Search Results - "Mcmillan, D. C."

Cancer and systemic inflammation: treat the tumour and treat the host by Roxburgh, C S D, McMillan, D C

“…Determinants of cancer progression and survival are multifactorial and host responses are increasingly appreciated to have a major role. Indeed, the…”
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A derived neutrophil to lymphocyte ratio predicts survival in patients with cancer by Proctor, M J, McMillan, D C, Morrison, D S, Fletcher, C D, Horgan, P G, Clarke, S J

“…Background: The neutrophil lymphocyte ratio (NLR) has prognostic value in patients with a variety of cancers. Many chemotherapeutic trial databases hold…”
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Impact of anastomotic leakage on long-term survival of patients undergoing curative resection for colorectal cancer by McArdle, C. S., McMillan, D. C., Hole, D. J.

“…Background: The impact of anastomotic leakage on immediate postoperative mortality in patients undergoing potentially curative resection for colorectal cancer…”
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An inflammation-based prognostic score (mGPS) predicts cancer survival independent of tumour site: a Glasgow Inflammation Outcome Study by Proctor, M J, Morrison, D S, Talwar, D, Balmer, S M, O'Reilly, D S J, Foulis, A K, Horgan, P G, McMillan, D C

“…Introduction: A selective combination of C-reactive protein and albumin (termed the modified Glasgow Prognostic Score, mGPS) has been shown to have prognostic…”
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The relationship between tumour stroma percentage, the tumour microenvironment and survival in patients with primary operable colorectal cancer by Park, J.H., Richards, C.H., McMillan, D.C., Horgan, P.G., Roxburgh, C.S.D.

“…Tumour stroma percentage (TSP) has previously been reported to predict survival in patients with colorectal cancer (CRC); however, whether this is independent…”
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Comparison of the prognostic value of longitudinal measurements of systemic inflammation in patients undergoing curative resection of colorectal cancer by Guthrie, G J K, Roxburgh, C S D, Farhan-Alanie, O M, Horgan, P G, McMillan, D C

“…Background: The systemic inflammation-based prognostic scores, modified Glasgow Prognostic Score (mGPS) and the neutrophil-lymphocyte ratio (NLR) are now…”
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The relationship between lymphocyte subsets and clinico-pathological determinants of survival in patients with primary operable invasive ductal breast cancer by Mohammed, Z M A, Going, J J, Edwards, J, Elsberger, B, McMillan, D C

“…Background: The importance of lymphocyte subtypes in determining outcome in primary operable ductal invasive breast cancer remains unclear. The aim of present…”
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The relationship between pre-operative psoas and skeletal muscle parameters and survival following endovascular aneurysm repair: a systematic review and meta-analysis by Bradley, N. A., Roxburgh, C. S. D., McMillan, D. C., Guthrie, G. J. K.

“…Sarcopenia is characterised by chronically reduced skeletal muscle volume and function, and is determined radiologically by psoas and skeletal muscle…”
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Systemic inflammatory response predicts survival following curative resection of colorectal cancer by McMillan, D. C., Canna, K., McArdle, C. S.

“…Background: Some studies have shown that the presence of a systemic inflammatory response, as evidenced by raised circulating concentrations of C‐reactive…”
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The relationship between the presence and site of cancer, an inflammation-based prognostic score and biochemical parameters. Initial results of the Glasgow Inflammation Outcome Study by Proctor, M J, Talwar, D, Balmar, S M, O'Reilly, D S J, Foulis, A K, Horgan, P G, Morrison, D S, McMillan, D C

“…Background: Cancer incidence is increasing in the United Kingdom, as well as on a global basis. Biochemical parameters, such as C-reactive protein and albumin…”
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The relationship between components of tumour inflammatory cell infiltrate and clinicopathological factors and survival in patients with primary operable invasive ductal breast cancer by Mohammed, Z MA, Going, J J, Edwards, J, Elsberger, B, Doughty, J C, McMillan, D C

“…Background: The importance of the components of host local inflammatory response in determining outcome in primary operable ductal invasive breast cancer is…”
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The relationship between the tumour stroma percentage, clinicopathological characteristics and outcome in patients with operable ductal breast cancer by Gujam, F J A, Edwards, J, Mohammed, Z M A, Going, J J, McMillan, D C

“…Background: The percentage of tumour stroma (TSP) has recently been reported to be a novel independent predictor of outcome in patients with a variety of…”
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Preoperative systemic inflammation predicts postoperative infectious complications in patients undergoing curative resection for colorectal cancer by Moyes, L H, Leitch, E F, McKee, R F, Anderson, J H, Horgan, P G, McMillan, D C

“…The presence of systemic inflammation before surgery, as evidenced by the glasgow prognostic score (mGPS), predicts poor long-term survival in colorectal…”
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Serum amylase and C-reactive protein in risk stratification of pancreas-specific complications after pancreaticoduodenectomy by Palani Velu, L. K., McKay, C. J., Carter, C. R., McMillan, D. C., Jamieson, N. B., Dickson, E. J.

“…Background Pancreas‐specific complications (PSCs), comprising postoperative pancreatic fistula, haemorrhage and intra‐abdominal collections, are drivers of…”
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Comparison of the prognostic value of selected markers of the systemic inflammatory response in patients with colorectal cancer by LEITCH, E. F, CHAKRABARTI, M, CROZIER, J. E. M, MCKEE, R. F, ANDERSON, J. H, HORGAN, P. G, MCMILLAN, D. C

“…There is increasing evidence that the presence of a systemic inflammatory response plays an important role in predicting survival in patients with colorectal…”
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Evaluation of an inflammation-based prognostic score in patients with inoperable gastro-oesophageal cancer by CRUMLEY, A. B. C, MCMILLAN, D. C, MCKERNAN, M, MCDONALD, A. C, STUART, R. C

“…There is increasing evidence that the presence of an ongoing systemic inflammatory response is associated with poor outcome in patients with advanced cancer…”
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Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer by FORREST, L. M, MCMILLAN, D. C, MCARDLE, C. S, ANGERSON, W. J, DUNLOP, D. J

“…A score based on the combination of the systemic inflammatory response and albumin hazards ratio (HR) 1.70, 95% CI 1.23 - 2.35, P=0.001) was comparable in…”
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Use of Inflammatory Markers to Guide Cancer Treatment by Clarke, S J, Chua, W, Moore, M, Kao, S, Phan, V, Tan, C, Charles, K, McMillan, D C

“…Patient‐related factors, especially markers of inflammatory response, are prognostic in many common solid cancers. Here we review how such markers, in…”
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Circulating IL-6 concentrations link tumour necrosis and systemic and local inflammatory responses in patients undergoing resection for colorectal cancer by Guthrie, G J K, Roxburgh, C S D, Richards, C H, Horgan, P G, McMillan, D C

“…Background: Cancer-associated inflammation, in the form of local and systemic inflammatory responses, appear to be linked to tumour necrosis and have…”
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The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer by Alexander, P. G., van Wyk, H. C., Pennel, K. A. F., Hay, J., McMillan, D. C., Horgan, P. G., Roxburgh, C. S. D., Edwards, J., Park, J. H.

“…Background Glasgow Microenvironment Score (GMS) stratifies long-term survival into three groups based on tumour phenotype: peritumoural inflammation…”
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