Search Results - "Mckinney, Sheri"

Cholinergic Mesopontine Signals Govern Locomotion and Reward through Dissociable Midbrain Pathways by Xiao, Cheng, Cho, Jounhong Ryan, Zhou, Chunyi, Treweek, Jennifer B., Chan, Ken, McKinney, Sheri L., Yang, Bin, Gradinaru, Viviana

“…The mesopontine tegmentum, including the pedunculopontine and laterodorsal tegmental nuclei (PPN and LDT), provides major cholinergic inputs to midbrain and…”
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Nicotine Activation of α4 Receptors: Sufficient for Reward, Tolerance, and Sensitization by Tapper, Andrew R., McKinney, Sheri L., Nashmi, Raad, Schwarz, Johannes, Deshpande, Purnima, Labarca, Cesar, Whiteaker, Paul, Marks, Michael J., Collins, Allan C., Lester, Henry A.

“…The identity of nicotinic receptor subtypes sufficient to elicit both the acute and chronic effects of nicotine dependence is unknown. We engineered mutant…”
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Chronic Nicotine Selectively Enhances α4β2 Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway by Xiao, Cheng, Nashmi, Raad, McKinney, Sheri, Cai, Haijiang, McIntosh, J. Michael, Lester, Henry A.

“…These electrophysiological experiments, in slices and intact animals, study the effects of in vivo chronic exposure to nicotine on functional α4β2* nAChRs in…”
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Chronic Nicotine Cell Specifically Upregulates Functional α4 Nicotinic Receptors: Basis for Both Tolerance in Midbrain and Enhanced Long-Term Potentiation in Perforant Path by Nashmi, Raad, Xiao, Cheng, Deshpande, Purnima, McKinney, Sheri, Grady, Sharon R., Whiteaker, Paul, Huang, Qi, McClure-Begley, Tristan, Lindstrom, Jon M., Labarca, Cesar, Collins, Allan C., Marks, Michael J., Lester, Henry A.

“…Understanding effects of chronic nicotine requires identifying the neurons and synapses whose responses to nicotine itself, and to endogenous acetylcholine,…”
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Nicotinic receptor subtype-selective circuit patterns in the subthalamic nucleus by Xiao, Cheng, Miwa, Julie M, Henderson, Brandon J, Wang, Ying, Deshpande, Purnima, McKinney, Sheri L, Lester, Henry A

“…The glutamatergic subthalamic nucleus (STN) exerts control over motor output through nuclei of the basal ganglia. High-frequency electrical stimuli in the STN…”
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Structural differences determine the relative selectivity of nicotinic compounds for native α4β2-, α6β2-, α3β4- and α7-nicotine acetylcholine receptors by Grady, Sharon R., Drenan, Ryan M., Breining, Scott R., Yohannes, Daniel, Wageman, Charles R., Fedorov, Nikolai B., McKinney, Sheri, Whiteaker, Paul, Bencherif, Merouane, Lester, Henry A., Marks, Michael J.

“…Mammalian brain expresses multiple nicotinic acetylcholine receptor (nAChR) subtypes that differ in subunit composition, sites of expression and…”
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GABA Transporter Deficiency Causes Tremor, Ataxia, Nervousness, and Increased GABA-Induced Tonic Conductance in Cerebellum by Chiu, Chi-Sung, Brickley, Stephen, Jensen, Kimmo, Southwell, Amber, Mckinney, Sheri, Cull-Candy, Stuart, Mody, Istvan, Lester, Henry A

“…GABA transporter subtype 1 (GAT1) knock-out (KO) mice display normal reproduction and life span but have reduced body weight (female, -10%; male, -20%) and…”
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Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function by O'Neill, Heidi C., Laverty, Duncan C., Patzlaff, Natalie E., Cohen, Bruce N., Fonck, Carlos, McKinney, Sheri, McIntosh, J. Michael, Lindstrom, Jon M., Lester, Henry A., Grady, Sharon R., Marks, Michael J.

“…Several mutations in α4 or β2 nicotinic receptor subunits are linked to autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). One such missense mutation…”
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Nicotine responses in hypersensitive and knockout alpha 4 mice account for tolerance to both hypothermia and locomotor suppression in wild-type mice by Tapper, Andrew R, McKinney, Sheri L, Marks, Michael J, Lester, Henry A

“…Nicotinic receptors containing the alpha 4 subunit (alpha 4* nAChRs) have high sensitivity and are widely expressed in the central nervous system, yet their…”
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γ-Aminobutyric Acid Type A Receptors Modulate cAMP-Mediated Long-Term Potentiation and Long-Term Depression at Monosynaptic CA3-CA1 Synapses by Yu, Tzu-ping, McKinney, Sheri, Lester, Henry A., Davidson, Norman

“…cAMP induces a protein-synthesis-dependent late phase of long-term potentiation (LTP) at CA3-CA1 synapses in acute hippocampal slices. Herein we report…”
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Menthol Enhances Nicotine Reward-Related Behavior by Potentiating Nicotine-Induced Changes in nAChR Function, nAChR Upregulation, and DA Neuron Excitability by Henderson, Brandon J, Wall, Teagan R, Henley, Beverley M, Kim, Charlene H, McKinney, Sheri, Lester, Henry A

“…Understanding why the quit rate among smokers of menthol cigarettes is lower than non-menthol smokers requires identifying the neurons that are altered by…”
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Cholinergic Modulation of Locomotion and Striatal Dopamine Release Is Mediated by α6α4 Nicotinic Acetylcholine Receptors by Drenan, Ryan M., Grady, Sharon R., Steele, Andrew D., McKinney, Sheri, Patzlaff, Natalie E., McIntosh, J. Michael, Marks, Michael J., Miwa, Julie M., Lester, Henry A.

“…Dopamine (DA) release in striatum is governed by firing rates of midbrain DA neurons, striatal cholinergic tone, and nicotinic ACh receptors (nAChRs) on DA…”
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In Vivo Activation of Midbrain Dopamine Neurons via Sensitized, High-Affinity α6 ∗ Nicotinic Acetylcholine Receptors by Drenan, Ryan M., Grady, Sharon R., Whiteaker, Paul, McClure-Begley, Tristan, McKinney, Sheri, Miwa, Julie M., Bupp, Sujata, Heintz, Nathaniel, McIntosh, J. Michael, Bencherif, Merouane, Marks, Michael J., Lester, Henry A.

“…α6-containing (α6 ∗) nicotinic ACh receptors (nAChRs) are selectively expressed in dopamine (DA) neurons and participate in cholinergic transmission. We…”
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Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons by Srinivasan, Rahul, Henley, Beverley M, Henderson, Brandon J, Indersmitten, Tim, Cohen, Bruce N, Kim, Charlene H, McKinney, Sheri, Deshpande, Purnima, Xiao, Cheng, Lester, Henry A

“…Retrospective epidemiological studies show an inverse correlation between susceptibility to Parkinson's disease and a person's history of tobacco use. Animal…”
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Protein profiling in the habenula after chronic (–)‐menthol exposure in mice by Mulcahy, Matthew J., Huard, Stephanie M., Paulo, Joao A., Wang, Jonathan H., McKinney, Sheri, Marks, Michael J., Henderson, Brandon J., Lester, Henry A.

“…The identification of proteins that are altered following nicotine/tobacco exposure can facilitate and positively impact the investigation of related diseases…”
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Brain Region-Specific nAChR and Associated Protein Abundance Alterations Following Chronic Nicotine and/or Menthol Exposure by Mulcahy, Matthew J, Huard, Stephanie M, Paulo, Joao A, Wang, Jonathan H, McKinney, Sheri, Henderson, Brandon J, Lester, Henry A

“…The identification of biomarkers that are altered following nicotine/tobacco exposure can facilitate the investigation of tobacco-related diseases. Nicotinic…”
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Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors by Henderson, Brandon J, Srinivasan, Rahul, Nichols, Weston A, Dilworth, Crystal N, Gutierrez, Diana F, Mackey, Elisha D W, McKinney, Sheri, Drenan, Ryan M, Richards, Christopher I, Lester, Henry A

“…Chronic exposure to nicotine up-regulates high sensitivity nicotinic acetylcholine receptors (nAChRs) in the brain. This up-regulation partially underlies…”
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Assembly of α4β2 Nicotinic Acetylcholine Receptors Assessed with Functional Fluorescently Labeled Subunits: Effects of Localization, Trafficking, and Nicotine-Induced Upregulation in Clonal Mammalian Cells and in Cultured Midbrain Neurons by Nashmi, Raad, Dickinson, Mary E., McKinney, Sheri, Jareb, Mark, Labarca, Cesar, Fraser, Scott E., Lester, Henry A.

“…Fura-2 recording of Ca 2+ influx was used to show that incubation in 1 μ m nicotine (2-6 d) upregulates several pharmacological components of acetylcholine…”
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Effects of Menthol on α3β4∗ Nicotinic Receptors by Patowary, Suparna, Mackey, Elisha D.W., McKinney, Sheri L., Deshpande, Purnima, Henderson, Brandon J., Biener, Gabriel, Raicu, Valerica, Lester, Henry A.

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Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2-, alpha 6 beta 2-, alpha 3 beta 4- and alpha 7-nicotine acetylcholine receptors by Grady, Sharon R, Drenan, Ryan M, Breining, Scott R, Yohannes, Daniel, Wageman, Charles R, Fedorov, Nikolai B, McKinney, Sheri, Whiteaker, Paul, Bencherif, Merouane, Lester, Henry A, Marks, Michael J

“…Mammalian brain expresses multiple nicotinic acetylcholine receptor (nAChR) subtypes that differ in subunit composition, sites of expression and…”
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