Search Results - "McVey, John H"

Heme oxygenase (HO)-1 induction prevents Endoplasmic Reticulum stress-mediated endothelial cell death and impaired angiogenic capacity by Maamoun, Hatem, Zachariah, Matshediso, McVey, John H., Green, Fiona R., Agouni, Abdelali

“…[Display omitted] Most of diabetic cardiovascular complications are attributed to endothelial dysfunction and impaired angiogenesis. Endoplasmic Reticulum (ER)…”
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Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant by McIntosh, Jenny, Lenting, Peter J., Rosales, Cecilia, Lee, Doyoung, Rabbanian, Samira, Raj, Deepak, Patel, Nishil, Tuddenham, Edward G.D., Christophe, Olivier D., McVey, John H., Waddington, Simon, Nienhuis, Arthur W., Gray, John T., Fagone, Paolo, Mingozzi, Federico, Zhou, Shang-Zhen, High, Katherine A., Cancio, Maria, Ng, Catherine Y.C., Zhou, Junfang, Morton, Christopher L., Davidoff, Andrew M., Nathwani, Amit C.

“…Recombinant adeno-associated virus (rAAV) vectors encoding human factor VIII (hFVIII) were systematically evaluated for hemophilia A (HA) gene therapy. A…”
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Neointimal hyperplasia after endoluminal injury in mice is dependent on tissue factor- and angiopoietin-2 dependent interferon gamma production by fibrocytes and macrophages by Chen, Daxin, Li, Ke, Wei, Lin-Lin, Ma, Ning, McVey, John H, Dorling, Anthony

“…The intimal hyperplasia (IH) and vascular remodelling that follows endovascular injury, for instance after post-angioplasty re-stenosis, results in downstream…”
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Clustered F8 missense mutations cause hemophilia A by combined alteration of splicing and protein biosynthesis and activity by Donadon, Irving, McVey, John H, Garagiola, Isabella, Branchini, Alessio, Mortarino, Mimosa, Peyvandi, Flora, Bernardi, Francesco, Pinotti, Mirko

“…Dissection of pleiotropic effects of missense mutations, rarely investigated in inherited diseases, is fundamental to understanding genotype-phenotype…”
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Pericytes' Circadian Clock Affects Endothelial Cells' Synchronization and Angiogenesis in a 3D Tissue Engineered Scaffold by Mastrullo, Valeria, van der Veen, Daan R, Gupta, Priyanka, Matos, Rolando S, Johnston, Jonathan D, McVey, John H, Madeddu, Paolo, Velliou, Eirini G, Campagnolo, Paola

“…Angiogenesis, the formation of new capillaries from existing ones, is a fundamental process in regenerative medicine and tissue engineering. While it is known…”
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Codon optimization of human factor VIII cDNAs leads to high-level expression by Ward, Natalie J., Buckley, Suzanne M.K., Waddington, Simon N., VandenDriessche, Thierry, Chuah, Marinee K.L., Nathwani, Amit C., McIntosh, Jenny, Tuddenham, Edward G.D., Kinnon, Christine, Thrasher, Adrian J., McVey, John H.

“…Gene therapy for hemophilia A would be facilitated by development of smaller expression cassettes encoding factor VIII (FVIII), which demonstrate improved…”
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Manipulation of tissue factor-mediated basal PAR-2 signalling on macrophages determines sensitivity for IFNγ responsiveness and significantly modifies the phenotype of murine DTH by Wilkinson, Hannah, Leonard, Hugh, Robson, Michael G., Smith, Richard, Tam, ElLi, McVey, John H., Kirckhofer, Daniel, Chen, Daxin, Dorling, Anthony

“…Background Tissue factor (TF) generates proteases that can signal through PAR-1 and PAR-2. We have previously demonstrated PAR-1 signalling primes innate…”
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Hyperactive PiggyBac Transposons for Sustained and Robust Liver-targeted Gene Therapy by Di Matteo, Mario, Samara-Kuko, Emira, Ward, Natalie J, Waddingon, Simon N, McVey, John H, Chuah, Marinee KL, VandenDriessche, Thierry

“…The development of robust nonviral vectors could facilitate clinical gene therapy applications and may overcome some of the immune complications of viral…”
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Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer by Alba, Raul, Bradshaw, Angela C., Parker, Alan L., Bhella, David, Waddington, Simon N., Nicklin, Stuart A., van Rooijen, Nico, Custers, Jerome, Goudsmit, Jaap, Barouch, Dan H., McVey, John H., Baker, Andrew H.

“…Recent studies have demonstrated the importance of coagulation factor X (FX) in adenovirus (Ad) serotype 5–mediated liver transduction in vivo. FX binds to the…”
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Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes by Parker, Alan L., Waddington, Simon N., Nicol, Campbell G., Shayakhmetov, Dmitry M., Buckley, Suzanne M., Denby, Laura, Kemball-Cook, Geoffrey, Ni, Shaoheng, Lieber, Andre, McVey, John H., Nicklin, Stuart A., Baker, Andrew H.

“…Upon local delivery, adenovirus (Ad) serotype 5 viruses use the coxsackie and Ad receptor (CAR) for cell binding and αv integrins for internalization. When…”
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Age-Dependent Decline in Common Femoral Artery Flow-Mediated Dilation and Wall Shear Stress in Healthy Subjects by Bapir, Mariam, Untracht, Gavrielle R, Hunt, Julie E A, McVey, John H, Harris, Jenny, Skene, Simon S, Campagnolo, Paola, Dikaios, Nikolaos, Rodriguez-Mateos, Ana, Sampson, David D, Sampson, Danuta M, Heiss, Christian

“…Femoral artery (FA) endothelial function is a promising biomarker of lower extremity vascular health for peripheral artery disease (PAD) prevention and…”
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Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo by Ma, Jiangtao, Duffy, Margaret R, Deng, Lin, Dakin, Rachel S, Uil, Taco, Custers, Jerome, Kelly, Sharon M, McVey, John H, Nicklin, Stuart A, Baker, Andrew H

“…Adenoviruses are common pathogens, mostly targeting ocular, gastrointestinal and respiratory cells, but in some cases infection disseminates, presenting in…”
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Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors by Alba, Raul, Bradshaw, Angela C., Coughlan, Lynda, Denby, Laura, McDonald, Robert A., Waddington, Simon N., Buckley, Suzanne M.K., Greig, Jenny A., Parker, Alan L., Miller, Ashley M., Wang, Hongjie, Lieber, Andre, van Rooijen, Nico, McVey, John H., Nicklin, Stuart A., Baker, Andrew H.

“…A major limitation for adenoviral transduction in vivo is the profound liver tropism of adenovirus type 5 (Ad5). Recently, we demonstrated that coagulation…”
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3D Printed Bioreactor Enabling the Pulsatile Culture of Native and Angioplastied Large Arteries by Matos, Rolando S, Maselli, Davide, McVey, John H, Heiss, Christian, Campagnolo, Paola

“…Routine interventions such as balloon angioplasty, result in vascular activation and remodeling, often requiring re-intervention. models and small animal…”
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PAR-1 signaling on macrophages is required for effective in vivo delayed-type hypersensitivity responses by Wilkinson, Hannah, Leonard, Hugh, Chen, Daxin, Lawrence, Toby, Robson, Michael, Goossens, Pieter, McVey, John H., Dorling, Anthony

“…Delayed-type hypersensitivity (DTH) responses underpin chronic inflammation. Using a model of oxazolone-induced dermatitis and a combination of transgenic…”
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Inhibition of Angiopoietin-2 Production by Myofibrocytes Inhibits Neointimal Hyperplasia After Endoluminal Injury in Mice by Chen, Daxin, Li, Ke, Tham, El-Li, Wei, Lin-Lin, Ma, Ning, Dodd, Philippa C, Luo, Yi, Kirchhofer, Daniel, McVey, John H, Dorling, Anthony

“…Fibrocytes are myeloid lineage cells implicated in wound healing, repair, and fibrosis. We previously showed that fibrocytes are mobilized into the circulation…”
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Regression of Atherosclerosis in ApoE-/- Mice Via Modulation of Monocyte Recruitment and Phenotype, Induced by Weekly Dosing of a Novel "Cytotopic" Anti-Thrombin Without Prolonged Anticoagulation by Chen, Daxin, Li, Ke, Festenstein, Sam, Karegli, Julieta, Wilkinson, Hannah, Leonard, Hugh, Wei, Lin-Lin, Ma, Ning, Xia, Min, Tam, Henry, Wang, Jian-An, Xu, Qingbo, McVey, John H, Smith, Richard A G, Dorling, Anthony

“…Background Anticoagulants induce atherosclerosis regression in animal models but exploiting this clinically is limited by bleeding events. Here we test a novel…”
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Protease‐activated receptor‐2 signalling by tissue factor on dendritic cells suppresses antigen‐specific CD4+ T‐cell priming by Shrivastava, Seema, Ma, Liang, Tham, El‐Li, H. McVey, John, Chen, Daxin, Dorling, Anthony

“…Summary The precise function of tissue factor (TF) expressed by dendritic cells (DC) is uncertain. As well as initiating thrombin generation it can signal…”
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A Cluster of Basic Amino Acids in the Factor X Serine Protease Mediates Surface Attachment of Adenovirus/FX Complexes by DUFFY, Margaret R, BRADSHAW, Angela C, PARKER, Alan L, MCVEY, John H, BAKER, Andrew H

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Effect of Neutralizing Sera on Factor X-Mediated Adenovirus Serotype 5 Gene Transfer by PARKER, Alan L, WADDINGTON, Simon N, BUCKLEY, Suzanne M. K, CUSTERS, Jerome, HAVENGA, Menzo J. E, VAN ROOIJEN, Nico, GOUDSMIT, Jaap, MCVEY, John H, NICKLIN, Stuart A, BAKER, Andrew H

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