Search Results - "Mccarren, Hilary"

Comparison of neuropathology in rats following status epilepticus induced by diisopropylfluorophosphate and soman by Rojas, Asheebo, McCarren, Hilary S., Wang, Jennifer, Wang, Wenyi, Abreu-Melon, JuanMartin, Wang, Sarah, McDonough, John H., Dingledine, Raymond

“…[Display omitted] •Electrographic status epilepticus is similar for rats administered soman and DFP.•Neuroinflammation and gliosis is lower after soman-induced…”
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The Kv7 Modulator, Retigabine, is an Efficacious Antiseizure Drug for Delayed Treatment of Organophosphate-induced Status Epilepticus by Barker, Bryan S., Spampanato, Jay, McCarren, Hilary S., Berger, Kyle, Jackson, Cecelia E., Yeung, David T., Dudek, F. Edward, McDonough, John H.

“…•The Kv7 channel agonist retigabine is a novel treatment option for OP-induced SE.•Retigabine with and without MDZ, attenuated electrographic seizure…”
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Screening for Efficacious Anticonvulsants and Neuroprotectants in Delayed Treatment Models of Organophosphate-induced Status Epilepticus by Barker, Bryan S., Spampanato, Jay, McCarren, Hilary S., Smolik, Melissa, Jackson, Cecelia E., Hornung, Eden N., Yeung, David T., Dudek, F. Edward, McDonough, John H.

“…•The CNS program screens for novel adjunct therapies in two delayed treatment models of OP-induced status epilepticus.•Neurosteroids appear to be the most…”
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Validating a model of benzodiazepine refractory nerve agent-induced status epilepticus by evaluating the anticonvulsant and neuroprotective effects of scopolamine, memantine, and phenobarbital by Jackson, Cecelia, Ardinger, Cherish, Winter, Kristin M., McDonough, John H., McCarren, Hilary S.

“…Organophosphorus nerve agents (OPNAs) irreversibly block acetylcholinesterase activity, resulting in accumulation of excess acetylcholine at neural synapses,…”
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Distinctive Recruitment of Endogenous Sleep-promoting Neurons by Volatile Anesthetics and a Nonimmobilizer by Han, Bo, McCarren, Hilary S, O’Neill, Dan, Kelz, Max B

“…BACKGROUND:Numerous studies demonstrate that anesthetic-induced unconsciousness is accompanied by activation of hypothalamic sleep-promoting neurons, which…”
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Dexmedetomidine stops benzodiazepine-refractory nerve agent-induced status epilepticus by McCarren, Hilary S., Arbutus, Julia A., Ardinger, Cherish, Dunn, Emily N., Jackson, Cecelia E., McDonough, John H.

“…•Nerve agent-induced status epilepticus becomes refractory to midazolam.•Combined therapy with dexmedetomidine and midazolam stops status…”
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Mouse behavioral endophenotypes for schizophrenia by Amann, Laura C, Gandal, Michael J, Halene, Tobias B, Ehrlichman, Richard S, White, Samantha L, McCarren, Hilary S, Siegel, Steven J

“…Abstract An endophenotype is a heritable trait that is generally considered to be more highly, associated with a gene-based neurological deficit than a disease…”
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Anticonvulsant discovery through animal models of status epilepticus induced by organophosphorus nerve agents and pesticides by McCarren, Hilary S., McDonough Jr, John H.

“…Organophosphorus pesticides (OPs) and nerve agents (NAs) are highly toxic chemicals that pose a significant threat to human health worldwide. These compounds…”
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α2-Adrenergic stimulation of the ventrolateral preoptic nucleus destabilizes the anesthetic state by McCarren, Hilary S, Chalifoux, Michael R, Han, Bo, Moore, Jason T, Meng, Qing Cheng, Baron-Hionis, Nina, Sedigh-Sarvestani, Madineh, Contreras, Diego, Beck, Sheryl G, Kelz, Max B

“…The sleep-promoting ventrolateral preoptic nucleus (VLPO) shares reciprocal inhibitory inputs with wake-active neuronal nuclei, including the locus ceruleus…”
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Refractory and Super-Refractory Status Epilepticus in Nerve Agent-Poisoned Rats Following Application of Standard Clinical Treatment Guidelines by Morgan, Julia E., Wilson, Sara C., Travis, Benjamin J., Bagri, Kathryn H., Pagarigan, Kathleen T., Belski, Hannah M., Jackson, Cecelia, Bounader, Kevin M., Coppola, Jessica M., Hornung, Eden N., Johnson, James E., McCarren, Hilary S.

“…Nerve agents (NAs) induce a severe cholinergic crisis that can lead to status epilepticus (SE). Current guidelines for treatment of NA-induced SE only include…”
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alpha 2-Adrenergic Stimulation of the Ventrolateral Preoptic Nucleus Destabilizes the Anesthetic State by McCarren, Hilary S, Chalifoux, Michael R, Han, Bo, Moore, Jason T, Meng, Qing Cheng, Baron-Hionis, Nina, Sedigh-Sarvestani, Madineh, Contreras, Diego, Beck, Sheryl G, Kelz, Max B

“…The sleep-promoting ventrolateral preoptic nucleus (VLPO) shares reciprocal inhibitory inputs with wake-active neuronal nuclei, including the locus ceruleus…”
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Enaminone Modulators of Extrasynaptic α4β3δ γ-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning by Johnstone, Timothy B. C., McCarren, Hilary S., Spampanato, Jay, Dudek, F. Edward, McDonough, John H., Hogenkamp, Derk, Gee, Kelvin W.

“…Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic…”
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The synthetic neuroactive steroid SGE-516 reduces status epilepticus and neuronal cell death in a rat model of soman intoxication by Althaus, Alison L, McCarren, Hilary S, Alqazzaz, Aymen, Jackson, Cecelia, McDonough, John H, Smith, Carl D, Hoffman, Ethan, Hammond, Rebecca S, Robichaud, Albert J, Doherty, James J

“…Abstract Organophosphorus nerve agents (OPNAs) are irreversible inhibitors of acetylcholinesterase that pose a serious threat to public health because of their…”
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The role of genetic background in susceptibility to chemical warfare nerve agents across rodent and non-human primate models by Matson, Liana M., McCarren, Hilary S., Cadieux, C. Linn, Cerasoli, Douglas M., McDonough, John H.

“…Genetics likely play a role in various responses to nerve agent exposure, as genetic background plays an important role in behavioral, neurological, and…”
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Characterization and treatment of spontaneous recurrent seizures following nerve agent-induced status epilepticus in mice by McCarren, Hilary S., Eisen, Margaret R., Nguyen, Dominique L., Dubée, Parker B., Ardinger, Cherish E., Dunn, Emily N., Haines, Kari M., Santoro, Antonia N., Bodner, Paige M., Ondeck, Celinia A., Honnold, Cary L., McDonough, John H., Beske, Phillip H., McNutt, Patrick M.

“…•Soman-induced SE led to recurrent seizures in all mice with minimal latency.•Seizure burden varied considerably between mice.•Lesions were restricted to the…”
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Evaluation of fosphenytoin, levetiracetam, and propofol as treatments for nerve agent-induced seizures in pediatric and adult rats by Dunn, Emily N., Matson, Liana M., Haines, Kari M., Whitten, Kimberly A., Lee-Stubbs, Robyn B., Berger, Kyle E., McCarren, Hilary S., Ardinger, Cherish E., Jackson Piercy, Cecelia E., Miller-Smith, Stephanie M., McDonough, John H.

“…•Male and female immature and adult rats were exposed to the nerve agents sarin or VX to elicit status epilepticus (SE) seizures.•The animals were treated with…”
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Disinhibition of histaminergic neurons: lack of effect on arousal switch following propofol hypnosis by Weiser, Brian P, McCarren, Hilary S

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Assessing changes in volatile general anesthetic sensitivity of mice after local or systemic pharmacological intervention by McCarren, Hilary S, Moore, Jason T, Kelz, Max B

“…One desirable endpoint of general anesthesia is the state of unconsciousness, also known as hypnosis. Defining the hypnotic state in animals is less…”
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Developing a Prenatal Acute Exposure and Medical Countermeasure Evaluation Model for Organophosphate Compounds in a Genetically Modified Mouse by Herrera, Eric, Barry, Timothy, Sriraman, Aishwarya, Brecht, Karen, DeBus, Sandra, Ma, Ki, Mccarren, Hilary, Cadieux, C. L.

“…Organophosphate (OPs) compounds make up the most common class of pesticides as well as chemical warfare nerve agents (CWNA), all of which covalently inhibit…”
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Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats by Matson, Liana, Dunn, Emily, Haines, Kari, Miller-Smith, Stephanie, Lee-Stubbs, Robyn, Whitten, Kimberly, Ardinger, Cherish, McCarren, Hilary, McDonough, John

“…•Median effective doses (ED50) were determined for diazepam and midazolam in pediatric and adult rats against nerve agent-induced seizures.•Midazolam and…”
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