Search Results - "Mckeating, J"

Hepatitis C virus and the brain by Fletcher, N. F., McKeating, J. A.

“…Hepatitis C virus (HCV) is an enveloped, positive‐strand RNA virus of the family Flaviviridae that primarily infects hepatocytes, causing acute and chronic…”
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TNF superfamily members promote hepatitis C virus entry via an NF-κB and myosin light chain kinase dependent pathway by Fletcher, N F, Clark, A R, Balfe, P, McKeating, J A

“…Preventing virally induced liver disease begins with an understanding of the host factors that define susceptibility to infection. Hepatitis C virus (HCV) is a…”
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Neutralizing Antibody Response during Acute and Chronic Hepatitis C Virus Infection by Logvinoff, C., Major, M. E., Oldach, D., Heyward, S., Talal, A., Balfe, P., Feinstone, S. M., Alter, H., Rice, C. M., McKeating, J. A.

“…Little is known about the role of Abs in determining the outcome of hepatitis C virus (HCV) infection. By using infectious retroviral pseudotypes bearing HCV…”
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Diverse Hepatitis C Virus Glycoproteins Mediate Viral Infection in a CD81-Dependent Manner by MCKEATING, J. A, ZHANG, L. Q, BALFE, P, LOGVINOFF, C, FLINT, M, ZHANG, J, YU, J, BUTERA, D, HO, D. D, DUSTIN, L. B, RICE, C. M

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Hepatoma polarization limits CD81 and hepatitis C virus dynamics by Harris, H. J., Clerte, C., Farquhar, M. J., Goodall, M., Hu, K., Rassam, P., Dosset, P., Wilson, G. K., Balfe, P., IJzendoorn, S. C., Milhiet, P. E., McKeating, J. A.

“…Summary Many viruses target the polarized epithelial apex during host invasion. In contrast, hepatitis C virus (HCV) engages receptors at the basal surface of…”
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Differential effect of p7 inhibitors on hepatitis C virus cell-to-cell transmission by Meredith, L.W., Zitzmann, N., McKeating, J.A.

“…•p7 Inhibitors were tested for their ability to block HCV cell-free and cell-to-cell transmission.•p7 Inhibitor BIT225 reduced the infectivity of diverse HCV…”
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Hepatitis C virus entry: possible targets for therapy by Timpe, J M, McKeating, J A

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Shorter Survival in Advanced Human Immunodeficiency Virus Type 1 Infection Is More Closely Associated with T Lymphocyte Activation than with Plasma Virus Burden or Virus Chemokine Coreceptor Usage by Giorgi, Janis V., Hultin, Lance E., McKeating, Jane A., Johnson, Timothy D., Owens, Bronwyn, Jacobson, Lisa P., Shih, Roger, Lewis, Julie, Wiley, Dorothy J., Phair, John P., Wolinsky, Steven M., Detels, Roger

“…To define predictors of survival time in late human immunodeficiency virus type 1 (HIV-1) disease, long- and short-duration survivors were studied after their…”
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Primary hepatocytes as targets for Hepatitis C virus replication by Farquhar, M. J., McKeating, J. A.

“…Much of our current understanding of hepatits C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed…”
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Humoral Immune Response in Acute Hepatitis C Virus Infection by Netski, Dale M., Mosbruger, Tim, Depla, Erik, Maertens, Geert, Ray, Stuart C., Hamilton, Robert G., Roundtree, Stacy, Thomas, David L., McKeating, Jane, Cox, Andrea

“…Background. There is little information on the timing, magnitude, specificity, and clinical relevance of the antibody response to acute hepatitis C virus (HCV)…”
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Lentiviral hepatitis B pseudotype entry requires sodium taurocholate co-transporting polypeptide and additional hepatocyte-specific factors by Meredith, L W, Hu, K, Cheng, X, Howard, C R, Baumert, T F, Balfe, P, van de Graaf, K F, Protzer, U, McKeating, J A

“…Hepatitis B virus (HBV) is one of the world's major unconquered infections, resulting in progressive liver disease, and current treatments rarely cure…”
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P188 A HIGH-THROUGHPUT HDV INFECTION MODEL SYSTEM FOR SCREENING OF ANTIVIRALS AND HOST-TARGETING COMPOUNDS by Verrier, E.R, Tawar, R.G, Schuster, C, Brino, L, Bach, C, Heydmann, L, Habersetzer, F, Doffoel, M, Mckeating, J, Sureau, C, Zeisel, M.B, Baumert, T.F

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Construction and characterization of chimeric hepatitis C virus E2 glycoproteins: analysis of regions critical for glycoprotein aggregation and CD81 binding by Patel, Arvind H, Wood, Jonny, Penin, Francois, Dubuisson, Jean, McKeating, J. A

“…MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK 1 Institut de Biologie et Chimie des Protéines, UPR 412 CNRS, 7 Passage du…”
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Truncated gp120 envelope glycoprotein of human immunodeficiency virus 1 elicits a broadly reactive neutralizing immune response by Jeffs, S. A, Shotton, C, Balfe, P, McKeating, J. A

“…Division of Retrovirology, NIBSC, Blanche Lane, South Mimms, Potters Bar, Herts EN6 3QG, UK 1 School of Biological Sciences, University of Surrey, Guildford,…”
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Characterization of Hepatitis C Virus E2 Glycoprotein Interaction with a Putative Cellular Receptor, CD81 by Flint, Mike, Maidens, Catherine, Loomis-Price, Larry D., Shotton, Christine, Dubuisson, Jean, Monk, Peter, Higginbottom, Adrian, Levy, Shoshana, McKeating, Jane A.

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Dissociation of gp120 from HIV-1 Virions Induced by Soluble CD4 by Moore, John P., McKeating, Jane A., Weiss, Robin A., Sattentau, Quentin J.

“…The CD4 antigen is the high affinity cellular receptor for the human immunodeficiency virus type-1 (HIV-1). Binding of recombinant soluble CD4 (sCD4) or the…”
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Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates by MOORE, J. P, MCKEATING, J. A, YAOXING HUANG, ASHKENAZI, A, HO, D. D

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Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120 by MCKEATING, J. A, SHOTTON, C, KAYMAN, S. C, WU, Z, PINTER, A, DEAN, C, SODROSKI, J, WEISS, R. A, CORDELL, J, GRAHAM, S, BALFE, P, SULLIVAN, N, CHARLES, M, PAGE, M, BOLMSTEDT, A, OLOFSSON, S

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Differential loss of envelope glycoprotein gp120 from virions of human immunodeficiency virus type 1 isolates: effects on infectivity and neutralization by MCKEATING, J. A, MCKNIGHT, A, MOORE, J. P

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Conformational epitope on gp120 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody by HO, D. D, MCKEATING, J. A, XI LING LI, MOUDGIL, T, DAAR, E. S, NAI-CHAU SUN, ROBINSON, J. E

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