Search Results - "Mckillop, Iain H."
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Role of fatty acid binding proteins (FABPs) in cancer development and progression
Published in Cellular signalling (01-10-2019)“…Fatty acid binding proteins (FABPs) are small, water soluble proteins that bind long chain fatty acids and other biologically active ligands to facilitate…”
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IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease
Published in Journal of hepatology (01-05-2020)“…Chronic alcohol consumption is a leading risk factor for the development of hepatocellular carcinoma (HCC), which is associated with a marked increase in…”
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Altered fatty acid‐binding protein 4 (FABP4) expression and function in human and animal models of hepatocellular carcinoma
Published in Liver international (01-06-2018)“…Background and Aims Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related mortality. Risk factors for developing HCC include viral…”
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Role of AMPK-SREBP Signaling in Regulating Fatty Acid Binding-4 (FABP4) Expression following Ethanol Metabolism
Published in Biology (Basel, Switzerland) (04-11-2022)“…Fatty acid binding protein-4 ( ) is not normally expressed in the liver but is induced in alcohol-dependent liver disease (ALD)). This study sought to identify…”
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Chronic Ethanol Feeding Accelerates Hepatocellular Carcinoma Progression in a Sex-Dependent Manner in a Mouse Model of Hepatocarcinogenesis
Published in Alcoholism, clinical and experimental research (01-04-2012)“…Background: Chronic ethanol consumption increases the risk of hepatic cirrhosis and hepatocellular carcinoma (HCC). While sex differences exist in…”
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Fatty acid binding protein-4 promotes alcohol-dependent hepatosteatosis and hepatocellular carcinoma progression
Published in Translational oncology (01-01-2021)“…•Fatty liver disease (hepatosteatosis) is a hallmark of ALD and NAFLD.•FABP4 is normally expressed in adipocytes and macrophages.•ALD leads to FABP4…”
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Treatment of spontaneously ruptured hepatocellular carcinoma: use of laparoscopic microwave ablation and washout
Published in HPB (Oxford, England) (01-03-2021)“…Ruptured, or bleeding, hepatocellular carcinoma (rHCC) is a relatively rare disease presentation associated with high acute mortality rates. This study sought…”
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Platelet Aggregation, Mitochondrial Function and Morphology in Cold Storage: Impact of Resveratrol and Cytochrome c Supplementation
Published in Cells (Basel, Switzerland) (30-12-2022)“…Donated platelets are critical components of hemostasis management. Extending platelet storage beyond the recommended guidelines (5 days, 22 °C) is of clinical…”
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Structure and function of proteins in hydrated choline dihydrogen phosphate ionic liquid
Published in Physical chemistry chemical physics : PCCP (01-01-2012)“…Ionic liquids are being intensely studied as promising media for the stabilization of proteins and other biomolecules. Choline dihydrogen phosphate (CDHP) has…”
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Diet-Induced Obesity Enhances Progression of Hepatocellular Carcinoma through Tenascin-C/Toll-Like Receptor 4 Signaling
Published in The American journal of pathology (2016)“…Obesity is an independent risk factor for the development of liver fibrosis/cirrhosis and hepatocellular carcinoma (HCC). Tenascin-C (TnC), an extracellular…”
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The effect of alcohol on Sirt1 expression and function in animal and human models of hepatocellular carcinoma (HCC)
Published in Advances in experimental medicine and biology (01-01-2015)“…Chronic heavy alcohol use is an independent risk factor for developing hepatocellular carcinoma (HCC). Sirtuin-1 (Sirt1) is a NAD+-dependent deacetylase…”
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Resveratrol attenuates hypoxic injury in a primary hepatocyte model of hemorrhagic shock and resuscitation
Published in The journal of trauma and acute care surgery (01-02-2014)“…Oxidative stress following hemorrhagic shock and resuscitation (HSR) is regulated, in part, by inflammatory and apoptotic mediators such as necrosis factor κB…”
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Expression and function of lysophosphatidic acid receptors (LPARs) 1 and 3 in human hepatic cancer progenitor cells
Published in Oncotarget (19-01-2016)“…Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver and is characterized by rapid tumor expansion and metastasis. Lysophosphatidic…”
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Targeting collagen expression in alcoholic liver disease
Published in World journal of gastroenterology : WJG (28-05-2011)“…Alcoholic liver disease (ALD) is a leading cause of liver disease and liver-related deaths globally, particularly in developed nations. Liver fibrosis is a…”
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Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression
Published in Biomolecules (Basel, Switzerland) (01-04-2024)“…Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with…”
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MicroRNA expression following activated protein C treatment during septic shock
Published in The Journal of surgical research (01-06-2013)“…Abstract Background Sepsis induces systemic stress by augmenting inflammatory and procoagulant responses, resulting in microvascular dysfunction and end organ…”
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Decreased aquaporin expression leads to increased resistance to apoptosis in hepatocellular carcinoma
Published in Cancer letters (18-05-2007)“…Abstract Cells undergoing apoptosis are characterized by decreased cell size due to changes in intracellular ion concentration and rapid, aquaporin…”
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Alcoholic and non-alcoholic steatohepatitis
Published in Experimental and molecular pathology (01-12-2014)“…This paper is based upon the “Charles Lieber Satellite Symposia” organized by Manuela G. Neuman at the Research Society on Alcoholism (RSA) Annual Meetings,…”
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Alcoholic liver disease: Clinical and translational research
Published in Experimental and molecular pathology (01-12-2015)“…The present review spans a broad spectrum of topics dealing with alcoholic liver disease (ALD), including clinical research, translational research,…”
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Lysophosphatidic acid receptor expression and function in human hepatocellular carcinoma
Published in The Journal of surgical research (01-03-2013)“…Abstract Background Lysophosphatidic acid (LPA) is a ubiquitously expressed phospholipid that regulates diverse cellular functions. Previously identified LPA…”
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