Search Results - "Meŕida, I"

Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes by Mazzeo, C, Calvo, V, Alonso, R, Mérida, I, Izquierdo, M

“…Multivesicular bodies (MVBs) are endocytic compartments that enclose intraluminal vesicles (ILVs) formed by inward budding from the limiting membrane of…”
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Relationships between serotonin availability and frontolimbic response to fearful and threatening faces by Janet, R., Costes, N., Mérida, I., Derrington, E., Dreher, J. C.

“…Serotonin is a critical neurotransmitter in the regulation of emotional behavior. Although emotion processing is known to engage a corticolimbic circuit,…”
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NGS and phenotypic ontology-based approaches increase the diagnostic yield in syndromic retinal diseases by Perea-Romero, I., Blanco-Kelly, F., Sanchez-Navarro, I., Lorda-Sanchez, I., Tahsin-Swafiri, S., Avila-Fernandez, A., Martin-Merida, I., Trujillo-Tiebas, M. J., Lopez-Rodriguez, R., Rodriguez de Alba, M., Iancu, I. F., Romero, R., Quinodoz, M., Hakonarson, H., Garcia-Sandova, Blanca, Minguez, P., Corton, M., Rivolta, C., Ayuso, C.

“…Syndromic retinal diseases (SRDs) are a group of complex inherited systemic disorders, with challenging molecular underpinnings and clinical management. Our…”
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SNX27 links DGKζ to the control of transcriptional and metabolic programs in T lymphocytes by Tello-Lafoz, M., Rodríguez-Rodríguez, C., Kinna, G., Loo, L. S., Hong, W., Collins, B. M., Teasdale, R. D., Mérida, I.

“…Sorting nexin 27 (SNX27) recycles PSD-95, Dlg1, ZO-1 (PDZ) domain-interacting membrane proteins and is essential to sustain adequate brain functions. Here we…”
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Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes by Alonso, R, Mazzeo, C, Rodriguez, M C, Marsh, M, Fraile-Ramos, A, Calvo, V, Avila-Flores, A, Merida, I, Izquierdo, M

“…Multivesicular bodies (MVBs) are endocytic compartments that contain intraluminal vesicles formed by inward budding from the limiting membrane of endosomes. In…”
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Five years’ experience of the clinical exome sequencing in a Spanish single center by Arteche-López, A., Ávila-Fernández, A., Riveiro Álvarez, R., Almoguera, B., Bustamante Aragonés, A., Martin-Merida, I., López Martínez, M. A., Giménez Pardo, A., Vélez-Monsalve, C., Gallego Merlo, J., García Vara, I., Blanco-Kelly, F., Tahsin Swafiri, S., Lorda Sánchez, I., Trujillo Tiebas, M. J., Ayuso, C.

“…Nowadays, exome sequencing is a robust and cost-efficient genetic diagnostic tool already implemented in many clinical laboratories. Despite it has undoubtedly…”
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Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1 by Torres-Ayuso, P, Tello-Lafoz, M, Mérida, I, Ávila-Flores, A

“…Diacylglycerol kinases (DGKs) transform diacylglycerol (DAG) into phosphatidic acid (PA), balancing the levels of these key metabolic and signaling lipids. We…”
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Diacylglycerol metabolism attenuates T-cell receptor signaling and alters thymocyte differentiation by Almena, M, Andrada, E, Liebana, R, Merida, I

“…Diacylglycerol (DAG) metabolism has a critical function in Ras-regulated functions in mature T cells, but causal data linking defects in DAG-based signals with…”
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Practical issues and limitations of brain attenuation correction on a simultaneous PET-MR scanner by Mackewn, J. E., Stirling, J., Jeljeli, S., Gould, S-M., Johnstone, R. I., Merida, I., Pike, L. C., McGinnity, C. J., Beck, K., Howes, O., Hammers, A., Marsden, P. K.

“…Background Despite the advent of clinical PET-MR imaging for routine use in 2011 and the development of several methods to address the problem of attenuation…”
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131: Diacylglycerol kinase alpha regulates Src and promotes 3D growth in breast cancer by Torres-Ayuso, P, Daza-Martin, M, Ávila-Flores, A, Mérida, I

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Correction to: Practical issues and limitations of brain attenuation correction on a simultaneous PET-MR scanner by Mackewn, J. E., Stirling, J., Jeljeli, S., Gould, S-M, Johnstone, R. I., Merida, I., Pike, L. C., McGinnity, C. J., Beck, K., Howes, O., Hammers, A., Marsden, P. K.

“…An amendment to this paper has been published and can be accessed via the original article…”
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Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase by Jimenez, Concepción, Jones, David R., Rodríguez-Viciana, Pablo, Gonzalez-García, Ana, Leonardo, Esther, Wennström, Stefan, von Kobbe, Cayetano, Toran, Jose L., R-Borlado, Luis, Calvo, Victor, Copin, Sergio G., Albar, Juan P., Gaspar, M. Luisa, Diez, Emilio, Marcos, Miguel A. R., Downward, Julian, Martinez-A, Carlos, Mérida, Isabel, Carrera, Ana C.

“…p85/p110 phosphoinositide 3‐kinase (PI3K) is a heterodimer composed of a p85‐regulatory and a p110‐catalytic subunit, which is involved in a variety of…”
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Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis by Vicente-Manzanares, M, Rey, M, Jones, D R, Sancho, D, Mellado, M, Rodriguez-Frade, J M, del Pozo, M A, Yáñez-Mó, M, de Ana, A M, Martínez-A, C, Mérida, I, Sánchez-Madrid, F

“…The role of phosphatidylinositol 3-kinase (PI3-kinase), an important enzyme involved in signal transduction events, has been studied in the polarization and…”
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34 Diacylglycerol kinase contribution to mTOR-mediated breast cancer progression by Torres-Ayuso, P, Mérida, I, Ávila-Flores, A

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Changes in the balance between mitogenic and antimitogenic lipid second messengers during proliferation, cell arrest, and apoptosis in T‐lymphocytes by Flores, Ignacio, Jones, David R., Mérida, Isabel

“…ABSTRACT Control of lymphocyte cell survival and proliferation is critical for both the immune response and for the prevention of autoimmune and infectious…”
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The Identification of Phosphatidylinositol 3,5-bisphosphate in T-lymphocytes and Its Regulation by Interleukin-2 by Jones, D R, González-García, A, Díez, E, Martinez-A, C, Carrera, A C, Meŕida, I

“…In recent times 3-phosphoinositides have emerged as important regulators of cell metabolism, survival, and proliferation. During the last year, the…”
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Intermediate Affinity Interleukin-2 Receptor Mediates Survival via a Phosphatidylinositol 3-Kinase-dependent Pathway by González-García, A, Mérida, I, Martinez-A, C, Carrera, A C

“…Peripheral blood T lymphocytes require two signals to enter and progress along the cell cycle from their natural quiescent state. The first activation signal…”
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Conformational Changes Required in the Human Growth Hormone Receptor for Growth Hormone Signaling by Mellado, M, Rodríguez-Frade, J M, Kremer, L, von Kobbe, C, de Ana, A M, Mérida, I, Martinez-A, C

“…Growth hormone (GH) plays a significant role in normal growth and development. Signaling to the cell is believed to require growth hormone receptor (GHR)…”
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Interleukin-2 Causes an Increase in Saturated/Monounsaturated Phosphatidic Acid Derived from 1,2-Diacylglycerol and 1-O-Alkyl-2-acylglycerol by Jones, D R, Pettitt, T R, Sanjuán, M A, Mérida, I, Wakelam, M J

“…Phosphatidic acid generation through activation of diacylglycerol kinase α has been implicated in interleukin-2-dependent T-lymphocyte proliferation. To…”
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Protein tyrosine phosphorylation associated with activation of the interleukin 2 receptor by MERIDA, I, GAULTON, G. N

“…The addition of interleukin 2 (IL2) to the IL2-dependent murine cytotoxic T cell line CTTL-2 induced increased tyrosine phosphorylation of a protein with a…”
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