Search Results - "Mcmullen, Todd P. W."

Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment by Venkatraman, Ganesh, Benesch, Matthew G. K., Tang, Xiaoyun, Dewald, Jay, McMullen, Todd P. W., Brindley, David N.

“…The present work elucidates novel mechanisms for lysophosphatidate (LPA)‐induced chemoresistance using human breast, lung, liver, and thyroid cancer cells. LPA…”
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Tumor‐induced inflammation in mammary adipose tissue stimulates a vicious cycle of autotaxin expression and breast cancer progression by Benesch, Matthew G. K., Tang, Xiaoyun, Dewald, Jay, Dong, Wei‐Feng, Mackey, John R., Hemmings, Denise G., McMullen, Todd P. W., Brindley, David N.

“…ABSTRACT Compared to normal tissues, many cancer cells overexpress autotaxin (ATX). This secreted enzyme produces extracellular lysophosphatidate, which…”
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Hyperparathyroidism in Pregnancy: Options for Localization and Surgical Therapy by McMullen, Todd P. W., Learoyd, Diana L., Williams, David C., Sywak, Mark S., Sidhu, Stan B., Delbridge, Leigh W.

“…Background Hyperparathyroidism in pregnancy is a threat to the health of both mother and fetus. The mothers suffer commonly from nephrolithiasis, hyperemesis,…”
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Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance by Bekele, Raie T., Venkatraman, Ganesh, Liu, Rong-Zong, Tang, Xiaoyun, Mi, Si, Benesch, Matthew G. K., Mackey, John R., Godbout, Roseline, Curtis, Jonathan M., McMullen, Todd P. W., Brindley, David N.

“…Tamoxifen is the accepted therapy for patients with estrogen receptor-α (ERα)-positive breast cancer. However, clinical resistance to tamoxifen, as…”
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Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy by Meng, Guanmin, Tang, Xiaoyun, Yang, Zelei, Benesch, Matthew G. K., Marshall, Alison, Murray, David, Hemmings, Denise G., Wuest, Frank, McMullen, Todd P. W., Brindley, David N.

“…ABSTRACT We have previously established that adipose tissue adjacent to breast tumors becomes inflamed by tumor‐derived cytokines. This stimulates autotaxin…”
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Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice by Benesch, Matthew G. K., Tang, Xiaoyun, Maeda, Tatsuo, Ohhata, Akira, Zhao, Yuan Y., Kok, Bernard P. C., Dewald, Jay, Hitt, Mary, Curtis, Jonathan M., McMullen, Todd P. W., Brindley, David N.

“…ABSTRACT Autotaxin is a secreted enzyme that produces most extracellular lysophosphatidate, which stimulates 6 G‐protein‐coupled receptors. Lysophosphatidate…”
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PDGFRα Enhanced Infection of Breast Cancer Cells with Human Cytomegalovirus but Infection of Fibroblasts Increased Prometastatic Inflammation Involving Lysophosphatidate Signaling by Yang, Zelei, Tang, Xiaoyun, McMullen, Todd P. W., Brindley, David N., Hemmings, Denise G.

“…Human cytomegalovirus (HCMV) infects 40–70% of adults in developed countries. HCMV proteins and DNA are detected in tumors and metastases, suggesting an…”
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Dexamethasone decreases the autotaxin‐lysophosphatidate‐inflammatory axis in adipose tissue: implications for the metabolic syndrome and breast cancer by Meng, Guanmin, Tang, Xiaoyun, Yang, Zelei, Zhao, Yuan Yuan, Curtis, Jonathan M., Mcmullen, Todd P. W., Brindley, David N.

“…ABSTRACT Lysophosphatidate (LPA) signaling through 6 receptors is regulated by the balance of LPA production by autotaxin (ATX) vs. LPA degradation by lipid…”
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Gene expression profile of epithelial-mesenchymal transition mediators in papillary thyroid cancer by Lopez-Campistrous, Ana, Adewuyi, Esther Ekpe, Williams, David C., McMullen, Todd P. W.

“…Purpose Platelet derived growth receptor alpha (PDGFRA) promotes the epithelial-mesenchymal transition (EMT) in thyroid follicular cells and is linked to…”
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Positron Emission Tomography Imaging of Autotaxin in Thyroid and Breast Cancer Models Using [18F]PRIMATX by Litchfield, Marcus, Wuest, Melinda, Glubrecht, Daryl, Briard, Emmanuelle, Auberson, Yves P, McMullen, Todd P. W, Brindley, David N, Wuest, Frank

“…Autotaxin (ATX) is a secreted enzyme responsible for producing lysophosphatidic acid (LPA). The ATX/LPA signaling axis is typically activated in wound healing…”
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Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer by Benesch, Matthew G K, Ko, Yi M, Tang, Xiaoyun, Dewald, Jay, Lopez-Campistrous, Ana, Zhao, Yuan Y, Lai, Raymond, Curtis, Jonathan M, Brindley, David N, McMullen, Todd P W

“…Autotaxin is a secreted enzyme that converts extracellular lysophosphatidylcholine to lysophosphatidate (LPA). In cancers, LPA increases tumour growth,…”
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Molecular imaging of platelet-derived growth factor receptor-alpha (PDGFRα) in papillary thyroid cancer using immuno-PET by Wagner, Michael, Wuest, Melinda, Hamann, Ingrit, Lopez-Campistrous, Ana, McMullen, Todd P.W., Wuest, Frank

“…Receptor tyrosine kinase (RTK) platelet-derived growth factor receptor-alpha (PDGFRα) was recently identified as a molecular switch for dedifferentiation in…”
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Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations by Pelosi, Michele, Testet, Eric, Le Lay, Soazig, Dugail, Isabelle, Tang, Xiaoyun, Mabilleau, Guillaume, Hamel, Yamina, Madrange, Marine, Blanc, Thomas, Odent, Thierry, McMullen, Todd P.W., Alfò, Marco, Brindley, David N., de Lonlay, Pascale

“…Lipin-1 is a Mg2+-dependent phosphatidic acid phosphatase (PAP) that in mice is necessary for normal glycerolipid biosynthesis, controlling adipocyte…”
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Coming of Age for Autotaxin and Lysophosphatidate Signaling: Clinical Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation by Benesch, Matthew G K, MacIntyre, Iain T K, McMullen, Todd P W, Brindley, David N

“…A quarter-century after the discovery of autotaxin in cell culture, the autotaxin-lysophosphatidate (LPA)-lipid phosphate phosphatase axis is now a promising…”
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The Wnt/ β -catenin pathway drives increased cyclin D1 levels in lymph node metastasis in papillary thyroid cancer by Zhang, Jingdong, MD, Gill, Anthony J.M., MD, Issacs, Joseph D., MD, Atmore, Bryn, MD, Johns, Amber, MD, Delbridge, Leigh W., MD, Lai, Raymond, MD, PhD, McMullen, Todd P.W., MD, PhD

“…Summary We examined the expression of cyclin D1 in conjunction with β -catenin and the phosphorylated inactive form of glycogen synthase kinase 3β (GSK-3 β )…”
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Autocrine activation of platelet-derived growth factor receptor α in metastatic papillary thyroid cancer by Adewuyi, Esther Ekpe, Deschenes, Jean, Lopez-Campistrous, Ana, Kattar, Mireille M., Ghosh, Sunita, McMullen, Todd P.W.

“…Metastatic dissemination of papillary thyroid cancer has been reported to be strongly associated with expression of platelet-derived growth factor (PDGFR) α…”
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Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice[S] by Tang, Xiaoyun, Benesch, Matthew G.K., Dewald, Jay, Zhao, Yuan Y., Patwardhan, Neeraj, Santos, Webster L., Curtis, Jonathan M., McMullen, Todd P.W., Brindley, David N.

“…Lipid phosphate phosphatase-1 (LPP1) degrades lysophosphatidate (LPA) and attenuates receptor-mediated signaling. LPP1 expression is low in many cancer cells…”
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Dexamethasone Attenuates X-Ray-Induced Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle in Breast Tissue and Subsequent Breast Fibrosis by Meng, Guanmin, Wuest, Melinda, Tang, Xiaoyun, Dufour, Jennifer, McMullen, Todd P W, Wuest, Frank, Murray, David, Brindley, David N

“…We recently showed that radiation-induced DNA damage in breast adipose tissue increases autotaxin secretion, production of lysophosphatidate (LPA) and…”
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The utility of thyroid ultrasonography in the management of thyroid nodules by Gamme, Gary, MD, Williams, David C., MD, McMullen, Todd P.W., MD, PhD, Wiebe, Edward, MD, Ghosh, Sunita, PhD, Litt, Brendan, MD, Parrington, Tyler, MD

“…Background Ultrasonography for thyroid nodules is one of the most common imaging tests performed in the general population. Details from ultrasound reports…”
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FOXQ1 is Differentially Expressed Across Breast Cancer Subtypes with Low Expression Associated with Poor Overall Survival by Elian, Fahed A, Are, Ubah, Ghosh, Sunita, Nuin, Paulo, Footz, Tim, McMullen, Todd P W, Brindley, David N, Walter, Michael A

“…Forkhead box Q1 ( ) has been shown to contribute to the development and progression of cancers, including ovarian and breast cancer (BC). However, research…”
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