Search Results - "Mead, Graham P."

Use of Nonclonal Serum Immunoglobulin Free Light Chains to Predict Overall Survival in the General Population by Dispenzieri, Angela, MD, Katzmann, Jerry A., PhD, Kyle, Robert A., MD, Larson, Dirk R., MS, Therneau, Terry M., PhD, Colby, Colin L, Clark, Raynell J, Mead, Graham P., BSc, PhD, Kumar, Shaji, MD, Melton, L. Joseph, MD, Rajkumar, S. Vincent, MD

“…Abstract Objective To determine whether the free light chain (FLC) assay provides prognostic information relevant to the general population. Methods After…”
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Quantitative Assessment of Serum and Urinary Polyclonal Free Light Chains in Patients with Chronic Kidney Disease by Hutchison, Colin A, Harding, Stephen, Hewins, Pete, Mead, Graham P, Townsend, John, Bradwell, Arthur R, Cockwell, Paul

“…Monoclonal free light chains (FLC) frequently cause kidney disease in patients with plasma cell dyscrasias. Polyclonal FLC, however, have not been assessed in…”
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Efficient removal of immunoglobulin free light chains by hemodialysis for multiple myeloma : In vitro and in vivo studies by HUTCHISON, Colin A, COCKWELL, Paul, GOEHL, Hermann, STORR, Markus, BRADWELL, Arthur R, REID, Steven, CHANDLER, Katie, MEAD, Graham P, HARRISON, John, HATTERSLEY, John, EVANS, Neil D, CHAPPELL, Mike J, COOK, Mark

“…Of patients with newly diagnosed multiple myeloma, approximately 10% have dialysis-dependent acute renal failure, with cast nephropathy, caused by monoclonal…”
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Assessment of Monoclonal Gammopathies by Nephelometric Measurement of Individual Immunoglobulin κ/λ Ratios by BRADWELL, Arthur R, HARDING, Stephen J, FOURRIER, Nicolas J, WALLIS, Gregg L. F, DRAYSON, Mark T, CARR-SMITH, Hugh D, MEAD, Graham P

“…Currently, monoclonal immunoglobulins are identified and quantified from bands on electrophoretic gels. As an alternative, clonality might be determined by…”
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Serum test for assessment of patients with Bence Jones myeloma by Bradwell, Arthur R, Carr-Smith, Hugh D, Mead, Graham P, Harvey, Timothy C, Drayson, Mark T

“…Bence Jones protein in urine (immunoglobulin free-light-chains) is characteristic of light-chain multiple myeloma. We aimed to compare a quantitative…”
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Highly Sensitive, Automated Immunoassay for Immunoglobulin Free Light Chains in Serum and Urine by Bradwell, Arthur R, Carr-Smith, Hugh D, Mead, Graham P, Tang, Lian X, Showell, Paul J, Drayson, Mark T, Drew, Roger

“…Bence Jones proteins or monoclonal immunoglobulin kappa and lambda free light chains (FLCs) are important markers for identifying and monitoring many patients…”
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Serum free light-chain measurements for identifying and monitoring patients with nonsecretory multiple myeloma by Drayson, Mark, Tang, Lian X., Drew, Roger, Mead, Graham P., Carr-Smith, Hugh, Bradwell, Arthur R.

“…Using sensitive, automated immunoassays, increased concentrations of either κ or λ free light chains (and abnormal κ/λ ratios) were detected in the sera of 19…”
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Overestimation of serum kappa free light chain concentration by immunonephelometry by Mead, Graham P, Carr-Smith, Hugh D

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Frequency of altered monoclonal protein production at relapse of multiple myeloma by Hobbs, Josie A. R., Drayson, Mark T., Sharp, Katie, Harding, Stephen, Bradwell, Arthur R., Mead, Graham P.

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Quantitative assessment of serum and urinary polyclonal free light chains in patients with type II diabetes: an early marker of diabetic kidney disease? by Hutchison, Colin A, Cockwell, Paul, Harding, Steven, Mead, Graham P, Bradwell, Arthur R, Barnett, Anthony H

“…Free light chains (FLCs) are bi-products of normal immunoglobulin synthesis and are predominately removed from the circulation by the kidneys. This study…”
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Reply to “Pediatric reference intervals for immunoglobulin G and its subclasses with Siemens immunonephelometric assays” by Parker, Antony R., Hughes, Richard G., Mead, Graham P., Carr-Smith, Hugh D.

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Serum free light chain immunoassay as an adjunct to serum protein electrophoresis and immunofixation electrophoresis in the detection of multiple myeloma and other B-cell malignancies by Harding, Stephen J, Mead, Graham P, Bradwell, Arthur R, Berard, Annie M

“…Protein and immunofixation electrophoresis of serum and urine are established as diagnostic aids for identifying monoclonal gammopathies. However, many patient…”
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The tumor kinetics of multiple myeloma following autologous stem cell transplantation as assessed by measuring serum-free light chains by Pratt, Guy, Mead, Graham P., Godfrey, Keith R., Hu, Ying, Evans, Neil D., Chappell, Michael J., Lovell, Richard, Bradwell, Arthur R.

“…In multiple myeloma, changes in serum-free immunoglobulin light chains (FLC) are a more rapid indicator of treatment response than intact immunoglobulin due to…”
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Measurement of immunoglobulin free light chains in serum by Mead, Graham P, Drayson, Mark T, Carr-Smith, Hugh D, Bradwell, Arthur R

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Overestimation of Serum [kappa] Free Light Chain Concentration by Immunonephelometry/In Reply by Mead, Graham P, Carr-Smith, Hugh D, Jacobs, Joannes F M, Angelino, Corrie M de Kat, Raymakers, Reinier, Klasen, Ina S

“…All authors confirmed they have contributed to the intellectual content of this paper and have met the following 3 requirements: (a) significant contributions…”
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Assessment of Monoclonal Gammopathies by Nephelometric Measurement of Individual Immunoglobulin {kappa}/{lambda} Ratios by Bradwell, Arthur R, Harding, Stephen J, Fourrier, Nicolas J, Wallis, Gregg L.F, Drayson, Mark T, Carr-Smith, Hugh D, Mead, Graham P

“…Currently, monoclonal immunoglobulins are identified and quantified from bands on electrophoretic gels. As an alternative, clonality might be determined by…”
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Serum free light chains for monitoring multiple myeloma/Response to: Serum free light chains for monitoring multiple myeloma by Tate, J, Mollee, P, Gill, D, Mead, Graham P

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Monoclonal Gammopathy as a Determinant of Adverse Outcomes in Patients with Chronic Kidney Disease by Hutchison, Colin A., Townend, John, Mead, Graham P., Chandler, Katie, Harper, Jo, Bradwell, Arthur R., Zakeri, Rosetta, Cockwell, Paul

“…Elevated serum free light chain (sFLC) concentrations are associated with glomerular and tubulointerstitial disease. We have analyzed a cohort of patients with…”
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Serum free light chains for monitoring multiple myeloma by Tate, J., Mollee, P., Gill, D.

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Serum Free Light Chain (SFLC) Concentration Kinetics in Patients Receiving Bortezomib: Temporary Inhibition of Protein Synthesis and Early Biomarker for Disease Response by Das, Mayukh, Mead, Graham P., Sreekanth, Venkatasampath, Anderson, Julia, Blair, Sue, Howe, Tracy, Cavet, Jim, Liakopoulou, Effie

“…Monoclonal intact immunoglobulin is detectable in the serum of approximately 80% of myeloma patients while SFLC are found to be abnormal in the serum of…”
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