Search Results - "Mcintire, Larry"

Force-history dependence and cyclic mechanical reinforcement of actin filaments at the single molecular level by Lee, Hyunjung, Eskin, Suzanne G, Ono, Shoichiro, Zhu, Cheng, McIntire, Larry V

“…The actin cytoskeleton is subjected to dynamic mechanical forces over time and the history of force loading may serve as mechanical preconditioning. While the…”
Get full text

Mechanochemical coupling of formin-induced actin interaction at the level of single molecular complex by Li, Zhenhai, Lee, Hyunjung, Eskin, Suzanne G., Ono, Shoichiro, Zhu, Cheng, McIntire, Larry V.

“…Formins promote actin assembly and are involved in force-dependent cytoskeletal remodeling. However, how force alters the formin functions still needs to be…”
Get full text

Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds by Lee, Cho-yin, Lou, Jizhong, Wen, Kuo-kuang, McKane, Melissa, Eskin, Suzanne G., Ono, Shoichiro, Chien, Shu, Rubenstein, Peter A., Zhu, Cheng, McIntire, Larry V.

“…As a key element in the cytoskeleton, actin filaments are highly dynamic structures that constantly sustain forces. However, the fundamental question of how…”
Get full text

Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF by Yago, Tadayuki, Lou, Jizhong, Wu, Tao, Yang, Jun, Miner, Jonathan J, Coburn, Leslie, Lopez, Jose A, Cruz, Miguel A, Dong, Jing-Fei, McIntire, Larry V, McEver, Rodger P, Zhu, Cheng

“…Arterial blood flow enhances glycoprotein Ibα (GPIbα) binding to vWF, which initiates platelet adhesion to injured vessels. Mutations in the vWF A1 domain that…”
Get full text

Endothelial cell responses to atheroprone flow are driven by two separate flow components: low time-average shear stress and fluid flow reversal by Conway, Daniel E, Williams, Marcie R, Eskin, Suzanne G, McIntire, Larry V

“…To simulate the effects of shear stress in regions of the vasculature prone to developing atherosclerosis, we subjected human umbilical vein endothelial cells…”
Get more information

ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions by Dong, Jing-fei, Moake, Joel L., Nolasco, Leticia, Bernardo, Aubrey, Arceneaux, Wendy, Shrimpton, Corie N., Schade, Alicia J., McIntire, Larry V., Fujikawa, Kazuo, López, José A.

“…Thrombotic thrombocytopenic purpura (TTP) is a devastating thrombotic disorder caused by widespread microvascular thrombi composed of platelets and von…”
Get full text

Regulation of actin catch-slip bonds with a RhoA-formin module by Lee, Cho-yin, Lou, Jizhong, Wen, Kuo-Kuang, McKane, Melissa, Eskin, Suzanne G., Rubenstein, Peter A., Chien, Shu, Ono, Shoichiro, Zhu, Cheng, McIntire, Larry V.

“…The dynamic turnover of the actin cytoskeleton is regulated cooperatively by force and biochemical signaling. We previously demonstrated that actin…”
Get full text

Fond Memories of our Mentor J. David Hellums, Annals of Biomedical Engineering by Simon, Scott I., Mikos, Antonios G., McIntire, Larry V.

Get full text

Expression of CYP1A1 and CYP1B1 in human endothelial cells: regulation by fluid shear stress by Conway, Daniel E., Sakurai, Yumiko, Weiss, Daiana, Vega, J. David, Taylor, W. Robert, Jo, Hanjoong, Eskin, Suzanne G., Marcus, Craig B., McIntire, Larry V.

“…Aims CYP1A1 and CYP1B1, members of the cytochrome P450 protein family, are regulated by fluid shear stress. This study describes the effects of duration,…”
Get full text

From cellular to molecular mechanobiology by Zhu, Cheng, Lee, Cho-yin, McIntire, Larry V.

“…Mechanobiology at the cellular level is concerned with what phenotypes that cells exhibit to maintain homeostasis in their normal physiological mechanical…”
Get full text

Growth factor delivery for tissue engineering by BABENSEE, J. E, MCINTIRE, L. V, MIKOS, A. G

“…A tissue-engineered implant is a biologic-biomaterial combination in which some component of tissue has been combined with a biomaterial to create a device for…”
Get full text

DNA Microarray Reveals Changes in Gene Expression of Shear Stressed Human Umbilical Vein Endothelial Cells by McCormick, Susan M., Eskin, Suzanne G., McIntire, Larry V., Teng, Christina L., Lu, Chiung-Mei, Russell, Christopher G., Chittur, Krishnan K.

“…Using DNA microarray screening (GeneFilter 211, Research Genetics, Huntsville, AL) of mRNA from primary human umbilical vein endothelial cells (HUVEC), we…”
Get full text

Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers by Arya, Maneesh, Anvari, Bahman, Romo, Gabriel M., Cruz, Miguel A., Dong, Jing-Fei, McIntire, Larry V., Moake, Joel L., López, JoséA.

“…Ultralarge von Willebrand factor (ULVWF) multimers have been implicated in the pathogenesis of the catastrophic microangiopathic disorder, thrombotic…”
Get full text

The impact of biomechanics in tissue engineering and regenerative medicine by Butler, David L, Goldstein, Steven A, Guldberg, Robert E, Guo, X Edward, Kamm, Roger, Laurencin, Cato T, McIntire, Larry V, Mow, Van C, Nerem, Robert M, Sah, Robert L, Soslowsky, Louis J, Spilker, Robert L, Tranquillo, Robert T

“…Biomechanical factors profoundly influence the processes of tissue growth, development, maintenance, degeneration, and repair. Regenerative strategies to…”
Get more information

Host response to tissue engineered devices by Babensee, Julia E., Anderson, James M., McIntire, Larry V., Mikos, Antonios G.

“…The two main components of a tissue engineered device are the transplanted cells and the biomaterial, creating a device for the restoration or modification of…”
Get full text

Transmigration across activated endothelium induces transcriptional changes, inhibits apoptosis, and decreases antimicrobial protein expression in human monocytes by Williams, Marcie R., Sakurai, Yumiko, Zughaier, Susu M., Eskin, Suzanne G., McIntire, Larry V.

“…Monocyte transmigration across stimulated ECs promotes further monocyte recruitment, inhibits monocyte apoptosis, and leads to a reduction in antimicrobial…”
Get full text

Automated Selection of DAB-labeled Tissue for Immunohistochemical Quantification by Brey, Eric M, Lalani, Zahid, Johnston, Carol, Wong, Mark, McIntire, Larry V, Duke, Pauline J, Patrick, Charles W., Jr

“…The increased use of immunohistochemistry (IHC) in both clinical and basic research settings has led to the development of techniques for acquiring…”
Get full text

Blockade of adenosine diphosphate receptors P2Y12 and P2Y1 is required to inhibit platelet aggregation in whole blood under flow by Turner, Nancy A., Moake, Joel L., McIntire, Larry V.

“…Using heparinized whole blood and flow conditions, it was shown that adenosine 5′-diphosphate (ADP) receptors P2Y12 and P2Y1 are both important in direct…”
Get full text

Cyclic strain and motion control produce opposite oxidative responses in two human endothelial cell types by Sung, Hak-Joon, Yee, Andrew, Eskin, Suzanne G, McIntire, Larry V

“…The phenotype of endothelial cells (ECs) is specific to the vascular bed from which they originate. To examine how mechanical forces alter the phenotype of…”
Get more information

Endothelial metallothionein expression and intracellular free zinc levels are regulated by shear stress by Conway, Daniel E, Lee, Sungmun, Eskin, Suzanne G, Shah, Ankit K, Jo, Hanjoong, McIntire, Larry V

“…We examined the effects of fluid shear stress on metallothionein (MT) gene and protein expression and intracellular free zinc in mouse aorta and in human…”
Get more information