Search Results - "Mcinnes, I"

Protein kinase inhibitors in the treatment of inflammatory and autoimmune diseases by Patterson, H., Nibbs, R., McInnes, I., Siebert, S.

“…Summary Protein kinases mediate protein phosphorylation, which is a fundamental component of cell signalling, with crucial roles in most signal transduction…”
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Long-term safety of secukinumab in patients with moderate-to-severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis: integrated pooled clinical trial and post-marketing surveillance data by Deodhar, A, Mease, P J, McInnes, I B, Baraliakos, X, Reich, K, Blauvelt, A, Leonardi, C, Porter, B, Das Gupta, A, Widmer, A, Pricop, L, Fox, T

“…Secukinumab, a fully human immunoglobulin G1-kappa monoclonal antibody that directly inhibits interleukin (IL)-17A, has been shown to have robust efficacy in…”
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Alopecia areata is characterized by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease‐associated psychological morbidity by Bain, K.A., McDonald, E., Moffat, F., Tutino, M., Castelino, M., Barton, A., Cavanagh, J., Ijaz, U.Z., Siebert, S., McInnes, I.B., Astrand, A., Holmes, S., Milling, S.W.F.

“…Summary Background Alopecia areata (AA) is a common autoimmune disease, causing patchy hair loss that can progress to involve the entire scalp (totalis) or…”
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EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update by Agca, R, Heslinga, S C, Rollefstad, S, Heslinga, M, McInnes, I B, Peters, M J L, Kvien, T K, Dougados, M, Radner, H, Atzeni, F, Primdahl, J, Södergren, A, Wallberg Jonsson, S, van Rompay, J, Zabalan, C, Pedersen, T R, Jacobsson, L, de Vlam, K, Gonzalez-Gay, M A, Semb, A G, Kitas, G D, Smulders, Y M, Szekanecz, Z, Sattar, N, Symmons, D P M, Nurmohamed, M T

“…Patients with rheumatoid arthritis (RA) and other inflammatory joint disorders (IJD) have increased cardiovascular disease (CVD) risk compared with the general…”
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Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis by Haringman, J J, Gerlag, D M, Zwinderman, A H, Smeets, T J M, Kraan, M C, Baeten, D, McInnes, I B, Bresnihan, B, Tak, P P

“…Background: Previous work identified synovial sublining macrophage numbers as a potential biomarker for clinical efficacy in rheumatoid arthritis. Objective:…”
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EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis by Peters, M J L, Symmons, D P M, McCarey, D, Dijkmans, B A C, Nicola, P, Kvien, T K, McInnes, I B, Haentzschel, H, Gonzalez-Gay, M A, Provan, S, Semb, A, Sidiropoulos, P, Kitas, G, Smulders, Y M, Soubrier, M, Szekanecz, Z, Sattar, N, Nurmohamed, M T

“…To develop evidence-based EULAR recommendations for cardiovascular (CV) risk management in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS)…”
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European League Against Rheumatism (EULAR) recommendations for the management of psoriatic arthritis with pharmacological therapies: 2015 update by Gossec, L, Smolen, J S, Ramiro, S, de Wit, M, Cutolo, M, Dougados, M, Emery, P, Landewé, R, Oliver, S, Aletaha, D, Betteridge, N, Braun, J, Burmester, G, Cañete, J D, Damjanov, N, FitzGerald, O, Haglund, E, Helliwell, P, Kvien, T K, Lories, R, Luger, T, Maccarone, M, Marzo-Ortega, H, McGonagle, D, McInnes, I B, Olivieri, I, Pavelka, K, Schett, G, Sieper, J, van den Bosch, F, Veale, D J, Wollenhaupt, J, Zink, A, van der Heijde, D

“…Since the publication of the European League Against Rheumatism recommendations for the pharmacological treatment of psoriatic arthritis (PsA) in 2012, new…”
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Reflections on ‘older’ drugs: learning new lessons in rheumatology by Kerrigan, S. A., McInnes, I. B.

“…The management of rheumatic and musculoskeletal diseases has transformed over two decades of exciting discoveries regarding pathogenesis and innovative drug…”
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Ultrasonography of entheseal insertions in the lower limb in spondyloarthropathy by Balint, P V, Kane, D, Wilson, H, McInnes, I B, Sturrock, R D

“…Objective: To compare ultrasonography (US) with clinical examination in the detection of entheseal abnormality of the lower limb in patients with…”
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Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients by Kelly, S, Humby, F, Filer, A, Ng, N, Di Cicco, M, Hands, R E, Rocher, V, Bombardieri, M, D'Agostino, M A, McInnes, I B, Buckley, C D, Taylor, P C, Pitzalis, C

“…To determine the tolerability, safety and yield of synovial tissue in an early arthritis cohort using a minimally invasive, ultrasound (US)-guided, synovial…”
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Efficacy of secukinumab and adalimumab in patients with psoriatic arthritis and concomitant moderate‐to‐severe plaque psoriasis: results from EXCEED, a randomized, double‐blind head‐to‐head monotherapy study by Gottlieb, A.B., Merola, J.F., Reich, K., Behrens, F., Nash, P., Griffiths, C.E.M., Bao, W., Pellet, P., Pricop, L., McInnes, I.B.

“…Summary Background Secukinumab [an interleukin (IL)‐17A inhibitor] has demonstrated significantly higher efficacy vs. etanercept (a tumour necrosis factor…”
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European League Against Rheumatism recommendations for the management of psoriatic arthritis with pharmacological therapies by Gossec, L, Smolen, J S, Gaujoux-Viala, C, Ash, Z, Marzo-Ortega, H, van der Heijde, D, FitzGerald, O, Aletaha, D, Balint, P, Boumpas, D, Braun, J, Breedveld, F C, Burmester, G, Cañete, J D, de Wit, M, Dagfinrud, H, de Vlam, K, Dougados, M, Helliwell, P, Kavanaugh, A, Kvien, T K, Landewé, R, Luger, T, Maccarone, M, McGonagle, D, McHugh, N, McInnes, I B, Ritchlin, C, Sieper, J, Tak, P P, Valesini, G, Vencovsky, J, Winthrop, K L, Zink, A, Emery, P

“…Psoriatic arthritis (PsA) is a clinically heterogeneous disease. Clear consensual treatment guidance focused on the musculoskeletal manifestations of PsA would…”
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JAK Inhibitors in Rheumatology: Implications for Paediatric Syndromes? by Kerrigan, S. A., McInnes, I. B.

“…Purpose of Review Given the recent increase in the profile and use of Janus kinase inhibitors (JAKinibs) in adult patients with rheumatic diseases, we aimed to…”
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Interleukin‐33: a novel mediator with a role in distinct disease pathologies by Kurowska‐Stolarska, M., Hueber, A., Stolarski, B., McInnes, I. B.

“…Kurowska‐Stolarska M, Hueber A, Stolarski B, McInnes IB (Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences,…”
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Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice by Komai-Koma, M., Brombacher, F., Pushparaj, P. N., Arendse, B., McSharry, C., Alexander, J., Chaudhuri, R., Thomson, N. C., McKenzie, A. N. J., McInnes, I., Liew, F. Y., Xu, D.

“…Background The regulation and function of IgE in healthy individuals and in antigen‐naïve animals is not well understood. IL‐33 administration increases serum…”
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Treating rheumatoid arthritis to target: recommendations of an international task force by Smolen, Josef S, Aletaha, Daniel, Bijlsma, Johannes W J, Breedveld, Ferdinand C, Boumpas, Dimitrios, Burmester, Gerd, Combe, Bernard, Cutolo, Maurizio, de Wit, Maarten, Dougados, Maxime, Emery, Paul, Gibofsky, Alan, Gomez-Reino, Juan Jesus, Haraoui, Boulos, Kalden, Joachim, Keystone, Edward C, Kvien, Tore K, McInnes, Iain, Martin-Mola, Emilio, Montecucco, Carlomaurizio, Schoels, Monika, van der Heijde, Désirée, van der Heijde, Desirée

“…Aiming at therapeutic targets has reduced the risk of organ failure in many diseases such as diabetes or hypertension. Such targets have not been defined for…”
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Emplacement of the Argyle diamond deposit into an ancient rift zone triggered by supercontinent breakup by Olierook, Hugo K. H., Fougerouse, Denis, Doucet, Luc S., Liu, Yebo, Rayner, Murray J., Danišík, Martin, Condon, Daniel J., McInnes, Brent I. A., Jaques, A. Lynton, Evans, Noreen J., McDonald, Bradley J., Li, Zheng-Xiang, Kirkland, Christopher L., Mayers, Celia, Wingate, Michael T. D.

“…Argyle is the world’s largest source of natural diamonds, yet one of only a few economic deposits hosted in a Paleoproterozoic orogen. The geodynamic triggers…”
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Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells by Alivernini, S., Tolusso, B., Ferraccioli, G., Gremese, E., Kurowska‐Stolarska, M., McInnes, I. B.

“…Summary Acute inflammation is a complex and tightly regulated homeostatic process that includes leucocyte migration from the vasculature into tissues to…”
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IL‐33/ST2 signalling contributes to carrageenin‐induced innate inflammation and inflammatory pain: role of cytokines, endothelin‐1 and prostaglandin E2 by Zarpelon, AC, Cunha, TM, Alves‐Filho, JC, Pinto, LG, Ferreira, SH, McInnes, IB, Xu, D, Liew, FY, Cunha, FQ, Verri, WA

“…Background and Purpose IL‐33 signals through ST2 receptors and induces adaptive and innate inflammation. IL‐33/ST2 is involved in adaptive inflammation‐induced…”
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Clinical identification and treatment of a rapidly progressing disease state in patients with rheumatoid arthritis by Emery, P., McInnes, I. B., van Vollenhoven, R., Kraan, M. C.

“…Inflammation is the major factor driving the progression of structural damage in rheumatoid arthritis (RA); therefore, it is critical to achieve rapid…”
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