Search Results - "Mcintosh, J Michael"

Nicotinic acetylcholine receptors in neuropathic and inflammatory pain by Hone, Arik J, McIntosh, J. Michael

“…Nicotinic acetylcholine receptors (nAChRs) are actively being investigated as therapeutic targets for the treatment of pain and inflammation, but despite more…”
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Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation by Hone, Arik J., McIntosh, J. Michael

“…Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated ion channels and function as such in the central and peripheral…”
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α9‐containing nicotinic acetylcholine receptors and the modulation of pain by Hone, Arik J, Servent, Denis, McIntosh, J Michael

“…Neuropathic pain is a complex and debilitating syndrome for which there are few effective pharmacological treatments. Opioid‐based medications are initially…”
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Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA by Azam, Layla, McIntosh, J Michael

“…J. Neurochem. (2012) 122, 1137–1144. The α9α10 nicotinic acetylcholine receptor (nAChR) may be a potential target in pathophysiology of the auditory system,…”
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Muscle Nicotinic Acetylcholine Receptors May Mediate Trans-Synaptic Signaling at the Mouse Neuromuscular Junction by Wang, Xueyong, McIntosh, J Michael, Rich, Mark M

“…Block of neurotransmitter receptors at the neuromuscular junction (NMJ) has been shown to trigger upregulation of the number of synaptic vesicles released…”
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Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain by Romero, Haylie K., Christensen, Sean B., Di Cesare Mannelli, Lorenzo, Gajewiak, Joanna, Ramachandra, Renuka, Elmslie, Keith S., Vetter, Douglas E., Ghelardini, Carla, Iadonato, Shawn P., Mercado, Jose L., Olivera, Baldomera M., McIntosh, J. Michael

“…Opioids are first-line drugs for moderate to severe acute pain and cancer pain. However, these medications are associated with severe side effects, and whether…”
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Rapid multi-directed cholinergic transmission in the central nervous system by Sethuramanujam, Santhosh, Matsumoto, Akihiro, deRosenroll, Geoff, Murphy-Baum, Benjamin, Grosman, Claudio, McIntosh, J Michael, Jing, Miao, Li, Yulong, Berson, David, Yonehara, Keisuke, Awatramani, Gautam B.

“…In many parts of the central nervous system, including the retina, it is unclear whether cholinergic transmission is mediated by rapid, point-to-point synaptic…”
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Alkaloid ligands enable function of homomeric human α10 nicotinic acetylcholine receptors by Hone, Arik J., McIntosh, J. Michael

“…In the nervous system, nicotinic acetylcholine receptors (nAChRs) rapidly transduce a chemical signal into one that is electrical via ligand-gated ion flux…”
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Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors by Azam, Layla, McIntosh, J Michael

“…Cysteine-rich peptides from the venom of cone snails ( Conus ) target a wide variety of different ion channels. One family of conopeptides, the α-conotoxins,…”
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The odyssey of marine pharmaceuticals: a current pipeline perspective by Mayer, Alejandro M.S, Glaser, Keith B, Cuevas, Carmen, Jacobs, Robert S, Kem, William, Little, R. Daniel, McIntosh, J. Michael, Newman, David J, Potts, Barbara C, Shuster, Dale E

“…The global marine pharmaceutical pipeline consists of three Food and Drug Administration (FDA) approved drugs, one EU registered drug, 13 natural products (or…”
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Alpha7 Nicotinic Acetylcholine Receptors Modulate Motivation to Self-Administer Nicotine: Implications for Smoking and Schizophrenia by BRUNZELL, Darlene H, MICHAEL MCLNTOSH, J

“…Individuals diagnosed with schizophrenia have an exceptionally high risk for tobacco dependence. Postmortem studies show that these individuals have…”
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The α9α10 nicotinic acetylcholine receptors antagonist α-conotoxin RgIA reverses colitis signs in murine dextran sodium sulfate model by AlSharari, Shakir D., Toma, Wisam, Mahmood, Hafiz M., Michael McIntosh, J., Imad Damaj, M.

“…Nicotinic acetylcholine receptors can regulate inflammation primarily through the vagus nerve via the cholinergic anti-inflammatory pathway. α9α10 nicotinic…”
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Conopeptides [V11L;V16D]ArIB and RgIA4: Powerful Tools for the Identification of Novel Nicotinic Acetylcholine Receptors in Monocytes by Grau, Veronika, Richter, Katrin, Hone, Arik J, McIntosh, J Michael

“…Venomous marine snails of the genus employ small peptides to capture prey, mainly osteichthyes, mollusks, and worms. A subset of these peptides known as…”
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Differential Control of Dopaminergic Excitability and Locomotion by Cholinergic Inputs in Mouse Substantia Nigra by Estakhr, Jasem, Abazari, Danya, Frisby, Kaitlyn, McIntosh, J. Michael, Nashmi, Raad

“…Understanding how dopaminergic (DA) neurons of the substantia nigra pars compacta (SNc) govern movements requires a detailed knowledge of how different…”
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α-Conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement by Di Cesare Mannelli, Lorenzo, Cinci, Lorenzo, Micheli, Laura, Zanardelli, Matteo, Pacini, Alessandra, McIntosh, J. Michael, Ghelardini, Carla

“…α-Conotoxin RgIA prevents the development of chronic pain, halts progression of damage in injured nerves, and limits downstream pathological alterations in…”
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Application of alpha1-antitrypsin in a rat model of veno-arterial extracorporeal membrane oxygenation by Edinger, Fabian, Schmitt, Christoph, Koch, Christian, McIntosh, J. Michael, Janciauskiene, Sabina, Markmann, Melanie, Sander, Michael, Padberg, Winfried, Grau, Veronika

“…Extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for patients suffering from respiratory or cardiac failure. The ECMO-associated…”
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Critical residue properties for potency and selectivity of α-Conotoxin RgIA towards α9α10 nicotinic acetylcholine receptors by Huynh, Peter N., Harvey, Peta J., Gajewiak, Joanna, Craik, David J., Michael McIntosh, J.

“…[Display omitted] The α9α10 nicotinic acetylcholine receptor (nAChR) has been characterized as an effective anti-pain target that functions through a…”
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Striatal α5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum by Exley, Richard, McIntosh, J Michael, Marks, Michael J, Maskos, Uwe, Cragg, Stephanie J

“…Polymorphisms in the gene for the α5 nicotinic acetylcholine receptor (nAChR) subunit are associated with vulnerability to nicotine addiction. However, the…”
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The α7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions by Bordia, Tanuja, McGregor, Matthew, Papke, Roger L., Decker, Michael W., Michael McIntosh, J., Quik, Maryka

“…The finding that smoking is inversely correlated with Parkinson's disease and that nicotine attenuates nigrostriatal damage in Parkinsonian animals supports…”
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αO-Conotoxin GeXIVA[1,2] Reduced Neuropathic Pain and Changed Gene Expression in Chronic Oxaliplatin-Induced Neuropathy Mice Model by Wang, Huanbai, Li, Xiaodan, Qiao, Yamin, Wang, Meiting, Wang, Wen, McIntosh, J Michael, Zhangsun, Dongting, Luo, Sulan

“…Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting painful neuropathy that occurs commonly during cancer management, which often leads to the…”
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