Search Results - "McVerry, Bryan"

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 by Gordon, Anthony C, Mouncey, Paul R, Al-Beidh, Farah, Rowan, Kathryn M, Nichol, Alistair D, Arabi, Yaseen M, Annane, Djillali, Beane, Abi, van Bentum-Puijk, Wilma, Berry, Lindsay R, Bhimani, Zahra, Bonten, Marc J M, Bradbury, Charlotte A, Brunkhorst, Frank M, Buzgau, Adrian, Cheng, Allen C, Detry, Michelle A, Duffy, Eamon J, Estcourt, Lise J, Fitzgerald, Mark, Goossens, Herman, Haniffa, Rashan, Higgins, Alisa M, Hills, Thomas E, Horvat, Christopher M, Lamontagne, Francois, Lawler, Patrick R, Leavis, Helen L, Linstrum, Kelsey M, Litton, Edward, Lorenzi, Elizabeth, Marshall, John C, Mayr, Florian B, McAuley, Daniel F, McGlothlin, Anna, McGuinness, Shay P, McVerry, Bryan J, Montgomery, Stephanie K, Morpeth, Susan C, Murthy, Srinivas, Orr, Katrina, Parke, Rachael L, Parker, Jane C, Patanwala, Asad E, Pettilä, Ville, Rademaker, Emma, Santos, Marlene S, Saunders, Christina T, Seymour, Christopher W, Shankar-Hari, Manu, Sligl, Wendy I, Turgeon, Alexis F, Turner, Anne M, van de Veerdonk, Frank L, Zarychanski, Ryan, Green, Cameron, Lewis, Roger J, Angus, Derek C, McArthur, Colin J, Berry, Scott, Webb, Steve A, Derde, Lennie P G

“…The interleukin-6 receptor blockers tocilizumab and sarilumab were tested against standard care in a randomized trial involving patients newly admitted to the…”
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Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial by Matthay, Michael A, Calfee, Carolyn S, Zhuo, Hanjing, Thompson, B Taylor, Wilson, Jennifer G, Levitt, Joseph E, Rogers, Angela J, Gotts, Jeffrey E, Wiener-Kronish, Jeanine P, Bajwa, Ednan K, Donahoe, Michael P, McVerry, Bryan J, Ortiz, Luis A, Exline, Matthew, Christman, John W, Abbott, Jason, Delucchi, Kevin L, Caballero, Lizette, McMillan, Melanie, McKenna, David H, Liu, Kathleen D

“…Treatment with bone-marrow-derived mesenchymal stromal cells (MSCs) has shown benefits in preclinical models of acute respiratory distress syndrome (ARDS)…”
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The Lung Microbiome in Hematopoietic Stem Cell Transplant. Where the Money Lies by McVerry, Bryan J, Morris, Alison

“…[...]changes observed in the human lung were not the same as those seen in the murine model. [...]the function of resident microbes is likely to have an effect…”
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Effect of Convalescent Plasma on Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial by Estcourt, Lise J, Turgeon, Alexis F, McQuilten, Zoe K, McVerry, Bryan J, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen M, Arnold, Donald M, Beane, Abigail, Bégin, Philippe, van Bentum-Puijk, Wilma, Berry, Lindsay R, Bhimani, Zahra, Birchall, Janet E, Bonten, Marc J. M, Bradbury, Charlotte A, Brunkhorst, Frank M, Buxton, Meredith, Callum, Jeannie L, Chassé, Michaël, Cheng, Allen C, Cove, Matthew E, Daly, James, Derde, Lennie, Detry, Michelle A, De Jong, Menno, Evans, Amy, Fergusson, Dean A, Fish, Matthew, Fitzgerald, Mark, Foley, Claire, Goossens, Herman, Gordon, Anthony C, Gosbell, Iain B, Green, Cameron, Haniffa, Rashan, Harvala, Heli, Higgins, Alisa M, Hills, Thomas E, Hoad, Veronica C, Horvat, Christopher, Huang, David T, Hudson, Cara L, Ichihara, Nao, Laing, Emma, Lamikanra, Abigail A, Lamontagne, François, Lawler, Patrick R, Linstrum, Kelsey, Litton, Edward, Lorenzi, Elizabeth, MacLennan, Sheila, Marshall, John, McAuley, Daniel F, McDyer, John F, McGlothlin, Anna, McGuinness, Shay, Miflin, Gail, Montgomery, Stephanie, Mouncey, Paul R, Murthy, Srinivas, Nichol, Alistair, Parke, Rachael, Parker, Jane C, Priddee, Nicole, Purcell, Damian F. J, Reyes, Luis F, Richardson, Peter, Robitaille, Nancy, Rowan, Kathryn M, Rynne, Jennifer, Saito, Hiroki, Santos, Marlene, Saunders, Christina T, Serpa Neto, Ary, Seymour, Christopher W, Silversides, Jon A, Tinmouth, Alan A, Triulzi, Darrell J, Turner, Anne M, van de Veerdonk, Frank, Walsh, Timothy S, Wood, Erica M, Berry, Scott, Lewis, Roger J, Menon, David K, McArthur, Colin, Zarychanski, Ryan, Angus, Derek C, Webb, Steve A, Roberts, David J, Shankar-Hari, Manu

“…IMPORTANCE: The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive. OBJECTIVE: To determine whether…”
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Perceived utility of electrodiagnostic testing in critical illness myopathy and polyneuropathy: A survey of intensive care unit providers by Isfort, Michael, McVerry, Bryan J., Shutter, Lori, Kim, Minji, Lacomis, David

“…Introduction/Aims Critical illness myopathy (CIM) and critical illness polyneuropathy (CIP) are common disorders associated with substantial morbidity…”
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Metagenomic identification of severe pneumonia pathogens in mechanically-ventilated patients: a feasibility and clinical validity study by Yang, Libing, Haidar, Ghady, Zia, Haris, Nettles, Rachel, Qin, Shulin, Wang, Xiaohong, Shah, Faraaz, Rapport, Sarah F, Charalampous, Themoula, Methé, Barbara, Fitch, Adam, Morris, Alison, McVerry, Bryan J, O'Grady, Justin, Kitsios, Georgios D

“…Metagenomic sequencing of respiratory microbial communities for pathogen identification in pneumonia may help overcome the limitations of culture-based…”
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Respiratory Tract Dysbiosis Is Associated with Worse Outcomes in Mechanically Ventilated Patients by Kitsios, Georgios D, Yang, Haopu, Yang, Libing, Qin, Shulin, Fitch, Adam, Wang, Xiao-Hong, Fair, Katherine, Evankovich, John, Bain, William, Shah, Faraaz, Li, Kelvin, Methé, Barbara, Benos, Panayiotis V, Morris, Alison, McVerry, Bryan J

“…Host inflammatory responses have been strongly associated with adverse outcomes in critically ill patients, but the biologic underpinnings of such…”
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Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non–Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial by Berger, Jeffrey S, Kornblith, Lucy Z, Gong, Michelle N, Reynolds, Harmony R, Cushman, Mary, Cheng, Yu, McVerry, Bryan J, Kim, Keri S, Lopes, Renato D, Atassi, Bassel, Berry, Scott, Bochicchio, Grant, de Oliveira Antunes, Murillo, Farkouh, Michael E, Greenstein, Yonatan, Hade, Erinn M, Hudock, Kristin, Hyzy, Robert, Khatri, Pooja, Kindzelski, Andrei, Kirwan, Bridget-Anne, Baumann Kreuziger, Lisa, Lawler, Patrick R, Leifer, Eric, Lopez-Sendon Moreno, Jose, Lopez-Sendon, Jose, Luther, James F, Nigro Maia, Lilia, Quigley, John, Sherwin, Robert, Wahid, Lana, Wilson, Jennifer, Hochman, Judith S, Neal, Matthew D

“…IMPORTANCE: Platelets represent a potential therapeutic target for improved clinical outcomes in patients with COVID-19. OBJECTIVE: To evaluate the benefits…”
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Aging Mesenchymal Stem Cells Fail to Protect Because of Impaired Migration and Antiinflammatory Response by BUSTOS, Martha L, HULEIHEL, Luai, MORA, Ana L, ROJAS, Mauricio, KAPETANAKI, Maria G, LINO-CARDENAS, Christian L, MROZ, Lyle, ELLIS, Bryon M, MCVERRY, Bryan J, RICHARDS, Thomas J, KAMINSKI, Naftali, CERDENES, Nayra

“…Aging is characterized by functional impairment and reduced capacity to respond appropriately to environmental stimuli and injury. With age, there is an…”
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Circulating microbial cell-free DNA is associated with inflammatory host-responses in severe pneumonia by Yang, Haopu, Haidar, Ghady, Al-Yousif, Nameer S, Zia, Haris, Kotok, Daniel, Ahmed, Asim A, Blair, Lily, Dalai, Sudeb, Bercovici, Sivan, Ho, Carine, McVerry, Bryan J, Morris, Alison, Kitsios, Georgios D

“…Host inflammatory responses predict worse outcome in severe pneumonia, yet little is known about what drives dysregulated inflammation. We performed…”
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Severe Acute Respiratory Syndrome Coronavirus 2 Viremia Is Associated With Coronavirus Disease 2019 Severity and Predicts Clinical Outcomes by Jacobs, Jana L, Bain, William, Naqvi, Asma, Staines, Brittany, Castanha, Priscila M S, Yang, Haopu, Boltz, Valerie F, Barratt-Boyes, Simon, Marques, Ernesto T A, Mitchell, Stephanie L, Methé, Barbara, Olonisakin, Tolani F, Haidar, Ghady, Burke, Thomas W, Petzold, Elizabeth, Denny, Thomas, Woods, Chris W, McVerry, Bryan J, Lee, Janet S, Watkins, Simon C, St Croix, Claudette M, Morris, Alison, Kearney, Mary F, Ladinsky, Mark S, Bjorkman, Pamela J, Kitsios, Georgios D, Mellors, John W

“…Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA (vRNA) is detected in the bloodstream of some patients with…”
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Association of the systemic host immune response with acute hyperglycemia in mechanically ventilated septic patients by Farooq, Nauman, Chuan, Byron, Mahmud, Hussain, El Khoudary, Samar R, Nouraie, Seyed Mehdi, Evankovich, John, Yang, Libing, Dunlap, Daniel, Bain, William, Kitsios, Georgios, Zhang, Yingze, O'Donnell, Christopher P, McVerry, Bryan J, Shah, Faraaz Ali

“…Hyperglycemia during sepsis is associated with increased organ dysfunction and higher mortality. The role of the host immune response in development of…”
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A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation by Chen, Bill B, Coon, Tiffany A, Glasser, Jennifer R, McVerry, Bryan J, Zhao, Jing, Zhao, Yutong, Zou, Chunbin, Ellis, Bryon, Sciurba, Frank C, Zhang, Yingze, Mallampalli, Rama K

“…Inflammation needs to be tightly regulated to avoid immunopathology. Mallampalli and colleagues show that a system of F box proteins tunes proinflammatory…”
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Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis by Lai, Yandong, Li, Xiuying, Li, Tiao, Li, Xiaoyun, Nyunoya, Toru, Chen, Kong, Kitsios, Georgios, Nouraie, Mehdi, Zhang, Yingze, McVerry, Bryan J, Lee, Janet S, Mallmapalli, Rama K, Zou, Chunbin

“…One hallmark of sepsis is the reduced number of lymphocytes, termed lymphopenia, that occurs from decreased lymphocyte proliferation or increased cell death…”
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No evidence of hemoglobin damage by SARS-CoV-2 infection by DeMartino, Anthony W, Rose, Jason J, Amdahl, Matthew B, Dent, Matthew R, Shah, Faraaz A, Bain, William, McVerry, Bryan J, Kitsios, Georgios D, Tejero, Jesús, Gladwin, Mark T

“…SARS-CoV-2 disease (COVID-19) has affected over 22 million patients worldwide as of August 2020. As the medical community seeks better understanding of the…”
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The Renin-Angiotensin System in Acute Lung Injury by Lawler, Patrick R., Derde, Lennie P. G., McVerry, Bryan J., Russell, James A., van de Veerdonk, Frank L.

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Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19 by Goligher, Ewan C, Lawler, Patrick R, Jensen, Thomas P, Talisa, Victor, Berry, Lindsay R, Lorenzi, Elizabeth, McVerry, Bryan J, Chang, Chung-Chou Ho, Leifer, Eric, Bradbury, Charlotte, Berger, Jeffrey, Hunt, Beverly J, Castellucci, Lana A, Kornblith, Lucy Z, Gordon, Anthony C, McArthur, Colin, Webb, Steven, Hochman, Judith, Neal, Matthew D, Zarychanski, Ryan, Berry, Scott, Angus, Derek C

“…IMPORTANCE: Randomized clinical trials (RCTs) of therapeutic-dose heparin in patients hospitalized with COVID-19 produced conflicting results, possibly due to…”
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Dysbiosis in the intensive care unit: Microbiome science coming to the bedside by Kitsios, Georgios D, Morowitz, Michael J, Dickson, Robert P, Huffnagle, Gary B., McVerry, Bryan J, Morris, Alison

“…Complex microbial communities within the human body, constituting the microbiome, have a broad impact on human health and disease. A growing body of research…”
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Host-Microbiome Interactions in the Subglottic Space. Bacteria Ante Portas by Kitsios, Georgios D, McVerry, Bryan J

“…Neutrophil impairment was reversed with mucolytic (dithiothreitol) treatment, thereby demonstrating direct immunomodulation by airway mucin. [...]in intubated…”
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Neutrophils and galectin-3 defend mice from lethal bacterial infection and humans from acute respiratory failure by Das, Sudipta, Kaminski, Tomasz W., Schlegel, Brent T., Bain, William, Hu, Sanmei, Patel, Akruti, Kale, Sagar L., Chen, Kong, Lee, Janet S., Mallampalli, Rama K., Kagan, Valerian E., Rajasundaram, Dhivyaa, McVerry, Bryan J., Sundd, Prithu, Kitsios, Georgios D., Ray, Anuradha, Ray, Prabir

“…Respiratory infection by Pseudomonas aeruginosa , common in hospitalized immunocompromised and immunocompetent ventilated patients, can be life-threatening…”
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