Search Results - "Mcleod, Robbie L"

Treatment of acute lung injury by targeting MG53-mediated cell membrane repair by Jia, Yanlin, Chen, Ken, Lin, Peihui, Lieber, Gissela, Nishi, Miyuki, Yan, Rosalie, Wang, Zhen, Yao, Yonggang, Li, Yu, Whitson, Bryan A., Duann, Pu, Li, Haichang, Zhou, Xinyu, Zhu, Hua, Takeshima, Hiroshi, Hunter, John C., McLeod, Robbie L., Weisleder, Noah, Zeng, Chunyu, Ma, Jianjie

“…Injury to lung epithelial cells has a role in multiple lung diseases. We previously identified mitsugumin 53 (MG53) as a component of the cell membrane repair…”
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Mineralocorticoid receptor antagonists attenuate pulmonary inflammation and bleomycin-evoked fibrosis in rodent models by Lieber, Gissela B, Fernandez, Xiomara, Mingo, Garfield G, Jia, Yanlin, Caniga, Michael, Gil, Malgorzata A., Keshwani, Shanil, Woodhouse, Janice D., Cicmil, Milenko, Moy, Lily Y, Kelly, Nancy, Jimenez, Johanna, Crawley, Yvette, Anthes, John C, Klappenbach, Joel, Ma, Yu-Lu, McLeod, Robbie L.

“…Accumulating evidence indicates protective actions of mineralocorticoid antagonists (MR antagonists) on cardiovascular pathology, which includes blunting…”
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Preclinical Experimental and Mathematical Approaches for Assessing Effective Doses of Inhaled Drugs, Using Mometasone to Support Human Dose Predictions by Caniga, Michael, Cabal, Antonio, Mehta, Khamir, Ross, David S, Gil, Malgorzata A, Woodhouse, Janice D, Eckman, Joseph, Naber, John R, Callahan, Marissa K, Goncalves, Luciano, Hill, Susan E, Mcleod, Robbie L, McIntosh, Fraser, Freke, Mark C, Visser, Sandra A G, Johnson, Neil, Salmon, Michael, Cicmil, Milenko

“…Understanding the relationship between dose, lung exposure, and drug efficacy continues to be a challenging aspect of inhaled drug development. An experimental…”
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Efficacy of a NOP1 Agonist (SCH486757) in Subacute Cough by Woodcock, Ashley, McLeod, Robbie L, Sadeh, Jonathan, Smith, Jaclyn A

“…Currently, opiates are widely used as antitussives but have substantial side effects. Recently, it has been proposed that NOP1 receptor agonists may be useful…”
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Pharmacological evaluation of selective α2c-adrenergic agonists in experimental animal models of nasal congestion by Jia, Yanlin, Mingo, Garfield G, Hunter, John C, Lieber, Gissela B, Palamanda, Jairam R, Mei, Hong, Boyce, Christopher W, Koss, Michael C, Yu, Yongxin, Cicmil, Milenko, Hey, John A, McLeod, Robbie L

“…Nasal congestion is one of the most troublesome symptoms of many upper airways diseases. We characterized the effect of selective α2c-adrenergic agonists in…”
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Discovery of Orally Active 3-Pyridinyl-tropane As a Potent Nociceptin Receptor Agonist for the Management of Cough by Yang, Shu-Wei, Ho, Ginny, Tulshian, Deen, Greenlee, William J, Anthes, John, Fernandez, Xiomara, McLeod, Robbie L, Hey, John A, Xu, Xiaoying

“…A series of 3-pyridinyl-tropane analogues based on previously reported compound 1 have been synthesized and shown to bind to the nociceptin receptor with high…”
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Anandamide induces cough in conscious guinea‐pigs through VR1 receptors by Jia, Yanlin, McLeod, Robbie L, Wang, Xin, Parra, Leonard E, Egan, Robert W, Hey, John A

“…Endogenous neuronal lipid mediator anandamide, which can be synthesized in the lung, is a ligand of both cannabinoid (CB) and vanilloid receptors (VR). The…”
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The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety by Ho, Ginny D., Anthes, John, Bercovici, Ana, Caldwell, John P., Cheng, Kuo-Chi, Cui, Xiaoming, Fawzi, Ahmad, Fernandez, Xiomara, Greenlee, William J., Hey, John, Korfmacher, Walter, Lu, Sherry X., McLeod, Robbie L., Ng, Fay, Torhan, April Smith, Tan, Zheng, Tulshian, Deen, Varty, Geoffrey B., Xu, Xiaoying, Zhang, Hongtao

“…The discovery of 1 as a high-affinity ligand for the nociceptin receptor has led to the synthesis of a series of tropane (8-methyl-8-azabicyclo[3.2.1]octane)…”
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Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators by Methot, Joey L, Zhou, Hua, McGowan, Meredeth A, Anthony, Neville John, Christopher, Matthew, Garcia, Yudith, Achab, Abdelghani, Lipford, Kathryn, Trotter, Benjamin Wesley, Altman, Michael D, Fradera, Xavier, Lesburg, Charles A, Li, Chaomin, Alves, Stephen, Chappell, Craig P, Jain, Renu, Mangado, Ruban, Pinheiro, Elaine, Williams, Sybill M. G, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vincent, McLeod, Robbie L, Lee, Hyun-Hee, Yu, Hongshi, Shah, Sanjiv, Katz, Jason D

“…The approvals of idelalisib and duvelisib have validated PI3Kδ inhibitors for the treatment for hematological malignancies driven by the PI3K/AKT pathway. Our…”
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Effect of combined histamine H1 and H3 receptor blockade on cutaneous microvascular permeability elicited by compound 48/80 by McLeod, Robbie L, Mingo, Garfield G, Kreutner, William, Hey, John A

“…The pharmacological consequences of combining a histamine H1 receptor antagonist with a H3 antagonist on cutaneous microvascular permeability due to…”
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Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability by Methot, Joey L, Zhou, Hua, Kattar, Sam D, McGowan, Meredeth A, Wilson, Kevin, Garcia, Yudith, Deng, Yongi, Altman, Michael, Fradera, Xavier, Lesburg, Charles, Fischmann, Thierry, Li, Chaomin, Alves, Steve, Shah, Sanjiv, Fernandez, Rafael, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vince, McLeod, Robbie L, Yu, Hongshi, Bass, Alan, Kemper, Ray, Gatto, Nicholas T, LaFranco-Scheuch, Lisa, Trotter, Benjamin Wesley, Guzi, Timothy, Katz, Jason D

“…PI3Kδ catalytic activity is required for immune cell activation, and has been implicated in inflammatory diseases as well as hematological malignancies in…”
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Characterizing Pharmacokinetic-Pharmacodynamic Relationships and Efficacy of PI3K δ Inhibitors in Respiratory Models of TH2 and TH1 Inflammation by McLeod, Robbie L, Gil, Malgorzata A, Chen, Dapeng, Cabal, Antonio, Katz, Jason, Methot, Joey, Woodhouse, Janice D, Dorosh, Lauren, Geda, Prasanthi, Mehta, Khamir, Cicmil, Milenko, Baltus, Gretchen A, Bass, Alan, Houshyar, Hani, Caniga, Michael, Yu, Hongshi, Gervais, Francois, Alves, Stephen, Shah, Sanjiv

“…We leveraged a clinical pharmacokinetic (PK)/pharmacodynamics (PD)/efficacy relationship established with an oral phosphatidylinositol 3-kinase (PI3K)…”
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Alpha-2c-adrenergic receptors contribute to basal nasal patency in the anesthetized cat by Mingo, Garfield G, Corboz, Michel R, Salisbury, Brian G, McCormick, Kevin D, Boyce, Christopher W, Mukhopadhyay, Gitali, McLeod, Robbie L

“…Nasal congestion is the most troublesome symptom associated with a variety of upper airway diseases, including allergic rhinitis and the common cold. A better…”
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Characterization of murine CEACAM1 in vivo reveals low expression on CD8 + T cells and no tumor growth modulating activity by anti-CEACAM1 mAb CC1 by McLeod, Robbie L, Angagaw, Minilik H, Baral, Toya Nath, Liu, Liming, Moniz, Raymond Joseph, Laskey, Jason, Hsieh, SuChun, Lee, Mike, Han, Jin-Hwan, Issafras, Hassan, Javaid, Sarah, Loboda, Andrey, Sadekova, Svetlana, O'Connor, Joann A, Tse, Archie, Punnonen, Juha

“…Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) has been reported to mediate both tumorigenic and anti-tumor effects . Blockade of the…”
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Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary inflammation by Gil, Malgorzata A., Caniga, Michael, Woodhouse, Janice D., Eckman, Joseph, Lee, Hyun-Hee, Salmon, Michael, Naber, John, Hamilton, Valerie T., Sevilla, Raquel S., Bettano, Kimberly, Klappenbach, Joel, Moy, Lily, Correll, Craig C., Gervais, Francois G., Siliphaivanh, Phieng, Zhang, Weisheng, Zhang-Hoover, Jie, McLeod, Robbie L., Cicmil, Milenko

“…Alternaria alternata is a fungal allergen linked to the development of severe asthma in humans. In view of the clinical relationship between A. alternata and…”
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Etanercept ameliorates inflammation and pain in a novel mono-arthritic multi-flare model of streptococcal cell wall induced arthritis by Chakravarthy, Kalyan, Faltus, Robert, Robinson, Gain, Sevilla, Raquel, Shin, John, Zielstorff, Mark, Byford, Alan, Leccese, Erica, Caniga, Michael J, Hseih, SuChun, Zhang, Shuli, Chiu, Chi-Sung, Zhang-Hoover, Jie, Moy, Lily Y, McLeod, Robbie L, Stoffregen, Dana, Zhang, Weisheng, Murtaza, Anwar, Cicmil, Milenko

“…The impact of anti-TNF, corticosteroid and analgesic therapy on inflammation and pain was evaluated in a novel mono-arthritic multi-flare rat Streptococcal…”
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TRPV1 Antagonists as Potential Antitussive Agents by McLeod, Robbie L., Correll, Craig C., Jia, Yanlin, Anthes, John C.

“…Cough is an important defensive pulmonary reflex that removes irritants, fluids, or foreign materials from the airways. However, when cough is exceptionally…”
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Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models by McLeod, Robbie L., Tulshian, Deen B., Bolser, Donald C., Varty, Geoffrey B., Baptista, Marco, Fernandez, Xiomara, Parra, Leonard E., Zimmer, Jennifer C., Erickson, Christine H., Ho, Ginny D., Jia, Yanlin, Ng, Fay W., Korfmacher, Walter, Xu, Xiaoying, Veals, John, Smith-Torhan, April, Wainhaus, Samuel, Fawzi, Ahmad B., Austin, Theodore M., van Heek, Margaret, Hey, John A.

“…We describe the pharmacological and pharmacokinetic profiles of SCH 486757, a nociceptin/orphanin FQ peptide (NOP) receptor agonist that has recently entered…”
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Where are the new cough treatments: a debriefing of recent clinical proof-of-concept trials with the NOP agonist SCH 486757 by McLeod, Robbie L, Tulshian, Deen B, Sadeh, Jonathan

“…Cough continues to be one of the top reasons why patients seek medical attention from health care providers. The prescription antitussive market is dominated…”
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In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461 by Van Heek, M, France, C F, Compton, D S, McLeod, R L, Yumibe, N P, Alton, K B, Sybertz, E J, Davis, Jr, H R

“…SCH48461 is a selective and highly potent inhibitor of cholesterol absorption. In rats, SCH48461 is rapidly and completely metabolized in the first pass…”
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