Search Results - "Mcardle, L."

Systematic identification of genetic influences on methylation across the human life course by Gaunt, Tom R, Shihab, Hashem A, Hemani, Gibran, Min, Josine L, Woodward, Geoff, Lyttleton, Oliver, Zheng, Jie, Duggirala, Aparna, McArdle, Wendy L, Ho, Karen, Ring, Susan M, Evans, David M, Davey Smith, George, Relton, Caroline L

“…The influence of genetic variation on complex diseases is potentially mediated through a range of highly dynamic epigenetic processes exhibiting temporal…”
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Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) by Richmond, Rebecca C, Simpkin, Andrew J, Woodward, Geoff, Gaunt, Tom R, Lyttleton, Oliver, McArdle, Wendy L, Ring, Susan M, Smith, Andrew D A C, Timpson, Nicholas J, Tilling, Kate, Davey Smith, George, Relton, Caroline L

“…Maternal smoking during pregnancy has been found to influence newborn DNA methylation in genes involved in fundamental developmental processes. It is pertinent…”
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The epigenetic clock and physical development during childhood and adolescence: longitudinal analysis from a UK birth cohort by Simpkin, Andrew J, Howe, Laura D, Tilling, Kate, Gaunt, Tom R, Lyttleton, Oliver, McArdle, Wendy L, Ring, Susan M, Horvath, Steve, Smith, George Davey, Relton, Caroline L

“…Statistical models that use an individual's DNA methylation levels to estimate their age (known as epigenetic clocks) have recently been developed, with 96%…”
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The effects of NICE guidelines on the management of third molar teeth by McArdle, L. W., Renton, T.

“…Key Points Highlights that third molar removal is as common now as it was before the introduction of clinical guidelines. Informs that NICE guidelines have…”
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DNA Methylation and BMI: Investigating Identified Methylation Sites at HIF3A in a Causal Framework by Richmond, Rebecca C, Sharp, Gemma C, Ward, Mary E, Fraser, Abigail, Lyttleton, Oliver, McArdle, Wendy L, Ring, Susan M, Gaunt, Tom R, Lawlor, Debbie A, Davey Smith, George, Relton, Caroline L

“…Multiple differentially methylated sites and regions associated with adiposity have now been identified in large-scale cross-sectional studies. We tested for…”
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Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility by Domingues, Francisco S, Vermeire, Séverine, Rutgeerts, Paul, Franke, Andre, Sina, Christian, Rosenstiel, Philip, Wijmenga, Cisca, Sventoraityte, Jurgita, Mayr, Gabriele, Karlsen, Tom H, Nikolaus, Susanna, Balschun, Tobias, Mathew, Christopher G, Stokkers, Pieter C F, Schreiber, Stefan, Albrecht, Mario, Vatn, Morten H, Onnie, Clive M, Ellinghaus, David, Gazouli, Maria, Strachan, David, Nothnagel, Michael, McArdle, Wendy L, Weersma, Rinse K, Krawczak, Michael

“…Inflammatory bowel disease (IBD) typically manifests as either ulcerative colitis (UC) or Crohn's disease (CD). Systematic identification of susceptibility…”
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Differences in smoking associated DNA methylation patterns in South Asians and Europeans by Elliott, Hannah R, Tillin, Therese, McArdle, Wendy L, Ho, Karen, Duggirala, Aparna, Frayling, Tim M, Davey Smith, George, Hughes, Alun D, Chaturvedi, Nish, Relton, Caroline L

“…DNA methylation is strongly associated with smoking status at multiple sites across the genome. Studies have largely been restricted to European origin…”
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Characteristics of disease related to mesio-angular mandibular third molar teeth by McArdle, L.W., Jones, J., McDonald, F.

“…The aim of this study was to identify the indications for the removal of mesio-angular mandibular third molars based on age and dental health as measured by…”
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A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order by Ramasamy, Adaikalavan, DPhil, Curjuric, Ivan, MD, Coin, Lachlan J., DPhil, Kumar, Ashish, MSc, McArdle, Wendy L., PhD, Imboden, Medea, PhD, Leynaert, Benedicte, PhD, Kogevinas, Manolis, MD, Schmid-Grendelmeier, Peter, MD, Pekkanen, Juha, MD, Wjst, Matthias, MD, Bircher, Andreas J., MD, Sovio, Ulla, PhD, Rochat, Thierry, MD, Hartikainen, Anna-Liisa, MD, Balding, David J., DPhil, Jarvelin, Marjo-Riitta, MD, Probst-Hensch, Nicole, PhD, Strachan, David P., MD, Jarvis, Deborah L., MD

“…Background Hay fever or seasonal allergic rhinitis (AR) is a chronic disorder associated with IgE sensitization to grass. The underlying genetic variants have…”
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Diseases associated with mandibular third molar teeth by McArdle, L. W., Andiappan, M., Khan, I., Jones, J., McDonald, F.

“…Key Points Provides awareness of the change in third molar disease as a consequence of NICE Guidance. Highlights that an increase in caries is an indication…”
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Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 ( IL17REL ) by Franke, Andre, Balschun, Tobias, Sina, Christian, Ellinghaus, David, Häsler, Robert, Mayr, Gabriele, Albrecht, Mario, Wittig, Michael, Buchert, Eva, Nikolaus, Susanna, Gieger, Christian, Wichmann, H Erich, Sventoraityte, Jurgita, Kupcinskas, Limas, Onnie, Clive M, Gazouli, Maria, Anagnou, Nicholas P, Strachan, David, McArdle, Wendy L, Mathew, Christopher G, Rutgeerts, Paul, Vermeire, Séverine, Vatn, Morten H, Krawczak, Michael, Rosenstiel, Philip, Karlsen, Tom H, Schreiber, Stefan

“…We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new…”
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Expure and Bonding of Unerupted Posterior Teeth by Patel, V, Johal, N, McArdle, L, McDonald, F

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β2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study by Hall, Ian P, Blakey, John D, Al Balushi, Khalid A, Wheatley, Amanda, Sayers, Ian, Pembrey, Marcus E, Ring, Susan M, McArdle, Wendy L, Strachan, David P

“…Functionally relevant polymorphisms of the β2-adrenoceptor gene ( ADRB2) are common in white populations, but their contribution to the burden of airways…”
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Epidemiology of dengue and dengue hemorrhagic fever in a cohort of adults living in Bandung, West Java, Indonesia by Porter, Kevin R, Beckett, Charmagne G, Kosasih, Herman, Tan, Ratna Irsiana, Alisjahbana, Bachti, Rudiman, Pandji Irani Fianza, Widjaja, Susana, Listiyaningsih, Erlin, Ma'Roef, Chairin Nisa, McArdle, James L, Parwati, Ida, Sudjana, Primal, Jusuf, Hadi, Yuwono, Djoko, Wuryadi, Suharyono

“…A prospective study of dengue fever (DF) and dengue hemorrhagic fever (DHF) was conducted in a cohort of adult volunteers from two textile factories located in…”
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An academic home by McArdle, L

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Association of IL13 with total IgE: Evidence against an inverse association of atopy and diabetes by Maier, Lisa M., Howson, Joanna M.M., Walker, Neil, Spickett, Gavin P., Jones, Richard W., Ring, Susan M., McArdle, Wendy L., Lowe, Christopher E., Bailey, Rebecca, Payne, Felicity, Todd, John A., Strachan, David P.

“…Atopic illnesses, related to high circulating IgE levels, and the autoimmune disease type 1 diabetes, have been reported to be inversely associated. One…”
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Prenatal and early life influences on epigenetic age in children: a study of mother-offspring pairs from two cohort studies by Simpkin, Andrew J, Hemani, Gibran, Suderman, Matthew, Gaunt, Tom R, Lyttleton, Oliver, Mcardle, Wendy L, Ring, Susan M, Sharp, Gemma C, Tilling, Kate, Horvath, Steve, Kunze, Sonja, Peters, Annette, Waldenberger, Melanie, Ward-Caviness, Cavin, Nohr, Ellen A, Sørensen, Thorkild I A, Relton, Caroline L, Smith, George Davey

“…DNA methylation-based biomarkers of aging are highly correlated with actual age. Departures of methylation-estimated age from actual age can be used to define…”
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Lack of association of MYO9B genetic variants with coeliac disease in a British cohort by Hunt, K A, Monsuur, A J, McArdle, W L, Kumar, P J, Travis, S P L, Walters, J R F, Jewell, D P, Strachan, D P, Playford, R J, Wijmenga, C, van Heel, D A

“…Background and aims: Development of coeliac disease involves an interaction between environmental factors (especially dietary wheat, rye, and barley antigens)…”
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Influenza Surveillance in Indonesia: 1999–2003 by Beckett, Charmagne G., Kosasih, Herman, Ma'roef, Chairin, Listiyaningsih, Erlin, Elyazar, Iqbal R. F., Wuryadi, Suharyono, Yuwono, Djoko, McArdle, James L., Corwin, Andrew L., Porter, Kevin R.

“…Although influenza is recognized for its worldwide importance, little is known about the disease from tropical countries like Indonesia. From August 1999…”
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Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci by McCauley, Jacob L., Zuvich, Rebecca L., Beecham, Ashley H., De Jager, Philip L., Konidari, Ioanna, Whitehead, Patrice L., Aubin, Cristin, Ban, Maria, Pobywajlo, Susan, Briskin, Rebeccah, Romano, Susan, Aggarwal, Neelum T., Piccio, Laura, McArdle, Wendy L., Strachan, David P., Evans, Denis, Cross, Anne H., Cree, Bruce, Rioux, John D., Barcellos, Lisa F., Ivinson, Adrian J., Compston, Alastair, Hafler, David A., Hauser, Stephen L., Oksenberg, Jorge R., Sawcer, Stephen J., Pericak-Vance, Margaret A., Haines, Jonathan L.

“…Genome-wide association studies (GWASs) have proven highly effective, identifying hundreds of associations across numerous complex diseases. These studies…”
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