Search Results - "Mclennan, Alexander G"

Substrate ambiguity among the nudix hydrolases: biologically significant, evolutionary remnant, or both? by McLennan, Alexander G

“…Many members of the nudix hydrolase family exhibit considerable substrate multispecificity and ambiguity, which raises significant issues when assessing their…”
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Seafood label quality and mislabelling rates hamper consumer choices for sustainability in Australia by Cundy, Megan E., Santana-Garcon, Julia, McLennan, Alexander G., Ayad, Marcelle E., Bayer, Philipp E., Cooper, Madalyn, Corrigan, Shannon, Harrison, Emily, Wilcox, Chris

“…Seafood mislabelling and species substitution, compounded by a convoluted seafood supply chain with significant traceability challenges, hinder efforts towards…”
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NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes by Marriott, Andrew S, Vasieva, Olga, Fang, Yongxiang, Copeland, Nikki A, McLennan, Alexander G, Jones, Nigel J

“…Regulation of gene expression is one of several roles proposed for the stress-induced nucleotide diadenosine tetraphosphate (Ap4A). We have examined this…”
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Re-evaluation of Diadenosine Tetraphosphate (Ap4A) From a Stress Metabolite to Bona Fide Secondary Messenger by Ferguson, Freya, McLennan, Alexander G., Urbaniak, Michael D., Jones, Nigel J., Copeland, Nikki A.

“…Cellular homeostasis requires adaption to environmental stress. In response to various environmental and genotoxic stresses, all cells produce dinucleoside…”
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Ametabolic embryos of Artemia franciscana accumulate DNA damage during prolonged anoxia by McLennan, Alexander G

“…Encysted embryos of the brine shrimp Artemia franciscana are able to survive prolonged periods of anoxia even when fully hydrated. During this time there is no…”
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The complex enzymology of mRNA decapping: Enzymes of four classes cleave pyrophosphate bonds by Kramer, Susanne, McLennan, Alexander G.

“…The 5′ ends of most RNAs are chemically modified to enable protection from nucleases. In bacteria, this is often achieved by keeping the triphosphate terminus…”
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Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein by Abdelraheim, Salama R, Spiller, David G, McLennan, Alexander G

“…The human NUDT12 Nudix hydrolase has been expressed in insect cells from a baculovirus vector as a His-tagged recombinant protein. In vitro, it efficiently…”
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Regulation of Dinucleoside Polyphosphate Pools by the YgdP and ApaH Hydrolases Is Essential for the Ability of Salmonella enterica serovar Typhimurium to Invade Cultured Mammalian Cells by Ismail, Thamir M., Hart, C.Anthony, McLennan, Alexander G.

“…The ygdP and apaH genes of Salmonella enterica serovar Typhimurium (S. Typhimurium) encode two unrelated dinucleoside polyphosphate (Np n N) hydrolases. For…”
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Nudix Hydrolases That Degrade Dinucleoside and Diphosphoinositol Polyphosphates Also Have 5-Phosphoribosyl 1-Pyrophosphate (PRPP) Pyrophosphatase Activity That Generates the Glycolytic Activator Ribose 1,5-Bisphosphate by Fisher, David I., Safrany, Stephen T., Strike, Peter, McLennan, Alexander G., Cartwright, Jared L.

“…A total of 17 Nudix hydrolases were tested for their ability to hydrolyze 5-phosphoribosyl 1-pyrophosphate (PRPP). All 11 enzymes that were active toward…”
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Mouse Nudt13 is a Mitochondrial Nudix Hydrolase with NAD(P)H Pyrophosphohydrolase Activity by Abdelraheim, Salama R., Spiller, David G., McLennan, Alexander G.

“…The mammalian NUDT13 protein possesses a sequence motif characteristic of the NADH pyrophosphohydrolase subfamily of Nudix hydrolases. Due to the persistent…”
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Structure and Substrate-binding Mechanism of Human Ap4A Hydrolase by Swarbrick, James D, Buyya, Smrithi, Gunawardana, Dilantha, Gayler, Kenwyn R, McLennan, Alexander G, Gooley, Paul R

“…Asymmetric diadenosine 5′,5‴- P 1 , P 4 -tetraphosphate (Ap 4 A) hydrolases play a major role in maintaining homeostasis by cleaving the metabolite…”
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The g5R (D250) Gene of African Swine Fever Virus Encodes a Nudix Hydrolase That Preferentially Degrades Diphosphoinositol Polyphosphates by Cartwright, Jared L, Safrany, Stephen T, Dixon, Linda K, Darzynkiewicz, Edward, Stepinski, Janusz, Burke, Richard, McLennan, Alexander G

“…Author's Correction ( vol. 76 , p. 6864 ) Author's Correction ( vol. 76 , p. 6864 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed…”
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Diadenosine 5', 5'''-P 1,P 4-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication by Marriott, Andrew S, Copeland, Nikki A, Cunningham, Ryan, Wilkinson, Mark C, McLennan, Alexander G, Jones, Nigel J

“…The level of intracellular diadenosine 5', 5'''-P 1,P 4-tetraphosphate (Ap4A) increases several fold in mammalian cells treated with non-cytotoxic doses of…”
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Decapitation: poxvirus makes RNA lose its head by McLennan, Alexander G.

“…Cellular infection by vaccinia virus involves the controlled degradation of early, intermediate and late viral mRNAs, and increased turnover of host mRNAs. A…”
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Dinucleoside polyphosphates—friend or foe? by McLennan, Alexander G

“…Despite being known for over 30 years, the functions of the dinucleoside polyphosphates, such as diadenosine 5′,5′′′- P 1, P 4-tetraphosphate (Ap 4A) and…”
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Diadenosine 5', 5'''-P(1),P(4)-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication by Marriott, Andrew S, Copeland, Nikki A, Cunningham, Ryan, Wilkinson, Mark C, McLennan, Alexander G, Jones, Nigel J

“…The level of intracellular diadenosine 5', 5'''-P(1),P(4)-tetraphosphate (Ap4A) increases several fold in mammalian cells treated with non-cytotoxic doses of…”
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Analysis of the Catalytic and Binding Residues of the Diadenosine Tetraphosphate Pyrophosphohydrolase from Caenorhabditis elegans by Site-directed Mutagenesis by Abdelghany, Hend M, Bailey, Scott, Blackburn, G Michael, Rafferty, John B, McLennan, Alexander G

“…The contributions to substrate binding and catalysis of 13 amino acid residues of the Caenorhabditis elegans diadenosine tetraphosphate pyrophosphohydrolase…”
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Folate Synthesis: An Old Enzyme Identified by McLennan, Alexander G.

“…In this issue of Structure, Amzel, Bessman, and colleagues ( Gabelli et al., 2007) present the crystal structure of a 17 kDa Nudix hydrolase from Escherichia…”
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Correlation of intracellular diadenosine triphosphate (Ap3 A) with apoptosis in Fhit-positive HEK293 cells by Fisher, David I, McLennan, Alexander G

“…Abstract The pro-apoptotic Fhit tumor suppressor protein binds and hydrolyses diadenosine triphosphate (Ap3 A) and diadenosine tetraphosphate (Ap4 A) in vitro…”
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Recent progress in the study of the intracellular functions of diadenosine polyphosphates by McLennan, Alexander G., Barnes, Larry D., Blackburn, G. Michael, Brenner, Charles, Guranowski, Andrzej, Miller, Andrew D., Rovira, Juan Manuel, Rotllán, Pedro, Soria, Bernat, Tanner, Julian A., Sillero, Antonio

“…Recent developments in the effort to understand the metabolism and function of the intracellular dinucleoside polyphosphates were described by nine speakers…”
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