Search Results - "Mclaren, Paul"

HIV-1 and human genetic variation by McLaren, Paul J., Fellay, Jacques

“…Over the past four decades, research on the natural history of HIV infection has described how HIV wreaks havoc on human immunity and causes AIDS. HIV host…”
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A new look at human leukocyte antigen variation in HIV; functional clustering to enhance power for discovery of host genetic associations by McLaren, Paul J

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The impact of host genetic variation on infection with HIV-1 by McLaren, Paul J, Carrington, Mary

“…An effect of host genetic variation on susceptibility to HIV-1 was identified early in the pandemic. McLaren and Carrington discuss the extent to which…”
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Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity by Krapp, Christian, Hotter, Dominik, Gawanbacht, Ali, McLaren, Paul J., Kluge, Silvia F., Stürzel, Christina M., Mack, Katharina, Reith, Elisabeth, Engelhart, Susanne, Ciuffi, Angela, Hornung, Veit, Sauter, Daniel, Telenti, Amalio, Kirchhoff, Frank

“…Guanylate binding proteins (GBPs) are an interferon (IFN)-inducible subfamily of guanosine triphosphatases (GTPases) with well-established activity against…”
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HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids and the cellular receptor Siglec-1 by Izquierdo-Useros, Nuria, Lorizate, Maier, McLaren, Paul J, Telenti, Amalio, Kräusslich, Hans-Georg, Martinez-Picado, Javier

“…Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might…”
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HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation by Arora, Jatin, Pierini, Federica, McLaren, Paul J, Carrington, Mary, Fellay, Jacques, Lenz, Tobias L

“…Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic diversity. A hallmark for balancing selection in humans is the…”
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A Proposed Research Agenda for Ethical, Legal, Social, and Historical Studies at the Intersection of Infectious and Genetic Disease by Cholette, François, McLaren, Paul J

“…Over the past two decades there has been a rapid expansion in our understanding of how human genetic variability impacts susceptibility and severity of…”
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Gene expression profiling identifies candidate biomarkers for new latent tuberculosis infections. A cohort study by Herrera, Mariana, Keynan, Yoav, McLaren, Paul J, Isaza, Juan Pablo, Abrenica, Bernard, López, Lucelly, Marin, Diana, Rueda, Zulma Vanessa

“…Objective To determine the gene expression profile in individuals with new latent tuberculosis infection (LTBI), and to compare them with people with active…”
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Exome Sequencing of a Blastomycosis Case–Control Cohort From Manitoba and Northwestern Ontario, Canada by Jankowski, Paul, Lee, Emma R., Embil, John, Keynan, Yoav, McLaren, Paul J.

“…ABSTRACT Background Blastomycosis is a pulmonary disease caused by Blastomyces spp., a group of pathogenic dimorphic fungi endemic to a number of geographic…”
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Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control by Bartha, István, McLaren, Paul J, Brumme, Chanson, Harrigan, Richard, Telenti, Amalio, Fellay, Jacques

“…We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data…”
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Expansion of cytotoxic tissue-resident CD8+ T cells and CCR6+CD161+ CD4+ T cells in the nasal mucosa following mRNA COVID-19 vaccination by Ssemaganda, Aloysious, Nguyen, Huong Mai, Nuhu, Faisal, Jahan, Naima, Card, Catherine M., Kiazyk, Sandra, Severini, Giulia, Keynan, Yoav, Su, Ruey-Chyi, Ji, Hezhao, Abrenica, Bernard, McLaren, Paul J., Ball, T. Blake, Bullard, Jared, Van Caeseele, Paul, Stein, Derek, McKinnon, Lyle R.

“…Vaccines against SARS-CoV-2 have shown high efficacy in clinical trials, yet a full immunologic characterization of these vaccines, particularly within the…”
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Severe viral respiratory infections in children with IFIH1 loss-of-function mutations by Asgari, Samira, Schlapbach, Luregn J., Anchisi, Stéphanie, Hammer, Christian, Bartha, Istvan, Junier, Thomas, Mottet-Osman, Geneviève, Posfay-Barbe, Klara M., Longchamp, David, Stocker, Martin, Cordey, Samuel, Kaiser, Laurent, Riedel, Thomas, Kenna, Tony, Long, Deborah, Schibler, Andreas, Telenti, Amalio, Tapparel, Caroline, McLaren, Paul J., Garcin, Dominique, Fellay, Jacques

“…Viral respiratory infections are usually mild and self-limiting; still they exceptionally result in life-threatening infections in previously healthy children…”
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Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses by Hammer, Christian, Begemann, Martin, McLaren, Paul J., Bartha, István, Michel, Angelika, Klose, Beate, Schmitt, Corinna, Waterboer, Tim, Pawlita, Michael, Schulz, Thomas F., Ehrenreich, Hannelore, Fellay, Jacques

“…The magnitude of the human antibody response to viral antigens is highly variable. To explore the human genetic contribution to this variability, we performed…”
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Minding the gap in HIV host genetics: opportunities and challenges by Gingras, Shanelle N., Tang, David, Tuff, Jeffrey, McLaren, Paul J.

“…Genome-wide association studies (GWAS) have been successful in identifying and confirming novel genetic variants that are associated with diverse HIV…”
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Analysis of stop-gain and frameshift variants in human innate immunity genes by Rausell, Antonio, Mohammadi, Pejman, McLaren, Paul J, Bartha, Istvan, Xenarios, Ioannis, Fellay, Jacques, Telenti, Amalio

“…Loss-of-function variants in innate immunity genes are associated with Mendelian disorders in the form of primary immunodeficiencies. Recent resequencing…”
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Exome sequencing and the genetic basis of complex traits by Kiezun, Adam, Garimella, Kiran, Do, Ron, Stitziel, Nathan O, Neale, Benjamin M, McLaren, Paul J, Gupta, Namrata, Sklar, Pamela, Sullivan, Patrick F, Moran, Jennifer L, Hultman, Christina M, Lichtenstein, Paul, Magnusson, Patrik, Lehner, Thomas, Shugart, Yin Yao, Price, Alkes L, de Bakker, Paul I W, Purcell, Shaun M, Sunyaev, Shamil R

“…Shamil Sunyaev and colleagues present exome sequencing methods and their applications in studies to identify the genetic basis of human complex traits. They…”
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Interaction of the Host and Viral Genome and Their Influence on HIV Disease by Tough, Riley H, McLaren, Paul J

“…The course of Human Immunodeficiency Virus type 1 (HIV) infection is a dynamic interplay in which both host and viral genetic variation, among other factors,…”
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The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome by Bartha, István, Rausell, Antonio, McLaren, Paul J, Mohammadi, Pejman, Tardaguila, Manuel, Chaturvedi, Nimisha, Fellay, Jacques, Telenti, Amalio

“…Sequencing projects have identified large numbers of rare stop-gain and frameshift variants in the human genome. As most of these are observed in the…”
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Decreased Immune Activation in Resistance to HIV-1 Infection Is Associated with an Elevated Frequency of CD4+CD25+FOXP3+ Regulatory T Cells by Card, Catherine M., McLaren, Paul J., Wachihi, Charles, Kimani, Joshua, Plummer, Francis A., Fowke, Keith R.

“…Human immunodeficiency virus (HIV)–resistant commercial sex workers provide a unique opportunity to study correlates of protection associated with natural…”
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Disentangling human tolerance and resistance against HIV by Regoes, Roland R, McLaren, Paul J, Battegay, Manuel, Bernasconi, Enos, Calmy, Alexandra, Günthard, Huldrych F, Hoffmann, Matthias, Rauch, Andri, Telenti, Amalio, Fellay, Jacques

“…In ecology, "disease tolerance" is defined as an evolutionary strategy of hosts against pathogens, characterized by reduced or absent pathogenesis despite high…”
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