Search Results - "Mckie, Andrew"

The role of Dcytb in iron metabolism: an update by McKie, Andrew T

“…Dcytb (duodenal cytochrome b) is an iron-regulated ferric reductase highly expressed in duodenal enterocytes. Its location and strong regulation by iron has…”
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Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells by Chung, Bomee, Matak, Pavle, McKie, Andrew T, Sharp, Paul

“…Obesity is a major global health problem and is associated with low-grade inflammation and, in a number of cases, poor iron status. We speculated that the…”
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Enhanced insulin signaling and its downstream effects in iron-overloaded primary hepatocytes from hepcidin knock-out mice by James, Jithu V., Varghese, Joe, Mckie, Andrew T., Vaulont, Sophie, Jacob, Molly

“…Increased body iron stores have been implicated in the pathogenesis of diabetes mellitus. However, the molecular mechanisms involved are unclear. The liver…”
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Identification of an Intestinal Heme Transporter by Shayeghi, Majid, Latunde-Dada, Gladys O., Oakhill, Jonathan S., Laftah, Abas H., Takeuchi, Ken, Halliday, Neil, Khan, Yasmin, Warley, Alice, McCann, Fiona E., Hider, Robert C., Frazer, David M., Anderson, Gregory J., Vulpe, Christopher D., Simpson, Robert J., McKie, Andrew T.

“…Dietary heme iron is an important nutritional source of iron in carnivores and omnivores that is more readily absorbed than non-heme iron derived from…”
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Dcytb (Cybrd1) functions as both a ferric and a cupric reductase in vitro by Wyman, Steven, Simpson, Robert J., McKie, Andrew T., Sharp, Paul A.

“…MDCK cells expressing an inducible duodenal cytochrome b-green fluorescent protein (Dcytb-EGFP) fusion construct were used to investigate the function of…”
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Iron and oxygen sensing: a tale of 2 interacting elements? by Simpson, Robert J, McKie, Andrew T

“…Iron and oxygen metabolism are intimately linked with one another. A change in the level of either metabolite results in activation of common pathways. At the…”
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Regulation of Intestinal Iron Absorption: The Mucosa Takes Control? by Simpson, Robert J., McKie, Andrew T.

“…Two studies ( Shah et al., 2009; Mastrogiannaki et al., 2009) show that the hypoxia inducible factor HIF-2α is a major player in regulating iron absorption by…”
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Duodenal reductase activity and spleen iron stores are reduced and erythropoiesis is abnormal in Dcytb knockout mice exposed to hypoxic conditions by Choi, Jeehyea, Masaratana, Patarabutr, Latunde-Dada, Gladys O, Arno, Matthew, Simpson, Robert J, McKie, Andrew T

“…Duodenal cytochrome b (Dcytb, Cybrd1) is a ferric reductase localized in the duodenum that is highly upregulated in circumstances of increased iron absorption…”
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Duodenal cytochrome B expression stimulates iron uptake by human intestinal epithelial cells by Latunde-Dada, Gladys O, Simpson, Robert J, McKie, Andrew T

“…Duodenal cytochrome B (Dcytb) is localized principally in the apical membrane of the enterocyte. It is thought to act as a ferric reductase that furnishes…”
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Tumour necrosis factor alpha causes hypoferraemia and reduced intestinal iron absorption in mice by Laftah, Abas H, Sharma, Naveen, Brookes, Matthew J, McKie, Andrew T, Simpson, Robert J, Iqbal, Tariq H, Tselepis, Chris

“…Cytokines are implicated in the anaemia of chronic disease by reducing erythropoiesis and increasing iron sequestration in the reticuloendotheial system…”
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Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling by Chaston, Timothy B, Matak, Pavle, Pourvali, Katayoun, Srai, Surjit K, McKie, Andrew T, Sharp, Paul A

“…Hepcidin negatively regulates systemic iron homeostasis in response to inflammation and elevated serum iron. Conversely, hepcidin expression is diminished in…”
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Characterization of the transition-metal-binding properties of hepcidin by Tselepis, Chris, Ford, Samuel J, McKie, Andrew T, Vogel, Wolfgang, Zoller, Heinz, Simpson, Robert J, Diaz Castro, Javier, Iqbal, Tariq H, Ward, Douglas G

“…Accumulating evidence suggests that hepcidin, a 25-residue peptide hormone, is the master regulator of iron metabolism. Further evidence suggests that the five…”
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The transcription factor ATOH8 is regulated by erythropoietic activity and regulates HAMP transcription and cellular pSMAD1,5,8 levels by Patel, Neeta, Varghese, Joe, Masaratana, Patarabutr, Latunde‐Dada, Gladys O., Jacob, Molly, Simpson, Robert J., McKie, Andrew T.

“…Summary ATOH8 has previously been shown to be an iron‐regulated transcription factor, however its role in iron metabolism is not known. ATOH8 expression in…”
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Hepcidin suppression in β-thalassemia is associated with the down-regulation of atonal homolog 8 by Upanan, Supranee, McKie, Andrew T., Latunde-Dada, Gladys O., Roytrakul, Sittiruk, Uthaipibull, Chairat, Pothacharoen, Peraphan, Kongtawelert, Prachya, Fucharoen, Suthat, Srichairatanakool, Somdet

“…Atonal homolog 8 (ATOH8) is defined as a positive regulator of hepcidin transcription, which links erythropoietic activity with iron-sensing molecules. In the…”
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Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1) by Laftah, Abas H., Latunde-Dada, Gladys O., Fakih, Sarah, Hider, Robert C., Simpson, Robert J., McKie, Andrew T.

“…Haem carrier protein 1 (HCP1) was originally identified and characterised as a mammalian haem transporter. However, recent evidence has shown that it is also a…”
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Physiology and molecular biology of dietary iron absorption by Miret, Silvia, Simpson, Robert J, McKie, Andrew T

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Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats by Frazer, David M., Wilkins, Sarah J., Becker, Erika M., Vulpe, Christopher D., Mckie, Andrew T., Trinder, Deborah, Anderson, Gregory J.

“…Background & Aims: Hepcidin is an antimicrobial peptide thought to be involved in the regulation of intestinal iron absorption. To further investigate its role…”
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Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism by Lambe, Teresa, Simpson, Robert J., Dawson, Sara, Bouriez-Jones, Tiphaine, Crockford, Tanya L., Lepherd, Michelle, Latunde-Dada, Gladys O., Robinson, Hannah, Raja, Kishor B., Campagna, Dean R., Villarreal, Guadalupe, Ellory, J. Clive, Goodnow, Christopher C., Fleming, Mark D., McKie, Andrew T., Cornall, Richard J.

“…Hereditary forms of iron-deficiency anemia, including animal models, have taught us much about the normal physiologic control of iron metabolism. However, the…”
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A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation by McKie, Andrew T, Marciani, Paola, Rolfs, Andreas, Brennan, Karen, Wehr, Kristina, Barrow, Dalna, Miret, Silvia, Bomford, Adrian, Peters, Timothy J, Farzaneh, Farzin, Hediger, Matthias A, Hentze, Matthias W, Simpson, Robert J

“…Iron absorption by the duodenal mucosa is initiated by uptake of ferrous Fe(II) iron across the brush border membrane and culminates in transfer of the metal…”
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An Iron-Regulated Ferric Reductase Associated with the Absorption of Dietary Iron by McKie, Andrew T., Barrow, Dalna, Latunde-Dada, Gladys O., Rolfs, Andreas, Sager, Giamal, Mudaly, Elida, Mudaly, Melitta, Richardson, Christopher, Barlow, David, Bomford, Adrian, Peters, Timothy J., Raja, Kishor B., Shirali, Sima, Hediger, Matthias A., Farzaneh, Farzin, Simpson, Robert J.

“…The ability of intestinal mucosa to absorb dietary ferric iron is attributed to the presence of a brush-border membrane reductase activity that displays…”
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