Search Results - "Mcgriskin, Rory"

RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling by Yao, Zhan, Gao, Yijun, Su, Wenjing, Yaeger, Rona, Tao, Jessica, Na, Na, Zhang, Ying, Zhang, Chao, Rymar, Andrey, Tao, Anthony, Timaul, Neilawattie M., Mcgriskin, Rory, Outmezguine, Nathaniel A., Zhao, HuiYong, Chang, Qing, Qeriqi, Besnik, Barbacid, Mariano, de Stanchina, Elisa, Hyman, David M, Bollag, Gideon, Rosen, Neal

“…Activating BRAF mutants and fusions signal as RAS-independent constitutively active dimers with the exception of BRAF V600 mutant alleles which can function as…”
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FGFR2-amplified gastroesophageal adenocarcinoma is a distinct genomic class: Lessons learned from a liquid biopsy platform by Shariff, Bushra, Barnett, Reagan, Dayyani, Farshid, Maron, Steven Brad, Klempner, Samuel J, Masannat, Jude, Drusbosky, Leylah, Mcgriskin, Rory, Mehta, Rutika

“…429 Background: Gastroesophageal cancers (GECs) are the 2 nd highest cause of cancer mortality globally. Biomarkers such as MMR, PD-L1, and HER2 are critical…”
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Circulating tumor DNA molecular analyses and real-world evidence outcomes of FGFR2 amplified gastroesophageal cancers by Shariff, Bushra, Barnett, Reagan M, Dayyani, Farshid, Maron, Steven B, Mcgriskin, Rory, Klempner, Samuel, Donderici, Elifnur Yay, Zhang, Nicole, Masannat, Jude, Drusbosky, Leylah M, Mehta, Rutika

“…In addition to the existing biomarkers HER2 and PD-L1, FGFR2b has become an area of interest for the development of new targeted-based treatment. Given that…”
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