Search Results - "Mccarthy, Derrick P"

A Biodegradable Nanoparticle Platform for the Induction of Antigen-Specific Immune Tolerance for Treatment of Autoimmune Disease by Hunter, Zoe, McCarthy, Derrick P, Yap, Woon Teck, Harp, Christopher T, Getts, Daniel R, Shea, Lonnie D, Miller, Stephen D

“…Targeted immune tolerance is a coveted therapy for the treatment of a variety of autoimmune diseases, as current treatment options often involve nonspecific…”
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Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice by Carrero, Javier A., McCarthy, Derrick P., Ferris, Stephen T., Wan, Xiaoxiao, Hu, Hao, Zinselmeyer, Bernd H., Vomund, Anthony N., Unanue, Emil R.

“…Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor resulted in depletion of the resident macrophages of pancreatic islets of…”
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Exploiting apoptosis for therapeutic tolerance induction by Getts, Daniel R, McCarthy, Derrick P, Miller, Stephen D

“…Immune tolerance remains the most promising yet elusive strategy for treating immune-mediated diseases. An experimental strategy showing promise in phase 1…”
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Have we overestimated the benefit of human(ized) antibodies? by Getts, Daniel R., Getts, Meghann T., McCarthy, Derrick P., Chastain, Emily ML, Miller, Stephen D.

“…The infusion of animal-derived antibodies has been known for some time to trigger the generation of antibodies directed at the foreign protein as well as…”
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Oligodendrocyte death results in immune-mediated CNS demyelination by Traka, Maria, Podojil, Joseph R, McCarthy, Derrick P, Miller, Stephen D, Popko, Brian

“…Oligodendrocyte death in the DTA mouse model leads to a fatal, secondary demyelinating disease associated with CNS T cell infiltration and myelin…”
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Mouse models of multiple sclerosis: experimental autoimmune encephalomyelitis and Theiler's virus-induced demyelinating disease by McCarthy, Derrick P, Richards, Maureen H, Miller, Stephen D

“…Experimental autoimmune encephalomyelitis (EAE) and Theiler's Murine Encephalitis Virus-Induced Demyelinating Disease (TMEV-IDD) are two clinically relevant…”
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Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis by Getts, Daniel R, Martin, Aaron J, McCarthy, Derrick P, Terry, Rachael L, Hunter, Zoe N, Yap, Woon Teck, Getts, Meghann Teague, Pleiss, Michael, Luo, Xunrong, King, Nicholas JC, Shea, Lonnie D, Miller, Stephen D

“…Microparticles coated with encephalitogenic peptides are effective at treating multiple sclerosis in a mouse model. Aberrant T-cell activation underlies many…”
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An antigen-encapsulating nanoparticle platform for TH1/17 immune tolerance therapy by McCarthy, Derrick P., Yap, Jonathan Woon-Teck, Harp, Christopher T., Song, W. Kelsey, Chen, Jeane, Pearson, Ryan M., Miller, Stephen D., Shea, Lonnie D.

“…Tolerogenic nanoparticles (NPs) are rapidly being developed as specific immunotherapies to treat autoimmune disease. However, many NP-based therapies conjugate…”
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Tolerance induction using nanoparticles bearing HY peptides in bone marrow transplantation by Hlavaty, Kelan A, McCarthy, Derrick P, Saito, Eiji, Yap, Woon Teck, Miller, Stephen D, Shea, Lonnie D

“…Abstract Allogeneic cell therapies have either proven effective or have great potential in numerous applications, though the required systemic, life-long…”
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Targeted immunomodulation using antigen-conjugated nanoparticles by McCarthy, Derrick P., Hunter, Zoe N., Chackerian, Bryce, Shea, Lonnie D., Miller, Stephen D.

“…ABSTRACT The growing prevalence of nanotechnology in the fields of biology, medicine, and the pharmaceutical industry is confounded by the relatively small…”
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Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis by Getts, Daniel R, Martin, Aaron J, Mccarthy, Derrick P, Terry, Rachael L, Hunter, Zoe N, Yap, Woon Teck, Getts, Meghann Teague, Pleiss, Michael, Luo, Xunrong, King, Nicholas J C, Shea, Lonnie D, Miller, Stephen D

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Abstract 893: A chimeric PD1-CD28 switch receptor enhances the activity of TRuC-T cells by McCarthy, Derrick P., Guyette, Sarah, Lofgren, Michael, Sethuraman, Jyothi, DeSilva, Thamara, Aziz, Ahmar, Patterson, Troy, Datari, Shruti, Chan, Tiffany, Kieffer-Kwon, Philippe, Rold, Christopher J., Singh, Reshma, Ding, Jian, Horton, Holly, Barnitz, R. Anthony, Cornforth, Andrew, Tighe, Robert, Hofmeister, Robert J., Gutierrez, Dario A.

“…Abstract Cluster of differentiation 28 (CD28) and programmed death receptor 1 (PD-1) are members of the CD28 superfamily of co-receptors that have critical…”
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An antigen-encapsulating nanoparticle platform for TH 1/17 immune tolerance therapy by McCarthy, Derrick P., PhD, Yap, Jonathan Woon-Teck, PhD, Harp, Christopher T., PhD, Song, W. Kelsey, BS, Chen, Jeane, PhD, Pearson, Ryan M., PhD, Miller, Stephen D., PhD, Shea, Lonnie D., PhD

“…Abstract Tolerogenic nanoparticles (NPs) are rapidly being developed as specific immunotherapies to treat autoimmune disease. However, many NP-based therapies…”
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Erratum: Corrigendum: Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis by Getts, Daniel R, Martin, Aaron J, McCarthy, Derrick P, Terry, Rachael L, Hunter, Zoe N, Yap, Woon Teck, Getts, Meghann Teague, Pleiss, Michael, Luo, Xunrong, King, Nicholas J C, Shea, Lonnie D, Miller, Stephen D

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Corrigendum: microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis by Getts, Daniel R, Martin, Aaron J, McCarthy, Derrick P, Terry, Rachael L, Hunter, Zoe N, Yap, Woon Teck, Getts, Meghann Teague, Pleiss, Michael, Luo, Xunrong, King, Nicholas J.C, Shea, Lonnie D, Miller, Stephen D

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Correction: Corrigendum: Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis by Getts, Daniel R, Martin, Aaron J, McCarthy, Derrick P, Terry, Rachael L, Hunter, Zoe N, Yap, Woon Teck, Getts, Meghann Teague, Pleiss, Michael, Luo, Xunrong, King, Nicholas J C, Shea, Lonnie D, Miller, Stephen D

“…Nat. Biotechnol. 30, 1217–1224 (2012); published online 18 November 2012; corrected after print 30 May 2013 In the version of this article initially published,…”
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An antigen-encapsulating nanoparticle platform for T H 1/17 immune tolerance therapy by McCarthy, Derrick P, Yap, Jonathan Woon-Teck, Harp, Christopher T, Song, W Kelsey, Chen, Jeane, Pearson, Ryan M, Miller, Stephen D, Shea, Lonnie D

“…Tolerogenic nanoparticles (NPs) are rapidly being developed as specific immunotherapies to treat autoimmune disease. However, many NP-based therapies conjugate…”
Get full text