Search Results - "Mccomsey, G A"

Markers of inflammation and CD8 T‐cell activation, but not monocyte activation, are associated with subclinical carotid artery disease in HIV‐infected individuals by Longenecker, CT, Funderburg, NT, Jiang, Y, Debanne, S, Storer, N, Labbato, DE, Lederman, MM, McComsey, GA

“…Objectives The aim of the study was to explore the relationships between lymphocyte and monocyte activation, inflammation, and subclinical vascular disease…”
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Insulin resistance and intestinal integrity in children with and without HIV infection in Uganda by Dirajlal‐Fargo, S, Shan, L, Sattar, A, Bowman, E, Gabriel, J, Kulkarni, M, Funderburg, N, Nazzinda, R, Musiime, V, McComsey, GA

“…Objectives The risk of cardiometabolic complications in children with perinatally acquired HIV infection (PHIVs) and in perinatally HIV‐exposed but uninfected…”
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Markers of renal disease and function are associated with systemic inflammation in HIV infection by Gupta, SK, Kitch, D, Tierney, C, Melbourne, K, Ha, B, McComsey, GA

“…Objectives Both renal disease and systemic inflammation predict non‐AIDS‐defining events and overall mortality in HIV‐infected patients. Here, we sought to…”
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Effect of Reducing the Dose of Stavudine on Body Composition, Bone Density, and Markers of Mitochondrial Toxicity in HIV-Infected Subjects: A Randomized, Controlled Study by McComsey, G. A., Re, V. Lo, O'Riordan, M., Walker, U. A., Lebrecht, D., Baron, E., Mounzer, K., Frank, I.

“…Background. Stavudine is widely used in developing countries. Lipoatrophy and mitochondrial toxicity have been linked to stavudine use, but it is unclear…”
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Alcohol and dietary factors associate with gut integrity and inflammation in HIV‐infected adults by Webel, AR, Sattar, A, Funderburg, NT, Kinley, B, Longenecker, CT, Labbato, D, Alam, SM Khurshid, McComsey, GA

“…Objectives HIV‐infected adults have heightened monocyte activation and inflammation, at least partially as a consequence of altered gut integrity. The role of…”
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Vitamin D, osteoprotegerin/receptor activator of nuclear factor‐kappaB ligand (OPG/RANKL) and inflammation with alendronate treatment in HIV‐infected patients with reduced bone mineral density by Natsag, J, Kendall, MA, Sellmeyer, DE, McComsey, GA, Brown, TT

“…Objectives The aim of the study was to determine the effect of alendronate (ALN) on inflammatory markers and osteoprotegerin (OPG)/receptor activator of…”
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Switch to raltegravir decreases soluble CD14 in virologically suppressed overweight women: the Women, Integrase and Fat Accumulation Trial by Lake, JE, McComsey, GA, Hulgan, T, Wanke, CA, Mangili, A, Walmsley, SL, Stramotas, SA, Tracy, R, Currier, JS

“…Objectives Soluble CD14 (sCD14) is a monocyte activation marker associated with increased mortality in HIV infection. We assessed 48‐week changes in sCD14 and…”
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Relationship between total bilirubin and endothelial function, inflammation and oxidative stress in HIV‐infected adults on stable antiretroviral therapy by Hileman, CO, Longenecker, CT, Carman, TL, Milne, GL, Labbato, DE, Storer, NJ, White, CA, McComsey, GA

“…Objectives Enhanced inflammation is evident in HIV infection, even with virological suppression. Outside HIV infection, studies show an independent association…”
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Effects of in utero antiretroviral exposure on mitochondrial DNA levels, mitochondrial function and oxidative stress by Ross, AC, Leong, T, Avery, A, Castillo‐Duran, M, Bonilla, H, Lebrecht, D, Walker, UA, Storer, N, Labbato, D, Khaitan, A, Tomanova‐Soltys, I, McComsey, GA

“…Objectives HIV and antiretroviral (ART) exposure in utero may have deleterious effects on the infant, but uncertainty still exists. The objective of this study…”
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Uridine supplementation in HIV lipoatrophy: pilot trial on safety and effect on mitochondrial indices by McComsey, G.A, O'Riordan, M, Setzer, B, Lebrecht, D, Baron, E, Walker, U.A

“…Objectives: Uridine abrogates mitochondrial toxicities of nucleoside reverse transcriptase inhibitor in adipocyte cell culture. We aim to study the effect of…”
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Summaries for patients. Nonnucleoside reverse transcriptase inhibitor-sparing antiretroviral regimens for treatment-naive volunteers infected with HIV-1 by Lennox, J L, Landovitz, R J, Ribaudo, H J, Ofotokun, I, Na, L H, Godfrey, C, Kuritzkes, D R, Sagar, M, Brown, T T, Cohn, S E, McComsey, G A, Aweeka, F, Fichtenbaum, C J, Presti, R M, Koletar, S L, Haas, D W, Patterson, K B, Benson, C A, Baugh, B P, Leavitt, R Y, Rooney, J F, Seekins, D, Currier, J S

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Metabolic complications of HIV therapy in children by MCCOMSEY, Grace A, LEONAR, Ethan

“…The implementation of potent antiretroviral therapy (ART) in combination regimens has profoundly decreased mortality and disease progression in patients…”
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Lipoprotein‐associated phospholipase A2 and cardiovascular disease risk in HIV infection by Ross Eckard, A, Longenecker, CT, Jiang, Y, Debanne, SM, Labbato, D, Storer, N, McComsey, GA

“…Objectives HIV‐infected patients on antiretroviral therapy (ART) have an increased cardiovascular disease (CVD) risk as a result of heightened inflammation and…”
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Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine by McComsey, Grace A, Paulsen, Denise M, Lonergan, J Tyler, Hessenthaler, Siegrid M, Hoppel, Charles L, Williams, Vanessa C, Fisher, Robin L, Cherry, Catherine L, White-Owen, Cathy, Thompson, Katherine A, Ross, Steve T, Hernandez, Jaime E, Ross, Lisa L

“…To determine if stavudine (alpha4T)-associated mitochondrial toxicity could be reversed by substitution with another nucleoside reverse transcriptase…”
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Health State Utilities of Risks Associated with Antiretroviral Treatment for Human Immunodeficiency Virus (Hiv) by Matza, LS, Chung, KC, Kim, KJ, Paulus, T, Davies, EW, Stewart, KD, McComsey, GA, Fordyce, M

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Dendritic cell recruitment in response to skin antigen tests in HIV-1-infected individuals correlates with the level of T-cell infiltration by LIANG, Frank, BOND, Emily, ANDERSSON, Jan, LORE, Karin, SANDGREN, Kerrie J, SMED-SÖRENSEN, Anna, RANGAKA, Molebogeng X, LANGE, Christoph, KOUP, Richard A, MCCOMSEY, Grace A, LEDERMAN, Michael M, WILKINSON, Robert J

“…To study whether in-vivo recruitment of dendritic cells in response to antigen administration in the skin is altered during HIV-1 infection. Skin punch…”
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Impaired glucose tolerance in HIV-infected patients by Madhun, Z T, Arafah, B M, McComsey, G A

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Lipid Oxidative Markers Are Significantly Increased in Lipoatrophy But Not in Sustained Asymptomatic Hyperlactatemia by McComsey, Grace A, Morrow, Jason D

“…The exact mechanism of lipoatrophy remains unclear. One hypothesized mechanism is accumulation of reactive oxygen free radicals, which is possibly related to…”
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Effect of 24 Weeks of Statin Therapy on Systemic and Vascular Inflammation in HIV-Infected Subjects Receiving Antiretroviral Therapy by Eckard, Allison Ross, Jiang, Ying, Debanne, Sara M., Funderburg, Nicholas T., McComsey, Grace A.

“…Background. Human immunodeficiency virus (HIV)-infected individuals are at increased risk of cardiovascular disease (CVD) due in part to inflammation. Statins…”
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Higher subclinical cardiac fibrosis in South African youth with HIV: results from the CTAAC-heart study by Jao, J, Zar, H J, Kahts, M, Jermy, S, Nyathi, M, Asafu-Agyei, N, Legbedze, J, Carkeek, E, Mautsa, T, Bonner, L B, Mccomsey, G A, Feinstein, M, Kurland, I J, Myer, L B, Ntusi, N

“…Abstract Background Few data exist on cardiac fibrosis and inflammation in youth with HIV, particularly in sub-Saharan Africa. Purpose Our objective was to…”
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