Search Results - "Mcdevitt, R."

Radiopharmaceutical therapy in cancer: clinical advances and challenges by Sgouros, George, Bodei, Lisa, McDevitt, Michael R., Nedrow, Jessie R.

“…Radiopharmaceutical therapy (RPT) is emerging as a safe and effective targeted approach to treating many types of cancer. In RPT, radiation is systemically or…”
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Paradoxical glomerular filtration of carbon nanotubes by Ruggiero, Alessandro, Villa, Carlos H., Bander, Evan, Rey, Diego A., Berqkvist, Magnus, Batt, Carl A., Manova-Todorova, Katia, Deen, William M., Scheinberg, David A., McDevitt, Michael R., Weinbaum, Sheldon

“…The molecular weight cutoff for glomerular filtration is thought to be 30—50 kDa. Here we report rapid and efficient filtration of molecules 10—20 times that…”
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Realizing the potential of the Actinium-225 radionuclide generator in targeted alpha particle therapy applications by Miederer, Matthias, Scheinberg, David A., McDevitt, Michael R.

“…Alpha particle-emitting isotopes have been proposed as novel cytotoxic agents for augmenting targeted therapy. Properties of alpha particle radiation such as…”
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Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury by Alidori, Simone, Akhavein, Nima, Thorek, Daniel L J, Behling, Katja, Romin, Yevgeniy, Queen, Dawn, Beattie, Bradley J, Manova-Todorova, Katia, Bergkvist, Magnus, Scheinberg, David A, McDevitt, Michael R

“…RNA interference has tremendous yet unrealized potential to treat a wide range of illnesses. Innovative solutions are needed to protect and selectively deliver…”
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The effect of herbs and their associated essential oils on performance, dietary digestibility and gut microflora in chickens from 7 to 28 days of age by Cross, D.E., McDevitt, R.M., Hillman, K., Acamovic, T.

“…1. The effect of the dietary inclusion of 5 culinary herbs or their essential oils on the growth, digestibility and intestinal microflora status in female…”
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Actinium-225 in targeted alpha-particle therapeutic applications by Scheinberg, David A, McDevitt, Michael R

“…Alpha particle-emitting isotopes are being investigated in radioimmunotherapeutic applications because of their unparalleled cytotoxicity when targeted to…”
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Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization by Nolan, Daniel J, Ciarrocchi, Alessia, Mellick, Albert S, Jaggi, Jaspreet S, Bambino, Kathryn, Gupta, Sunita, Heikamp, Emily, McDevitt, Michael R, Scheinberg, David A, Benezra, Robert, Mittal, Vivek

“…Tumors build vessels by cooption of pre-existing vasculature and de novo recruitment of bone marrow (BM)-derived endothelial progenitor cells (EPCs). However,…”
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Tumor Targeting with Antibody-Functionalized, Radiolabeled Carbon Nanotubes by McDevitt, Michael R, Chattopadhyay, Debjit, Kappel, Barry J, Jaggi, Jaspreet Singh, Schiffman, Scott R, Antczak, Christophe, Njardarson, Jon T, Brentjens, Renier, Scheinberg, David A

“…Single-walled carbon nanotubes (CNT) are mechanically robust graphene cylinders with a high aspect ratio that are comprised of sp(2)-bonded carbon atoms and…”
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PET imaging of soluble yttrium-86-labeled carbon nanotubes in mice by McDevitt, Michael R, Chattopadhyay, Debjit, Jaggi, Jaspreet S, Finn, Ronald D, Zanzonico, Pat B, Villa, Carlos, Rey, Diego, Mendenhall, Juana, Batt, Carl A, Njardarson, Jon T, Scheinberg, David A

“…The potential medical applications of nanomaterials are shaping the landscape of the nanobiotechnology field and driving it forward. A key factor in…”
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Fibrillar pharmacology of functionalized nanocellulose by Wong, Sam, Alidori, Simone, Mello, Barbara P., Almeida, Bryan Aristega, Ulmert, David, Brendel, Matthew B., Scheinberg, David A., McDevitt, Michael R.

“…Cellulose nanocrystals (CNC) are linear organic nanomaterials derived from an abundant naturally occurring biopolymer resource. Strategic modification of the…”
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Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer by McDevitt, Michael R., Thorek, Daniel L. J., Hashimoto, Takeshi, Gondo, Tatsuo, Veach, Darren R., Sharma, Sai Kiran, Kalidindi, Teja Muralidhar, Abou, Diane S., Watson, Philip A., Beattie, Bradley J., Timmermand, Oskar Vilhemsson, Strand, Sven-Erik, Lewis, Jason S., Scardino, Peter T., Scher, Howard I., Lilja, Hans, Larson, Steven M., Ulmert, David

“…Human kallikrein peptidase 2 (hK2) is a prostate specific enzyme whose expression is governed by the androgen receptor (AR). AR is the central oncogenic driver…”
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[18F]-Labeled PARP-1 PET imaging of PSMA targeted alpha particle radiotherapy response by Zhang, Hanwen, Abou, Diane, Lu, Peng, Hasson, Abbie Meghan, Villmer, Alexandria, Benabdallah, Nadia, Jiang, Wen, Ulmert, David, Carlin, Sean, Rogers, Buck E., Turtle, Norman F., McDevitt, Michael R., Baumann, Brian, Simons, Brian W., Dehdashti, Farrokh, Zhou, Dong, Thorek, Daniel L. J.

“…The growing interest and clinical translation of alpha particle (α) therapies brings with it new challenges to assess target cell engagement and to monitor…”
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Alpha-Emitting Radionuclides: Current Status and Future Perspectives by Miederer, Matthias, Benešová-Schäfer, Martina, Mamat, Constantin, Kästner, David, Pretze, Marc, Michler, Enrico, Brogsitter, Claudia, Kotzerke, Jörg, Kopka, Klaus, Scheinberg, David A, McDevitt, Michael R

“…The use of radionuclides for targeted endoradiotherapy is a rapidly growing field in oncology. In particular, the focus on the biological effects of different…”
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PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates by Veach, Darren R, Storey, Claire M, Lückerath, Katharina, Braun, Katharina, von Bodman, Christian, Lamminmäki, Urpo, Kalidindi, Teja, Strand, Sven-Erik, Strand, Joanna, Altai, Mohamed, Damoiseaux, Robert, Zanzonico, Pat, Benabdallah, Nadia, Pankov, Dmitry, Scher, Howard I, Scardino, Peter, Larson, Steven M, Lilja, Hans, McDevitt, Michael R, Thorek, Daniel L J, Ulmert, David

“…Most patients with prostate cancer treated with androgen receptor (AR) signaling inhibitors develop therapeutic resistance due to restoration of AR…”
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Deconvoluting hepatic processing of carbon nanotubes by Alidori, Simone, Bowman, Robert L., Yarilin, Dmitry, Romin, Yevgeniy, Barlas, Afsar, Mulvey, J. Justin, Fujisawa, Sho, Xu, Ke, Ruggiero, Alessandro, Riabov, Vladimir, Thorek, Daniel L. J., Ulmert, Hans David S., Brea, Elliott J., Behling, Katja, Kzhyshkowska, Julia, Manova-Todorova, Katia, Scheinberg, David A., McDevitt, Michael R.

“…Single-wall carbon nanotubes present unique opportunities for drug delivery, but have not advanced into the clinic. Differential nanotube accretion and…”
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Carbon nanotubes exhibit fibrillar pharmacology in primates by Alidori, Simone, Thorek, Daniel L J, Beattie, Bradley J, Ulmert, David, Almeida, Bryan Aristega, Monette, Sebastien, Scheinberg, David A, McDevitt, Michael R

“…Nanomedicine rests at the nexus of medicine, bioengineering, and biology with great potential for improving health through innovation and development of new…”
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The Relative Incidence of Anterior Cruciate Ligament Injury in Men and Women at the United States Naval Academy by Gwinn, David E., Wilckens, John H., McDevitt, Edward R., Ross, Glen, Kao, Tzu-Cheg

“…The purpose of this study was to evaluate the relative risk of anterior cruciate ligament injury in female versus male midshipmen at the United States Naval…”
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Tumor Therapy with Targeted Atomic Nanogenerators by McDevitt, Michael R., Ma, Dangshe, Lai, Lawrence T., Simon, Jim, Borchardt, Paul, Frank, R. Keith, Wu, Karen, Pellegrini, Virginia, Curcio, Michael J., Miederer, Matthias, Bander, Neil H., Scheinberg, David A.

“…A single, high linear energy transfer alpha particle can kill a target cell. We have developed methods to target molecular-sized generators of alpha-emitting…”
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Lipid Droplets: A Significant but Understudied Contributor of Host⁻Bacterial Interactions by Libbing, Cassandra L, McDevitt, Adam R, Azcueta, Rea-Mae P, Ahila, Ahila, Mulye, Minal

“…Lipid droplets (LDs) are cytosolic lipid storage organelles that are important for cellular lipid metabolism, energy homeostasis, cell signaling, and…”
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Synthesis and Biodistribution of Oligonucleotide-Functionalized, Tumor-Targetable Carbon Nanotubes by Villa, Carlos H, McDevitt, Michael R, Escorcia, Freddy E, Rey, Diego A, Bergkvist, Magnus, Batt, Carl A, Scheinberg, David A

“…Single-wall carbon nanotubes (SWNT) show promise as nanoscale vehicles for targeted therapies. We have functionalized SWNT using regioselective chemistries to…”
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