Search Results - "Mclaughlin, P."

An ecological network approach to predict ecosystem service vulnerability to species losses by Keyes, Aislyn A., McLaughlin, John P., Barner, Allison K., Dee, Laura E.

“…Human-driven threats are changing biodiversity, impacting ecosystem services. The loss of one species can trigger secondary extinctions of additional species,…”
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In silico analyses of penicillin binding proteins in Burkholderia pseudomallei uncovers SNPs with utility for phylogeography, species differentiation, and sequence typing by McLaughlin, Heather P, Gulvik, Christopher A, Sue, David

“…Burkholderia pseudomallei causes melioidosis. Sequence typing this pathogen can reveal geographical origin and uncover epidemiological associations. Here, we…”
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The chemistry and biology of febrifugine and halofuginone by McLaughlin, Noel P., Evans, Paul, Pines, Mark

“…The trans-2,3-disubstituted piperidine, quinazolinone-containing natural product febrifugine (also known as dichroine B) and its synthetic analogue,…”
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The experiences and beliefs of people with severe haemophilia and healthcare professionals on pain management, and their views of using exercise as an aspect of intervention: a qualitative study by McLaughlin, P., Hurley, M., Chowdary, P., Stephensen, D., Khair, K.

“…To explore the experiences, views and beliefs of people with severe haemophilia and healthcare professionals (HCPs) on approaches for pain management, as well…”
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Parasites affect food web structure primarily through increased diversity and complexity by Dunne, Jennifer A, Lafferty, Kevin D, Dobson, Andrew P, Hechinger, Ryan F, Kuris, Armand M, Martinez, Neo D, McLaughlin, John P, Mouritsen, Kim N, Poulin, Robert, Reise, Karsten, Stouffer, Daniel B, Thieltges, David W, Williams, Richard J, Zander, Claus Dieter

“…Comparative research on food web structure has revealed generalities in trophic organization, produced simple models, and allowed assessment of robustness to…”
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How does a lifetime of painful experiences influence sensations and beliefs about pain in adults with severe haemophilia? A qualitative study by McLaughlin, P., Hurley, M., Chowdary, P., Stephensen, D., Khair, K.

“…To explore the life experiences of pain in people with severe haemophilia and understand how such experiences influence beliefs and sensation of pain in…”
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HIV-1 Tat and cocaine impact mitochondrial epigenetics: effects on DNA methylation by Doke, Mayur, Jeganathan, Venkatesh, McLaughlin, Jay P., Samikkannu, Thangavel

“…Human immunodeficiency virus (HIV) infection and the psychostimulant drug cocaine are known to induce epigenetic changes in DNA methylation that are linked…”
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Region-specific effects of HIV-1 Tat on intrinsic electrophysiological properties of pyramidal neurons in mouse prefrontal cortex and hippocampus by Cirino, Thomas J, Harden, Scott W, McLaughlin, Jay P, Frazier, Charles J

“…Human immunodeficiency virus (HIV)-1 transactivator of transcription protein (Tat) is a viral protein that promotes transcription of the HIV genome and…”
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Guidelines for the management of acute joint bleeds and chronic synovitis in haemophilia: A United Kingdom Haemophilia Centre Doctors' Organisation (UKHCDO) guideline by Hanley, J, McKernan, A, Creagh, M D, Classey, S, McLaughlin, P, Goddard, N, Briggs, P J, Frostick, S, Giangrande, P, Wilde, J, Thachil, J, Chowdary, P

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Optical microscopy reveals the dynamic nature of B. pseudomallei morphology during β-lactam antimicrobial susceptibility testing by McLaughlin, Heather P, Bugrysheva, Julia, Sue, David

“…In Gram-negative species, β-lactam antibiotics target penicillin binding proteins (PBPs) resulting in morphological alterations of bacterial cells…”
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Daily cost of an intensive care unit day: The contribution of mechanical ventilation by Dasta, Joseph F, McLaughlin, Trent P, Mody, Samir H, Piech, Catherine Tak

“…OBJECTIVE:To quantify the mean daily cost of intensive care, identify key factors associated with increased cost, and determine the incremental cost of…”
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Identification and Pharmacological Characterization of a Low-Liability Antinociceptive Bifunctional MOR/DOR Cyclic Peptide by Li, Yangmei, Eans, Shainnel O, Ganno-Sherwood, Michelle, Eliasof, Abbe, Houghten, Richard A, McLaughlin, Jay P

“…Peptide-based opioid ligands are important candidates for the development of novel, safer, and more effective analgesics to treat pain. To develop…”
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A kinase inhibitor screen identifies a dual cdc7/CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy by McLaughlin, Ronan P, He, Jichao, van der Noord, Vera E, Redel, Jevin, Foekens, John A, Martens, John W M, Smid, Marcel, Zhang, Yinghui, van de Water, Bob

“…The effective treatment of triple-negative breast cancer (TNBC) remains a profound clinical challenge. Despite frequent epidermal growth factor receptor (EGFR)…”
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Transforming Palmyra Atoll to native-tree dominance will increase net carbon storage and reduce dissolved organic carbon reef runoff by Longley-Wood, Kate, Engels, Mary, Lafferty, Kevin D, McLaughlin, John P, Wegmann, Alex

“…Native forests on tropical islands have been displaced by non-native species, leading to calls for their transformation. Simultaneously, there is increasing…”
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Rapid antimicrobial susceptibility testing and β-lactam-induced cell morphology changes of Gram-negative biological threat pathogens by optical screening by McLaughlin, Heather P, Sue, David

“…For Yersinia pestis, Burkholderia pseudomallei, and Burkholderia mallei, conventional broth microdilution (BMD) is considered the gold standard for…”
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Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration by Rayala, Ramanjaneyulu, Tiller, Annika, Majumder, Shahayra A, Stacy, Heather M, Eans, Shainnel O, Nedovic, Aleksandra, McLaughlin, Jay P, Cudic, Predrag

“…New strategies facilitate the design of cyclic peptides which can penetrate the brain. We have designed a bicyclic peptide, OL-CTOP, composed of the sequences…”
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Multi-targeted kinase inhibition alleviates mTOR inhibitor resistance in triple-negative breast cancer by He, Jichao, McLaughlin, Ronan P., van der Noord, Vera, Foekens, John A., Martens, John W. M., van Westen, Gerard, Zhang, Yinghui, van de Water, Bob

“…Purpose Owing to its genetic heterogeneity and acquired resistance, triple-negative breast cancer (TNBC) is not responsive to single-targeted therapy, causing…”
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Metal-Free Deoxygenation of Carbohydrates by Adduci, Laura L., McLaughlin, Matthew P., Bender, Trandon A., Becker, Jennifer J., Gagné, Michel R.

“…The conversion of readily available cellulosic biomass to valuable feedstocks and fuels is an attrative goal but a challenging transformation that requires the…”
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Group Psychotherapy for Borderline Personality Disorder: A Meta-Analysis of Randomized-Controlled Trials by McLaughlin, Stephanie P. B, Barkowski, Sarah, Burlingame, Gary M, Strauss, Bernard, Rosendahl, Jenny

“…Treatment guidelines for borderline personality disorder (BPD) recommend psychotherapy as an important, if not essential, component of patient care. The…”
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Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection by Sundar, Vaishnavi, McLaughlin, Jay P, Samikkannu, Thangavel

“…HIV is a major global public threat burdening society, yet the exact mechanism of HIV pathogenesis needs to be elucidated. In the era of epigenetic therapy,…”
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