Search Results - "Mcmahon, C"

TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins by McMahon, Aoife C., Rahman, Reazur, Jin, Hua, Shen, James L., Fieldsend, Allegra, Luo, Weifei, Rosbash, Michael

“…RNA transcripts are bound and regulated by RNA-binding proteins (RBPs). Current methods for identifying in vivo targets of an RBP are imperfect and…”
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Erectile dysfunction by McMahon, C. G.

“…In the past 30 years, advances in basic science have been instrumental in the evolution of the male sexual health treatment paradigm from a psychosexual model…”
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Characterization of Reproductive, Metabolic, and Endocrine Features of Polycystic Ovary Syndrome in Female Hyperandrogenic Mouse Models by Caldwell, A. S. L, Middleton, L. J, Jimenez, M, Desai, R, McMahon, A. C, Allan, C. M, Handelsman, D. J, Walters, K. A

“…Polycystic ovary syndrome (PCOS) affects 5–10% of women of reproductive age, causing a range of reproductive, metabolic and endocrine defects including…”
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Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework by Solon-Biet, Samantha M., Cogger, Victoria C., Pulpitel, Tamara, Heblinski, Marika, Wahl, Devin, McMahon, Aisling C., Warren, Alessandra, Durrant-Whyte, Jessica, Walters, Kirsty A., Krycer, James R., Ponton, Fleur, Gokarn, Rahul, Wali, Jibran A., Ruohonen, Kari, Conigrave, Arthur D., James, David E., Raubenheimer, David, Morrison, Christopher D., Le Couteur, David G., Simpson, Stephen J.

“…Fibroblast growth factor 21 (FGF21) is the first known endocrine signal activated by protein restriction. Although FGF21 is robustly elevated in low-protein…”
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Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays by Harris, Kate, Aylott, Mike, Cui, Yi, Louttit, James B, McMahon, Nicholas C, Sridhar, Arun

“…Human-induced pluripotent stem cell cardiomyocytes (hiPSC-CMs) are a potential source to develop assays for predictive electrophysiological safety screening…”
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A standardized framework for representation of ancestry data in genomics studies, with application to the NHGRI-EBI GWAS Catalog by Morales, Joannella, Welter, Danielle, Bowler, Emily H, Cerezo, Maria, Harris, Laura W, McMahon, Aoife C, Hall, Peggy, Junkins, Heather A, Milano, Annalisa, Hastings, Emma, Malangone, Cinzia, Buniello, Annalisa, Burdett, Tony, Flicek, Paul, Parkinson, Helen, Cunningham, Fiona, Hindorff, Lucia A, MacArthur, Jacqueline A L

“…The accurate description of ancestry is essential to interpret, access, and integrate human genomics data, and to ensure that these benefit individuals from…”
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The suppression of Antarctic bottom water formation by melting ice shelves in Prydz Bay by Williams, G. D., Herraiz-Borreguero, L., Roquet, F., Tamura, T., Ohshima, K. I., Fukamachi, Y., Fraser, A. D., Gao, L., Chen, H., McMahon, C. R., Harcourt, R., Hindell, M.

“…A fourth production region for the globally important Antarctic bottom water has been attributed to dense shelf water formation in the Cape Darnley Polynya,…”
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The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice by Solon-Biet, Samantha M., McMahon, Aisling C., Ballard, J. William O., Ruohonen, Kari, Wu, Lindsay E., Cogger, Victoria C., Warren, Alessandra, Huang, Xin, Pichaud, Nicolas, Melvin, Richard G., Gokarn, Rahul, Khalil, Mamdouh, Turner, Nigel, Cooney, Gregory J., Sinclair, David A., Raubenheimer, David, Le Couteur, David G., Simpson, Stephen J.

“…The fundamental questions of what represents a macronutritionally balanced diet and how this maintains health and longevity remain unanswered. Here, the…”
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Inappropriate prescribing in older fallers presenting to an Irish emergency department by McMahon, C Geraldine, Cahir, Caitriona A, Kenny, Rose Anne, Bennett, Kathleen

“…certain medications increase falls risk in older people. to assess if prescribing modification occurs in older falls presenting to an emergency department…”
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Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice by Solon-Biet, Samantha M., Mitchell, Sarah J., Coogan, Sean C.P., Cogger, Victoria C., Gokarn, Rahul, McMahon, Aisling C., Raubenheimer, David, de Cabo, Rafael, Simpson, Stephen J., Le Couteur, David G.

“…Both caloric restriction (CR) and low-protein, high-carbohydrate (LPHC) ad-libitum-fed diets increase lifespan and improve metabolic parameters such as…”
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Movement responses to environment: fast inference of variation among southern elephant seals with a mixed effects model by Jonsen, I. D., McMahon, C. R., Patterson, T. A., Auger-Méthé, M., Harcourt, R., Hindell, M. A., Bestley, S.

“…Like many species, movement patterns of southern elephant seals (Mirounga leonina) are being influenced by long-term environmental change. These seals migrate…”
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Macronutrient balance, reproductive function, and lifespan in aging mice by Solon-Biet, Samantha M., Walters, Kirsty A., Simanainen, Ulla K., McMahon, Aisling C., Ruohonen, Kari, Ballard, John William O., Raubenheimer, David, Handelsman, David J., Le Couteur, David G., Simpson, Stephen J.

“…Significance A fundamental tenet of life-history theory is that reproduction and longevity trade off against one another. Experiments on invertebrates show…”
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Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk by Mirams, Gary R., Cui, Yi, Sher, Anna, Fink, Martin, Cooper, Jonathan, Heath, Bronagh M., McMahon, Nick C., Gavaghan, David J., Noble, Denis

“…Aims The level of inhibition of the human Ether-à-go-go-related gene (hERG) channel is one of the earliest preclinical markers used to predict the risk of a…”
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Modelled mid‐trophic pelagic prey fields improve understanding of marine predator foraging behaviour by Green, D. B., Bestley, S., Trebilco, R., Corney, S. P., Lehodey, P., McMahon, C. R., Guinet, C., Hindell, Mark A.

“…Biophysical interactions are influential in determining the scale of key ecological processes within marine ecosystems. For oceanic predators, this means…”
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The importance of sample size in marine megafauna tagging studies by Sequeira, A. M. M., Heupel, M. R., Lea, M.-A., Eguíluz, V. M., Duarte, M., Meekan, M. G., Thums, M., Calich, H. J., Carmichael, R. H., Costa, D. P., Ferreira, L. C., Fernandéz-Gracia, J., Harcourt, R., Harrison, A.-L., Jonsen, I., McMahon, C. R., Sims, D. W., Wilson, R. P., Hays, G. C.

“…Telemetry is a key, widely used tool to understand marine megafauna distribution, habitat use, behavior, and physiology; however, a critical question remains:…”
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What do women undergoing in vitro fertilization (IVF) understand about their chance of IVF success? by McMahon, C, Hammarberg, K, Lensen, S, Wang, R, Mol, B W, Vollenhoven, B J N

“…How well informed are Australian women who undergo IVF about their chances of having a baby? Only one in four women estimated their individual chance of…”
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Using short-term measures of behaviour to estimate long-term fitness of southern elephant seals by New, L. F., Clark, J. S., Costa, D. P., Fleishman, E., Hindell, M. A., Klanjšček, T., Lusseau, D., Kraus, S., McMahon, C. R., Robinson, P. W., Schick, R. S., Schwarz, L. K., Simmons, S. E., Thomas, L., Tyack, P., Harwood, J.

“…Environmental changes (a type of disturbance) are altering the habitat of southern elephant seals Mirounga leonina, an apex marine predator in the Southern…”
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Age at first birth, mode of conception and psychological wellbeing in pregnancy: findings from the parental age and transition to parenthood Australia (PATPA) study by McMahon, C.A., Boivin, J., Gibson, F.L., Hammarberg, K., Wynter, K., Saunders, D., Fisher, J.

“…BACKGROUND It is increasingly common for women in high-income countries to delay childbearing. We aimed to describe the context of pregnancy for first-time…”
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Antarctic Futures: An Assessment of Climate-Driven Changes in Ecosystem Structure, Function, and Service Provisioning in the Southern Ocean by Rogers, A.D, Frinault, B.A.V, Barnes, D.K.A, Bindoff, N.L, Downie, R, Ducklow, H.W, Friedlaender, A.S, Hart, T, Hill, S.L, Hofmann, E.E, Linse, K, McMahon, C.R, Murphy, E.J, Pakhomov, E.A, Reygondeau, G, Staniland, I.J, Wolf-Gladrow, D.A, Wright, R.M

“…In this article, we analyze the impacts of climate change on Antarctic marine ecosystems. Observations demonstrate large-scale changes in the physical…”
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Elucidation of the Concise Biosynthetic Pathway of the Communesin Indole Alkaloids by Lin, Hsiao-Ching, Chiou, Grace, Chooi, Yit-Heng, McMahon, Travis C., Xu, Wei, Garg, Neil K., Tang, Yi

“…The communesins are a prominent class of indole alkaloids isolated from Penicillium species. Owing to their daunting structural framework and potential as…”
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