Search Results - "Mclaughlin, H"

Atomic structure of the APC/C and its mechanism of protein ubiquitination by Chang, Leifu, Zhang, Ziguo, Yang, Jing, McLaughlin, Stephen H., Barford, David

“…The anaphase-promoting complex (APC/C) is a multimeric RING E3 ubiquitin ligase that controls chromosome segregation and mitotic exit. Its regulation by…”
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Molecular architecture and mechanism of the anaphase-promoting complex by Chang, Leifu, Zhang, Ziguo, Yang, Jing, McLaughlin, Stephen H., Barford, David

“…The ubiquitination of cell cycle regulatory proteins by the anaphase-promoting complex/cyclosome (APC/C) controls sister chromatid segregation, cytokinesis and…”
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Droplet Volume Variability and Impact on Digital PCR Copy Number Concentration Measurements by Emslie, Kerry R, H. McLaughlin, Jacob L, Griffiths, Kate, Forbes-Smith, Michael, Pinheiro, Leonardo B, Burke, Daniel G

“…Digital polymerase chain reaction (dPCR) is increasingly being adopted by reference material producers and metrology institutes for value assignment, and for…”
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Activation of GCN2 by the ribosomal P-stalk by Inglis, Alison J., Masson, Glenn R., Shao, Sichen, Perisic, Olga, McLaughlin, Stephen H., Hegde, Ramanujan S., Williams, Roger L.

“…Cells dynamically adjust their protein translation profile to maintain homeostasis in changing environments. During nutrient stress, the kinase general control…”
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Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome by Yan, Kaige, Yang, Jing, Zhang, Ziguo, McLaughlin, Stephen H., Chang, Leifu, Fasci, Domenico, Ehrenhofer-Murray, Ann E., Heck, Albert J. R., Barford, David

“…In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome stability and prevents aneuploidy. Kinetochores are large protein…”
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Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome by Yatskevich, Stanislau, Muir, Kyle W, Bellini, Dom, Zhang, Ziguo, Yang, Jing, Tischer, Thomas, Predin, Masa, Dendooven, Tom, McLaughlin, Stephen H, Barford, David

“…Kinetochores assemble onto specialized centromeric CENP-A (centromere protein A) nucleosomes (CENP-A ) to mediate attachments between chromosomes and the…”
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SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling by Elliott, Paul R., Leske, Derek, Hrdinka, Matous, Bagola, Katrin, Fiil, Berthe K., McLaughlin, Stephen H., Wagstaff, Jane, Volkmar, Norbert, Christianson, John C., Kessler, Benedikt M., Freund, Stefan M.V., Komander, David, Gyrd-Hansen, Mads

“…The linear ubiquitin chain assembly complex (LUBAC) regulates immune signaling, and its function is regulated by the deubiquitinases OTULIN and CYLD, which…”
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Synthetic Genetic Polymers Capable of Heredity and Evolution by Pinheiro, Vitor B., Taylor, Alexander I., Cozens, Christopher, Abramov, Mikhail, Renders, Marleen, Zhang, Su, Chaput, John C., Wengel, Jesper, Peak-Chew, Sew-Yeu, McLaughlin, Stephen H., Herdewijn, Piet, Holliger, Philipp

“…Genetic information storage and processing rely on just two polymers, DNA and RNA, yet whether their role reflects evolutionary history or fundamental…”
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Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing by Stoll, Guido A., Oda, Shun-ichiro, Chong, Zheng-Shan, Yu, Minmin, McLaughlin, Stephen H., Modis, Yorgo

“…Transcription of transposable elements is tightly regulated to prevent genome damage. KRAB domain-containing zinc finger proteins (KRAB-ZFPs) and…”
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A detailed EIS study of boron doped diamond electrodes decorated with gold nanoparticles for high sensitivity mercury detection by McLaughlin, Maeve H. S., Pakpour-Tabrizi, Alexander C., Jackman, Richard B.

“…This work compares the electrochemical impedance response of polished and unpolished boron doped diamond (BDD) electrodes, during mercury detection…”
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Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state by Chang, Leifu, Yang, Jing, Jo, Chang Hwa, Boland, Andreas, Zhang, Ziguo, McLaughlin, Stephen H., Abu-Thuraia, Afnan, Killoran, Ryan C., Smith, Matthew J., Côté, Jean-Francois, Barford, David

“…DOCK (dedicator of cytokinesis) proteins are multidomain guanine nucleotide exchange factors (GEFs) for RHO GTPases that regulate intracellular actin dynamics…”
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A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases by Kiss, Leo, Zeng, Jingwei, Dickson, Claire F., Mallery, Donna L., Yang, Ji-Chun, McLaughlin, Stephen H., Boland, Andreas, Neuhaus, David, James, Leo C.

“…The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein…”
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Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly by Fischer, Elyse S., Yu, Conny W. H., Hevler, Johannes F., McLaughlin, Stephen H., Maslen, Sarah L., Heck, Albert J. R., Freund, Stefan M. V., Barford, David

“…In response to improper kinetochore-microtubule attachments in mitosis, the spindle assembly checkpoint (SAC) assembles the mitotic checkpoint complex (MCC) to…”
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A systematic approach to assessing the clinical significance of genetic variants by Duzkale, H, Shen, J, McLaughlin, H, Alfares, A, Kelly, MA, Pugh, TJ, Funke, BH, Rehm, HL, Lebo, MS

“…Molecular genetic testing informs diagnosis, prognosis, and risk assessment for patients and their family members. Recent advances in low‐cost, high‐throughput…”
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Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi by Galindo, Antonio, Soler, Nicolas, McLaughlin, Stephen H., Yu, Minmin, Williams, Roger L., Munro, Sean

“…The GTPase Arf1 is the major regulator of vesicle traffic at both the cis- and trans-Golgi. Arf1 is activated at the cis-Golgi by the guanine nucleotide…”
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Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21 by Dickson, Claire, Fletcher, Adam J, Vaysburd, Marina, Yang, Ji-Chun, Mallery, Donna L, Zeng, Jingwei, Johnson, Christopher M, McLaughlin, Stephen H, Skehel, Mark, Maslen, Sarah, Cruickshank, James, Huguenin-Dezot, Nicolas, Chin, Jason W, Neuhaus, David, James, Leo C

“…Cell surface Fc receptors activate inflammation and are tightly controlled to prevent autoimmunity. Antibodies also simulate potent immune signalling from…”
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Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly by Liu, Yi, Gupta, Gagan D., Barnabas, Deepak D., Agircan, Fikret G., Mehmood, Shahid, Wu, Di, Coyaud, Etienne, Johnson, Christopher M., McLaughlin, Stephen H., Andreeva, Antonina, Freund, Stefan M. V., Robinson, Carol V., Cheung, Sally W. T., Raught, Brian, Pelletier, Laurence, van Breugel, Mark

“…Centrosomes are required for faithful chromosome segregation during mitosis. They are composed of a centriole pair that recruits and organizes the…”
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The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle by Arnaudo, Nadia, Fernández, Israel S, McLaughlin, Stephen H, Peak-Chew, Sew Y, Rhodes, Daniela, Martino, Fabrizio

“…N-terminal acetylation of Sir3 is essential for heterochromatin establishment and maintenance in yeast, but its mechanism of action is unknown. The crystal…”
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RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs by McClintock, Mark A, Dix, Carly I, Johnson, Christopher M, McLaughlin, Stephen H, Maizels, Rory J, Hoang, Ha Thi, Bullock, Simon L

“…Polarised mRNA transport is a prevalent mechanism for spatial control of protein synthesis. However, the composition of transported ribonucleoprotein particles…”
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Crenactin forms actin-like double helical filaments regulated by arcadin-2 by Izoré, Thierry, Kureisaite-Ciziene, Danguole, McLaughlin, Stephen H, Löwe, Jan

“…The similarity of eukaryotic actin to crenactin, a filament-forming protein from the crenarchaeon supports the theory of a common origin of Crenarchaea and…”
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