Search Results - "Mešić, Emir"

Navigating the landscape of parameter identifiability methods: A workflow recommendation for model development by Noort, Martijn, Ruppert, Martijn, DeJongh, Joost, Marostica, Eleonora, Bosch, Rolien, Mešić, Emir, Snelder, Nelleke

“…In pharmacometric modeling, it is often important to know whether the data is sufficiently rich to identify the parameters of a proposed model. While it may be…”
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Population pharmacokinetic analysis of rivaroxaban in children and comparison to prospective physiologically‐based pharmacokinetic predictions by Willmann, Stefan, Coboeken, Katrin, Zhang, Yang, Mayer, Hannah, Ince, Ibrahim, Mesic, Emir, Thelen, Kirstin, Kubitza, Dagmar, Lensing, Anthonie W. A., Yang, Haitao, Zhu, Peijuan, Mück, Wolfgang, Drenth, Henk‐Jan, Lippert, Jörg

“…Rivaroxaban has been investigated in the EINSTEIN‐Jr program for the treatment of acute venous thromboembolism (VTE) in children aged 0 to 18 years and in the…”
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Adenoviral vectors expressing siRNAs for discovery and validation of gene function by Arts, Gert-Jan, Langemeijer, Ellen, Tissingh, Rudi, Ma, Libin, Pavliska, Heidi, Dokic, Kristina, Dooijes, Richele, Mesić, Emir, Clasen, Remko, Michiels, Frits, van der Schueren, Jan, Lambrecht, Mark, Herman, Sofie, Brys, Reginald, Thys, Kim, Hoffmann, Marcel, Tomme, Peter, van Es, Helmuth

“…RNA interference is a powerful tool for studying gene function and for drug target discovery in diverse organisms and cell types. In mammalian systems, small…”
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Integrated Population Pharmacokinetics of Daprodustat in Patients with Chronic Kidney Disease with Anemia by Mahar, Kelly M., Yang, Shuying, Mesic, Emir, Post, Teun M., Goulooze, Sebastiaan C.

“…Background and Objective Daprodustat is a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) approved in the USA for treatment of…”
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Finerenone Dose-Exposure-Response for the Primary Kidney Outcome in FIDELIO-DKD Phase III: Population Pharmacokinetic and Time-to-Event Analysis by van den Berg, Paul, Ruppert, Martijn, Mesic, Emir, Snelder, Nelleke, Seelmann, Andreas, Heinig, Roland, Joseph, Amer, Garmann, Dirk, Lippert, Joerg, Eissing, Thomas

“…Background Finerenone is a nonsteroidal selective mineralocorticoid receptor antagonist that recently demonstrated efficacy in delaying chronic kidney disease…”
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An Integrated Population Pharmacokinetic Analysis to Characterize Levonorgestrel Pharmacokinetics After Different Administration Routes by Reinecke, Isabel, Hofmann, Birte, Mesic, Emir, Drenth, Henk‐Jan, Garmann, Dirk

“…To compare the pharmacokinetics (PK) of the progestin levonorgestrel for various routes of administration, an integrated population PK analysis was performed…”
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A cross-species translational pharmacokinetic-pharmacodynamic evaluation of core body temperature reduction by the TRPM8 blocker PF-05105679 by Gosset, James R., Beaumont, Kevin, Matsuura, Tomomi, Winchester, Wendy, Attkins, Neil, Glatt, Sophie, Lightbown, Ian, Ulrich, Kristina, Roberts, Sonia, Harris, Jolie, Mesic, Emir, van Steeg, Tamara, Hijdra, Diana, van der Graaf, Piet H.

“…PF-05105679 is a moderately potent TRPM8 blocker which has been evaluated for the treatment of cold pain sensitivity. The TRPM8 channel is responsible for the…”
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Ein Mehrskalenansatz zur numerischen Simulation und Analyse der metallorganischen Gasphasenepitaxie by Brenner, G., Mukinovic, M., Mesic, E., Schmid, R., Tafipolsky, M., Khanderi, J., Fischer, R. A.

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