena, Roy, Anindita, Anderson, Stacie, Ashley, Neil, Caputo, Valentina S, Lichtenberg, Jens, Loaiza, Sandra, Bodine, David M, Karadimitris, Anastasios, Mead, Adam J, Roberts, Irene

“…Recent advances in single-cell techniques have provided the opportunity to finely dissect cellular heterogeneity within populations previously defined by…”
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Ruxolitinib vs best available therapy for ET intolerant or resistant to hydroxycarbamide by Harrison, Claire N., Mead, Adam J., Panchal, Anesh, Fox, Sonia, Yap, Christina, Gbandi, Emmanouela, Houlton, Aimee, Alimam, Samah, Ewing, Joanne, Wood, Marion, Chen, Frederick, Coppell, Jason, Panoskaltsis, Nicki, Knapper, Steven, Ali, Sahra, Hamblin, Angela, Scherber, Robyn, Dueck, Amylou C., Cross, Nicholas C.P., Mesa, Ruben, McMullin, Mary Frances

“…Treatments for high-risk essential thrombocythemia (ET) address thrombocytosis, disease-related symptoms, as well as risks of thrombosis, hemorrhage,…”
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Mass spectrometry imaging of SOD1 protein-metal complexes in SOD1G93A transgenic mice implicates demetalation with pathology by Hale, Oliver J., Wells, Tyler R., Mead, Richard J., Cooper, Helen J.

“…Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of motor neurons in the central nervous system (CNS). Mutations in the metalloenzyme SOD1…”
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Application of single-cell genomics in cancer: promise and challenges by Wills, Quin F, Mead, Adam J

“…Recent advances in single-cell genomics are opening up unprecedented opportunities to transform cancer genomics. While bulk tissue genomic analysis across…”
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Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate by Grover, Amit, Mancini, Elena, Moore, Susan, Mead, Adam J, Atkinson, Deborah, Rasmussen, Kasper D, O'Carroll, Donal, Jacobsen, Sten Eirik W, Nerlov, Claus

“…The erythroid stress cytokine erythropoietin (Epo) supports the development of committed erythroid progenitors, but its ability to act on upstream, multipotent…”
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VALERIE: Visual-based inspection of alternative splicing events at single-cell resolution by Wen, Wei Xiong, Mead, Adam J, Thongjuea, Supat

“…We present VALERIE (Visualising alternative splicing events from single-cell ribonucleic acid-sequencing experiments), an R package for visualising alternative…”
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ADAMTS6: Emerging roles in cardiovascular, musculoskeletal and cancer biology by Mead, Timothy J.

“…ADAMTS family members control mammalian development and disease, primarily through their function as proteases, by regulation of extracellular matrix…”
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Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs by O'Byrne, Sorcha, Elliott, Natalina, Rice, Siobhan, Buck, Gemma, Fordham, Nicholas, Garnett, Catherine, Godfrey, Laura, Crump, Nicholas T., Wright, Gary, Inglott, Sarah, Hua, Peng, Psaila, Bethan, Povinelli, Benjamin, Knapp, David J.H.F., Agraz-Doblas, Antonio, Bueno, Clara, Varela, Ignacio, Bennett, Phillip, Koohy, Hashem, Watt, Suzanne M., Karadimitris, Anastasios, Mead, Adam J., Ancliff, Phillip, Vyas, Paresh, Menendez, Pablo, Milne, Thomas A., Roberts, Irene, Roy, Anindita

“…Human lymphopoiesis is a dynamic lifelong process that starts in utero 6 weeks postconception. Although fetal B-lymphopoiesis remains poorly defined, it is key…”
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Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target by Barber, Siân C., Mead, Richard J., Shaw, Pamela J.

“…The cause(s) of amyotrophic lateral sclerosis (ALS) is not fully understood in the vast majority of cases and the mechanisms involved in motor neuron…”
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Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy by Valori, Chiara F, Ning, Ke, Wyles, Matthew, Mead, Richard J, Grierson, Andrew J, Shaw, Pamela J, Azzouz, Mimoun

“…Spinal muscular atrophy is one of the most common genetic causes of death in childhood, and there is currently no effective treatment. The disease is caused by…”
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