Search Results - "Mcnamee, Kay"

Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells by Notley, Clare A, Inglis, Julia J, Alzabin, Saba, McCann, Fiona E, McNamee, Kay E, Williams, Richard O

“…IL-17 is implicated in the pathogenesis of rheumatoid arthritis (RA) and has previously been shown to be induced by tumor necrosis factor (TNF) in vitro. The…”
Get full text

Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain by McNamee, Kay E., Burleigh, Annika, Gompels, Luke L., Feldmann, Marc, Allen, Shelley J., Williams, Richard O., Dawbarn, David, Vincent, Tonia L., Inglis, Julia J.

“…The origin of pain in osteoarthritis is poorly understood, but it is generally thought to arise from inflammation within the innervated structures of the…”
Get full text

New developments in the management of psoriasis and psoriatic arthritis: a focus on apremilast by Palfreeman, Andrew C, McNamee, Kay E, McCann, Fiona E

“…Psoriasis is a chronic inflammatory skin disease, most commonly resulting in the occurrence of red and silver scaly plaques. About 30% of psoriasis sufferers…”
Get full text

IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration by McNamee, Kay E., Alzabin, Saba, Hughes, Jane P., Anand, Praveen, Feldmann, Marc, Williams, Richard O., Inglis, Julia J.

“…Interleukin-17 (IL-17) and tumour necrosis factor-α (TNF) are critical in the pathogenesis of arthritis but their relationship during inflammatory pain has…”
Get full text

OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis by Findlay, Emily Gwyer, Danks, Lynett, Madden, Jodie, Cavanagh, Mary M., McNamee, Kay, McCann, Fiona, Snelgrove, Robert J., Shaw, Stevan, Feldmann, Marc, Taylor, Peter Charles, Horwood, Nicole J., Hussell, Tracy

“…An immune response is essential for protection against infection, but, in many individuals, aberrant responses against self tissues cause autoimmune diseases…”
Get full text

Heat shock protein B1-deficient mice display impaired wound healing by Crowe, Jonathan, Aubareda, Anna, McNamee, Kay, Przybycien, Paulina M, Lu, Xin, Williams, Richard O, Bou-Gharios, George, Saklatvala, Jeremy, Dean, Jonathan L E

“…There is large literature describing in vitro experiments on heat shock protein (hsp)B1 but understanding of its function in vivo is limited to studies in mice…”
Get full text

Inhibitor of kappa B epsilon (IκBε) is a non-redundant regulator of c-Rel-dependent gene expression in murine T and B cells by Clark, Joanna M, Aleksiyadis, Karolina, Martin, Alex, McNamee, Kay, Tharmalingam, Tharsana, Williams, Richard O, Mémet, Sylvie, Cope, Andrew P

“…Inhibitors of kappa B (IκBs) -α, -β and -ε effect selective regulation of specific nuclear factor of kappa B (NF-κB) dimers according to cell lineage,…”
Get full text

Animal models of rheumatoid arthritis: How informative are they? by McNamee, Kay, Williams, Richard, Seed, Michael

“…Animal models of arthritis are widely used to de-convolute disease pathways and to identify novel drug targets and therapeutic approaches. However, the high…”
Get full text

TNF receptor 2 signaling prevents DNA methylation at the Foxp3 promoter and prevents pathogenic conversion of regulatory T cells by Tseng, Wen-Yi, Huang, Yi-Shu, Clanchy, Felix, McNamee, Kay, Perocheau, Dany, Ogbechi, Joy, Luo, Shue-Fen, Feldmann, Marc, McCann, Fiona E., Williams, Richard O.

“…Regulatory T (Treg) cells expressing the transcription factor Foxp3 play an important role in maintaining immune homeostasis. Chronic inflammation is…”
Get full text

Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway by Alzabin, Saba, Abraham, Sonya M, Taher, Taher E, Palfreeman, Andrew, Hull, Dobrina, McNamee, Kay, Jawad, Ali, Pathan, Ejaz, Kinderlerer, Anne, Taylor, Peter C, Williams, Richard, Mageed, Rizgar

“…To establish if changes in Th1/Th17 cell populations previously reported in experimental arthritis occur in patients with rheumatoid arthritis (RA) treated…”
Get more information

Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system by Inglis, Julia J., McNamee, Kay E., Chia, Shi‐Lu, Essex, David, Feldmann, Marc, Williams, Richard O., Hunt, Stephen P., Vincent, Tonia

“…Objective OA is the most common joint disease, affecting 10–15% of people over 60 years of age. However, up to 40% of individuals with radiologic damage are…”
Get full text

TNFR signalling and its clinical implications by Tseng, Wen-Yi, Huang, Yi-Shu, Lin, Hsi-Hsien, Luo, Shue-Fen, McCann, Fiona, McNamee, Kay, Clanchy, Felix, Williams, Richard

“…•TNFR1 is ubiquitously expressed, whereas TNFR2 is expressed on a restricted range of cell types.•TNFR1 and TNFR2 signalling mediate different pathophysiologic…”
Get full text

Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis by Huang, Yi-Shu, Tseng, Wen-Yi, Clanchy, Felix I. L., Topping, Louise M., Ogbechi, Joy, McNamee, Kay, Perocheau, Dany, Chiang, Nien-Yi, Ericsson, Peter, Sundstedt, Anette, Xue, Zhong-Tian, Salford, Leif G., Sjögren, Hans-Olov, Stone, Trevor W., Lin, Hsi-Hsien, Luo, Shue-Fen, Williams, Richard O.

“…Chronic inflammatory diseases like rheumatoid arthritis are characterized by a deficit in fully functional regulatory T cells. DNA-methylation inhibitors have…”
Get full text

ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses by Hecht, Iris, Toporik, Amir, Podojil, Joseph R, Vaknin, Ilan, Cojocaru, Gady, Oren, Anat, Aizman, Elizabeta, Liang, Spencer C, Leung, Ling, Dicken, Yosef, Novik, Amit, Marbach-Bar, Nadav, Elmesmari, Aziza, Tange, Clare, Gilmour, Ashley, McIntyre, Donna, Kurowska-Stolarska, Mariola, McNamee, Kay, Leitner, Judith, Greenwald, Shirley, Dassa, Liat, Levine, Zurit, Steinberger, Peter, Williams, Richard O, Miller, Stephen D, McInnes, Iain B, Neria, Eyal, Rotman, Galit

“…The B7-like protein family members play critical immunomodulatory roles and constitute attractive targets for the development of novel therapies for human…”
Get full text

Blockade of NKG2D ameliorates disease in mice with collagen‐induced arthritis: A potential pathogenic role in chronic inflammatory arthritis by Andersson, Anna K., Sumariwalla, Percy F., McCann, Fiona E., Amjadi, Parisa, Chang, Chiwen, McNamee, Kay, Tornehave, Ditte, Haase, Claus, Agersø, Henrik, Stennicke, Vibeke W., Ahern, David, Ursø, Birgitte, Trowsdale, John, Feldmann, Marc, Brennan, Fionula M.

“…Objective To assess the role of the activating receptor NKG2D in arthritis. Methods Levels of NKG2D and its ligands were determined by fluorescence‐activated…”
Get full text

Induction of immune tolerance by CGEN-15001, a novel immunomodulatory Fc fusion protein of the B7 family (THER5P.823) by Hecht, Iris, Vaknin, Ilan, Oren, Anat, Toporik, Amir, Tarcic, Nora, Rotman, Galit, Neria, Eyal, Keren, Aviad, Gilhar, Amos, McNamee, Kay, Williams, Richard, Miller, Stephen, Podojil, Joseph

“…Abstract We discovered a novel immune checkpoint protein based on characteristics of the B7/CD28 family. CGEN-15001 is a fusion protein composed of the…”
Get full text

Inhibitor of Kappa B Epsilon by Clark, Joanna M, Aleksiyadis, Karolina, Martin, Alex, McNamee, Kay, Tharmalingam, Tharsana, Williams, Richard O, Mémet, Sylvie, Cope, Andrew P

“…Inhibitors of kappa B (I[kappa]Bs) -[alpha], -[beta] and -[epsilon] effect selective regulation of specific nuclear factor of kappa B (NF-[kappa]B) dimers…”
Get full text

Treatmentof murine osteoarthritis withTrkAd5 reveals a pivotal rolefor nerve growth factor in non-inflammatory joint pain by McNamee, Kay E., Burleigh, Annika, Gompels, Luke L., Feldmann, Marc, Allen, Shelley J., Williams, Richard O., Dawbarn, David, Vincent, Tonia L., Inglis, Julia J.

“…The origin of pain in osteoarthritis is poorly understood, but it is generally thought to arise from inflammation within the innervated structures of the…”
Get full text

Concurrent Oral 9 – Rheumatoid Arthritis: Aetiopathogenesis [OP59–OP64] by Biliavska, Iuliia V., Bortkevych, Oleg P., Ceeraz, Sabrina, Spencer, Jo, Choy, Ernest H., Corrigall, Valerie, Bombardieri, Michele, Ngar Woon Kam, Yvonne, Brentano, Fabia, Choi, Ken, Kyburz, Diego, Gay, Steffen, McInnes, Iain B., Pitzalis, Costantino, Gompels, Luke L., Vincent, Tonia, Madden, Leigh, Lim, Ngee H., McConnell, Ellen, Mcnamee, Kay, Haskard, Dorian O., Paleolog, Ewa M., Swales, Catherine, Mahoney, David J., Athanasou, Nicholas A., Bombardieri, Michele, Pitzalis, Costantino, Sharif, Omar, Day, Anthony J., Milner, Caroline M., Sabokbar, Afsie, Knowles, Helen, Cleton-Jansen, Anne-Marie, Korsching, Eberhard, Athanasou, Nick

“…Background: Interleukin (IL)-17 is the main Th-1 cytokine, produced by activated T-lymphocytes. The potential IL-17 value in rheumatoid arthritis (RA)…”
Get full text

The role of il-17 in inflammatory hyperalgesia by McNamee, Kay Edwina

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects up to 1% of the population. The importance of tumour necrosis factor (TNF) in RA has…”
Get full text