Search Results - "Mccullagh, James"

Editorial overview: Recent advances in metabolomics by McCullagh, James S.O., Keun, Hector C.

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Species identification of silks by protein mass spectrometry reveals evidence of wild silk use in antiquity by Lee, Boyoung, Pires, Elisabete, Pollard, A. Mark, McCullagh, James S. O.

“…Silk has been a luxurious commodity throughout modern human history and sericulture has played an important role in ancient global trade as well as…”
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A lipidomic view of SARS-CoV-2 by Ebrahimi, Kourosh H., McCullagh, James S.O.

“…The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which started in late 2019, has caused huge social and economic losses. A…”
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Analysis of oligonucleotides by hydrophilic interaction liquid chromatography coupled to negative ion electrospray ionization mass spectrometry by Gong, Lingzhi, McCullagh, James S.O.

“…Hydrophilic interaction liquid chromatography (HILIC) is here successfully coupled to negative-ion electrospray ionization time-of-flight mass spectrometry…”
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Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors by Reinbold, Raphael, Hvinden, Ingvild C., Rabe, Patrick, Herold, Ryan A., Finch, Alina, Wood, James, Morgan, Melissa, Staudt, Maximillian, Clifton, Ian J., Armstrong, Fraser A., McCullagh, James S. O., Redmond, Jo, Bardella, Chiara, Abboud, Martine I., Schofield, Christopher J.

“…Ivosidenib, an inhibitor of isocitrate dehydrogenase 1 (IDH1) R132C and R132H variants, is approved for the treatment of acute myeloid leukaemia (AML)…”
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Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal by Rack, Johannes Gregor Matthias, Liu, Qiang, Zorzini, Valentina, Voorneveld, Jim, Ariza, Antonio, Honarmand Ebrahimi, Kourosh, Reber, Julia M., Krassnig, Sarah C., Ahel, Dragana, van der Marel, Gijsbert A., Mangerich, Aswin, McCullagh, James S. O., Filippov, Dmitri V., Ahel, Ivan

“…Poly(ADP-ribosyl)ation (PAR) is a versatile and complex posttranslational modification composed of repeating units of ADP-ribose arranged into linear or…”
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Metabolomics reveals diet-derived plant polyphenols accumulate in physiological bone by Alldritt, Isabelle, Whitham-Agut, Beatrice, Sipin, Miguel, Studholme, Jacob, Trentacoste, Angela, Tripp, Jennifer A., Cappai, Maria Grazia, Ditchfield, Peter, Devièse, Thibaut, Hedges, Robert E. M., McCullagh, James S. O.

“…Plant-derived secondary metabolites consumed in the diet, especially polyphenolic compounds, are known to have a range of positive health effects. They are…”
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Isocitrate dehydrogenase gene variants in cancer and their clinical significance by Cadoux-Hudson, Thomas, Schofield, Christopher J, McCullagh, James S O

“…Human isocitrate dehydrogenase (IDH) genes encode for the IDH1, 2 & 3 isoenzymes which catalyse the formation of 2-oxoglutarate from isocitrate and are…”
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Comparing ion-pairing reagents and sample dissolution solvents for ion-pairing reversed-phase liquid chromatography/electrospray ionization mass spectrometry analysis of oligonucleotides by Gong, Lingzhi, McCullagh, James S. O.

“…RATIONALE A sensitive and selective liquid chromatography/mass spectrometry (LC/MS) method is essential for quality control of synthetic oligonucleotides…”
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Ion-Exchange Chromatography Coupled to Mass Spectrometry in Life Science, Environmental, and Medical Research by Ngere, Judith B., Ebrahimi, Kourosh H., Williams, Rachel, Pires, Elisabete, Walsby-Tickle, John, McCullagh, James S. O.

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The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages by Schulthess, Julie, Pandey, Sumeet, Capitani, Melania, Rue-Albrecht, Kevin C., Arnold, Isabelle, Franchini, Fanny, Chomka, Agnieszka, Ilott, Nicholas E., Johnston, Daniel G.W., Pires, Elisabete, McCullagh, James, Sansom, Stephen N., Arancibia-Cárcamo, Carolina V., Uhlig, Holm H., Powrie, Fiona

“…Host microbial cross-talk is essential to maintain intestinal homeostasis. However, maladaptation of this response through microbial dysbiosis or defective…”
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Single amino acid radiocarbon dating of Upper Paleolithic modern humans by Marom, Anat, McCullagh, James S. O., Higham, Thomas F. G., Sinitsyn, Andrey A., Hedges, Robert E. M.

“…Archaeological bones are usually dated by radiocarbon measurement of extracted collagen. However, low collagen content, contamination from the burial…”
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Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism by John, Tobias, Saffoon, Nadia, Walsby-Tickle, John, Hester, Svenja S, Dingler, Felix A, Millington, Christopher L, McCullagh, James S. O, Patel, Ketan J, Hopkinson, Richard J, Schofield, Christopher J

“…Patients with alcoholism and type 2 diabetes manifest altered metabolism, including elevated aldehyde levels and unusually low asparagine levels. We show that…”
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Interferon‐stimulated gene products as regulators of central carbon metabolism by Ebrahimi, Kourosh H., Gilbert‐Jaramillo, Javier, James, William S., McCullagh, James S.O.

“…ISG products are believed to directly block viral replication. We propose an alternative mechanism based on emerging evidence. We discuss that the metabolic…”
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Variants in ALDH1A2 reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis by Zhu, Linyi, Kamalathevan, Pragash, Koneva, Lada A, Zarebska, Jadwiga Miotla, Chanalaris, Anastasios, Ismail, Heba, Wiberg, Akira, Ng, Michael, Muhammad, Hayat, Walsby-Tickle, John, McCullagh, James S O, Watt, Fiona E, Sansom, Stephen N, Furniss, Dominic, Gardiner, Matthew D, Vincent, Tonia L, Riley, Nick, Spiteri, Michelle, McNab, Ian, Little, Christopher, Cogswell, Lucy, Critchley, Paul, Giele, Henk, Shirley, Rebecca

“…More than 40% of individuals will develop osteoarthritis (OA) during their lifetime, yet there are currently no licensed disease-modifying treatments for this…”
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Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1 by Feng, Tianshu, Yamamoto, Atsushi, Wilkins, Sarah E., Sokolova, Elizaveta, Yates, Luke A., Münzel, Martin, Singh, Pooja, Hopkinson, Richard J., Fischer, Roman, Cockman, Matthew E., Shelley, Jake, Trudgian, David C., Schödel, Johannes, McCullagh, James S.O., Ge, Wei, Kessler, Benedikt M., Gilbert, Robert J., Frolova, Ludmila Y., Alkalaeva, Elena, Ratcliffe, Peter J., Schofield, Christopher J., Coleman, Mathew L.

“…Efficient stop codon recognition and peptidyl-tRNA hydrolysis are essential in order to terminate translational elongation and maintain protein sequence…”
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Targeted and Untargeted Metabolic Profiling of Wild Grassland Plants identifies Antibiotic and Anthelmintic Compounds Targeting Pathogen Physiology, Metabolism and Reproduction by French, Katherine E., Harvey, Joe, McCullagh, James S. O.

“…Plants traditionally used by farmers to manage livestock ailments could reduce reliance on synthetic antibiotics and anthelmintics but in many cases their…”
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Trehalose-6-phosphate signaling regulates lateral root formation in Arabidopsis thaliana by Morales-Herrera, Stefania, Jourquin, Joris, Coppé, Frederic, Lopez-Galvis, Lorena, De Smet, Tom, Safi, Alaeddine, Njo, Maria, Griffiths, Cara A, Sidda, John D, Mccullagh, James S O, Xue, Xiaochao, Davis, Benjamin G, Van der Eycken, Johan, Paul, Matthew J, Van Dijck, Patrick, Beeckman, Tom

“…Plant roots explore the soil for water and nutrients, thereby determining plant fitness and agricultural yield, as well as determining ground substructure,…”
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Bioassay-guided isolation of cytotoxic flavonoids from aerial parts of Coronopus didymus by Noreen, Hafiza, Farman, Muhammad, McCullagh, James S.O.

“…Coronopus didymus Linn. (Brassicaceae) is a medicinal plant used traditionally as antipyretic, expectorant, to purify blood and for alleviating symptoms of…”
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Unlocking the organic residues preserved in the corrosion from the Pewsey Hoard vessels by Carvalho, Luciana da Costa, Henry, Richard, McCullagh, James S. O., Pollard, A. Mark

“…The characterization of archaeological metal corrosion has traditionally been limited to the identification of inorganic compounds usually by X-ray diffraction…”
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