Search Results - "Mcgovern, DERMOT P.B."

Paneth Cell Alterations in the Development and Phenotype of Crohn’s Disease by Stappenbeck, Thaddeus S, McGovern, Dermot P.B

“…Pathogenesis of Crohn’s disease (CD) involves immune and microbial dysregulation, induced by environmental factors in genetically susceptible individuals…”
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A Disease-Associated Microbial and Metabolomics State in Relatives of Pediatric Inflammatory Bowel Disease Patients by Jacobs, Jonathan P, Goudarzi, Maryam, Singh, Namita, Tong, Maomeng, McHardy, Ian H, Ruegger, Paul, Asadourian, Miro, Moon, Bo-Hyun, Ayson, Allyson, Borneman, James, McGovern, Dermot P.B, Fornace, Albert J, Braun, Jonathan, Dubinsky, Marla

“…Background & Aims Microbes may increase susceptibility to inflammatory bowel disease (IBD) by producing bioactive metabolites that affect immune activity and…”
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Defects in Nicotinamide-adenine Dinucleotide Phosphate Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease by Hayes, Patti, Dhillon, Sandeep, O’Neill, Kim, Thoeni, Cornelia, Hui, Ken Y, Elkadri, Abdul, Guo, Conghui H, Kovacic, Lidija, Aviello, Gabriella, Alvarez, Luis A, Griffiths, Anne M, Snapper, Scott B, Brant, Steven R, Doroshow, James H, Silverberg, Mark S, Peter, Inga, McGovern, Dermot P.B, Cho, Judy, Brumell, John H, Uhlig, Holm H, Bourke, Billy, Muise, Aleixo M, Knaus, Ulla G

“…Background & Aims Defects in intestinal innate defense systems predispose patients to inflammatory bowel disease (IBD). Reactive oxygen species (ROS) generated…”
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Genetics of Inflammatory Bowel Diseases by McGovern, Dermot P.B, Kugathasan, Subra, Cho, Judy H

“…In this review, we provide an update on genome-wide association studies (GWAS) in inflammatory bowel disease (IBD). In addition, we summarize progress in…”
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Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans by Ha, Connie W.Y., Martin, Anthony, Sepich-Poore, Gregory D., Shi, Baochen, Wang, Yizhou, Gouin, Kenneth, Humphrey, Gregory, Sanders, Karenina, Ratnayake, Yasiru, Chan, Kelvin S.L., Hendrick, Gustaf, Caldera, J.R., Arias, Christian, Moskowitz, Jacob E., Ho Sui, Shannan J., Yang, Shaohong, Underhill, David, Brady, Matthew J., Knott, Simon, Kaihara, Kelly, Steinbaugh, Michael J., Li, Huiying, McGovern, Dermot P.B., Knight, Rob, Fleshner, Phillip, Devkota, Suzanne

“…A mysterious feature of Crohn’s disease (CD) is the extra-intestinal manifestation of “creeping fat” (CrF), defined as expansion of mesenteric adipose tissue…”
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A Systematic Review of Monogenic Inflammatory Bowel Disease by Nambu, Ryusuke, Warner, Neil, Mulder, Daniel J., Kotlarz, Daniel, McGovern, Dermot P.B., Cho, Judy, Klein, Christoph, Snapper, Scott B., Griffiths, Anne M., Iwama, Itaru, Muise, Aleixo M.

“…Advances in genomic technologies have led to increasing reports of monogenic inflammatory bowel disease (IBD). Here, we systematically review the literature to…”
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A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia by Yang, Suk-Kyun, Hong, Myunghee, Baek, Jiwon, Choi, Hyunchul, Zhao, Wanting, Jung, Yusun, Haritunians, Talin, Ye, Byong Duk, Kim, Kyung-Jo, Park, Sang Hyoung, Park, Soo-Kyung, Yang, Dong-Hoon, Dubinsky, Marla, Lee, Inchul, McGovern, Dermot P B, Liu, Jianjun, Song, Kyuyoung

“…Kyuyoung Song and colleagues report the results of a two-stage association study of thiopurine-induced early leukopenia in individuals undergoing treatment for…”
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Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy by Shiao, Stephen L., Kershaw, Kathleen M., Limon, Jose J., You, Sungyong, Yoon, Junhee, Ko, Emily Y., Guarnerio, Jlenia, Potdar, Alka A., McGovern, Dermot P.B., Bose, Shikha, Dar, Tahir B., Noe, Paul, Lee, Jung, Kubota, Yuzu, Maymi, Viviana I., Davis, Madison J., Henson, Regina M., Choi, Rachel Y., Yang, Wensha, Tang, Jie, Gargus, Matthew, Prince, Alexander D., Zumsteg, Zachary S., Underhill, David M.

“…Studies suggest that the efficacy of cancer chemotherapy and immunotherapy is influenced by intestinal bacteria. However, the influence of the microbiome on…”
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Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies by Ouahed, Jodie, Spencer, Elizabeth, Kotlarz, Daniel, Shouval, Dror S, Kowalik, Matthew, Peng, Kaiyue, Field, Michael, Grushkin-Lerner, Leslie, Pai, Sung-Yun, Bousvaros, Athos, Cho, Judy, Argmann, Carmen, Schadt, Eric, Mcgovern, Dermot P B, Mokry, Michal, Nieuwenhuis, Edward, Clevers, Hans, Powrie, Fiona, Uhlig, Holm, Klein, Christoph, Muise, Aleixo, Dubinsky, Marla, Snapper, Scott B

“…Very early onset inflammatory bowel disease (VEO-IBD) reflects IBD presenting before 6 years of age. We provide an approach to diagnosis and management of…”
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Genetic Variants Synthesize to Produce Paneth Cell Phenotypes That Define Subtypes of Crohn's Disease by VanDussen, Kelli L, Liu, Ta-Chiang, Li, Dalin, Towfic, Fadi, Modiano, Nir, Winter, Rachel, Haritunians, Talin, Taylor, Kent D, Dhall, Deepti, Targan, Stephan R, Xavier, Ramnik J, McGovern, Dermot P.B, Stappenbeck, Thaddeus S

“…Background & Aims Genetic susceptibility loci for Crohn's disease (CD) are numerous, complex, and likely interact with undefined components of the environment…”
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The role of glycosylation in IBD by Theodoratou, Evropi, Campbell, Harry, Ventham, Nicholas T., Kolarich, Daniel, Pučić-Baković, Maja, Zoldoš, Vlatka, Fernandes, Daryl, Pemberton, Iain K., Rudan, Igor, Kennedy, Nicholas A., Wuhrer, Manfred, Nimmo, Elaine, Annese, Vito, McGovern, Dermot P. B., Satsangi, Jack, Lauc, Gordan

“…Key Points Studies of the role of glycans in IBD are focused on three areas: glycosylation patterns of intestinal mucins, serum glycan levels of glycoproteins…”
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Towards personalized care in IBD by Gerich, Mark E., McGovern, Dermot P. B.

“…Key Points Basic science advances herald an era in which IBD will be subcategorized on the basis of the involvement of specific molecular pathways Knowledge of…”
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Genome-wide Association Study Identifies African-Specific Susceptibility Loci in African Americans with Inflammatory Bowel Disease by Brant, Steven R, Okou, David T, Simpson, Claire L, Cutler, David J, Haritunians, Talin, Bradfield, Jonathan P, Chopra, Pankaj, Prince, Jarod, Begum, Ferdouse, Kumar, Archana, Huang, Chengrui, Venkateswaran, Suresh, Datta, Lisa W, Wei, Zhi, Thomas, Kelly, Herrinton, Lisa J, Klapproth, Jan-Micheal A, Quiros, Antonio J, Seminerio, Jenifer, Liu, Zhenqiu, Alexander, Jonathan S, Baldassano, Robert N, Dudley-Brown, Sharon, Cross, Raymond K, Dassopoulos, Themistocles, Denson, Lee A, Dhere, Tanvi A, Dryden, Gerald W, Hanson, John S, Hou, Jason K, Hussain, Sunny Z, Hyams, Jeffrey S, Isaacs, Kim L, Kader, Howard, Kappelman, Michael D, Katz, Jeffry, Kellermayer, Richard, Kirschner, Barbara S, Kuemmerle, John F, Kwon, John H, Lazarev, Mark, Li, Ellen, Mack, David, Mannon, Peter, Moulton, Dedrick E, Newberry, Rodney D, Osuntokun, Bankole O, Patel, Ashish S, Saeed, Shehzad A, Targan, Stephan R, Valentine, John F, Wang, Ming-Hsi, Zonca, Martin, Rioux, John D, Duerr, Richard H, Silverberg, Mark S, Cho, Judy H, Hakonarson, Hakon, Zwick, Michael E, McGovern, Dermot P.B, Kugathasan, Subra

“…Abstract Background & Aims The inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn’s disease (CD) cause significant morbidity and are…”
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A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn’s Disease and Human Gut Microbiome Composition by Li, Dalin, Achkar, Jean-Paul, Haritunians, Talin, Jacobs, Jonathan P, Hui, Ken Y, D'Amato, Mauro, Brand, Stephan, Radford-Smith, Graham, Halfvarson, Jonas, Niess, Jan-Hendrik, Kugathasan, Subra, Büning, Carsten, Schumm, L. Philip, Klei, Lambertus, Ananthakrishnan, Ashwin, Aumais, Guy, Baidoo, Leonard, Dubinsky, Marla, Fiocchi, Claudio, Glas, Jürgen, Milgrom, Raquel, Proctor, Deborah D, Regueiro, Miguel, Simms, Lisa A, Stempak, Joanne M, Targan, Stephan R, Törkvist, Leif, Sharma, Yashoda, Devlin, Bernie, Borneman, James, Hakonarson, Hakon, Xavier, Ramnik J, Daly, Mark, Brant, Steven R, Rioux, John D, Silverberg, Mark S, Cho, Judy H, Braun, Jonathan, McGovern, Dermot P.B, Duerr, Richard H

“…Background & Aims Genome-wide association studies have identified 200 inflammatory bowel disease (IBD) loci, but the genetic architecture of Crohn’s disease…”
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Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease by Somineni, Hari K., Nagpal, Sini, Venkateswaran, Suresh, Cutler, David J., Okou, David T., Haritunians, Talin, Simpson, Claire L., Begum, Ferdouse, Datta, Lisa W., Quiros, Antonio J., Seminerio, Jenifer, Mengesha, Emebet, Alexander, Jonathan S., Baldassano, Robert N., Dudley-Brown, Sharon, Cross, Raymond K., Dassopoulos, Themistocles, Denson, Lee A., Dhere, Tanvi A., Iskandar, Heba, Dryden, Gerald W., Hou, Jason K., Hussain, Sunny Z., Hyams, Jeffrey S., Isaacs, Kim L., Kader, Howard, Kappelman, Michael D., Katz, Jeffry, Kellermayer, Richard, Kuemmerle, John F., Lazarev, Mark, Li, Ellen, Mannon, Peter, Moulton, Dedrick E., Newberry, Rodney D., Patel, Ashish S., Pekow, Joel, Saeed, Shehzad A., Valentine, John F., Wang, Ming-Hsi, McCauley, Jacob L., Abreu, Maria T., Jester, Traci, Molle-Rios, Zarela, Palle, Sirish, Scherl, Ellen J., Kwon, John, Rioux, John D., Duerr, Richard H., Silverberg, Mark S., Zwick, Michael E., Stevens, Christine, Daly, Mark J., Cho, Judy H., Gibson, Greg, McGovern, Dermot P.B., Brant, Steven R., Kugathasan, Subra

“…Whether or not populations diverge with respect to the genetic contribution to risk of specific complex diseases is relevant to understanding the evolution of…”
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The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD) by Sarmento, Olga F., Svingen, Phyllis A., Xiong, Yuning, Sun, Zhifu, Bamidele, Adebowale O., Mathison, Angela J., Smyrk, Thomas C., Nair, Asha A., Gonzalez, Michelle M., Sagstetter, Mary R., Baheti, Saurabh, McGovern, Dermot P.B., Friton, Jessica J., Papadakis, Konstantinos A., Gautam, Goel, Xavier, Ramnik J., Urrutia, Raul A., Faubion, William A.

“…Regulatory T (Treg) cells expressing the transcription factor FOXP3 play a pivotal role in maintaining immunologic self-tolerance. We and others have shown…”
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The Unsolved Link of Genetic Markers and Crohn's Disease Progression: A North American Cohort Experience by O'Donnell, Sarah, Borowski, Krzysztof, Espin-Garcia, Osvaldo, Milgrom, Raquel, Kabakchiev, Boyko, Stempak, Joanne, Panikkath, Deepah, Eksteen, Bertus, Xu, Wei, Steinhart, A Hillary, Kaplan, Gilaad G, McGovern, Dermot P B, Silverberg, Mark S

“…While progress has been made in the identification of Crohn's disease (CD) susceptibility loci, efforts to identify a genetic basis for disease progression…”
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Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity in Crohn’s Disease by Gonsky, Rivkah, Fleshner, Phillip, Deem, Richard L, Biener-Ramanujan, Eva, Li, Dalin, Potdar, Alka A, Bilsborough, Janine, Yang, Shaohong, McGovern, Dermot P.B, Targan, Stephan R

“…Background & Aims Variants in the tumor necrosis factor superfamily member 15 gene ( TNFSF15 , also called TL1A ) have been associated with risk for…”
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Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans by Yang, Suk-Kyun, Hong, Myunghee, Oh, Hyunjung, Low, Hui-Qi, Jung, Seulgi, Ahn, Seonjoo, Kim, Youngjin, Baek, Jiwon, Lee, Cue Hyunkyu, Kim, Eunji, Kim, Kyung Mo, Ye, Byong Duk, Kim, Kyung-Jo, Park, Sang Hyoung, Lee, Ho-Su, Lee, Inchul, Shin, Hyoung Doo, Han, Buhm, McGovern, Dermot P.B, Liu, Jianjun, Song, Kyuyoung

“…Recent genome-wide association studies have identified more than 200 regions that affect susceptibility to inflammatory bowel disease (IBD). However,…”
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A Multidisciplinary Approach to Biopsychosocial Care for Adults With Inflammatory Bowel Disease: A Pilot Study by Lee, Chang Kyun, Melmed, Gil Y, Mann, Amy, Danovitch, Itai, Hedrick, Rebecca, McGovern, Dermot P B, Targan, Stephan, Shih, David, Vasiliauskas, Eric, IsHak, Waguih William, Feldman, Edward

“…Abstract Background This study reports on the logistics and feasibility of a novel multidisciplinary approach to biopsychosocial care at a tertiary adult…”
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