Search Results - "McStay, G P"

Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways by McStay, G P, Salvesen, G S, Green, D R

“…Caspases orchestrate the controlled demise of a cell after an apoptotic signal through specific protease activity and cleavage of many substrates altering…”
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The permeability transition pore complex: another view by Halestrap, Andrew P, McStay, Gavin P, Clarke, Samantha J

“…Mitochondria play a critical role in initiating both apoptotic and necrotic cell death. A major player in this process is the mitochondrial permeability…”
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Sanglifehrin A Acts as a Potent Inhibitor of the Mitochondrial Permeability Transition and Reperfusion Injury of the Heart by Binding to Cyclophilin-D at a Different Site from Cyclosporin A by Clarke, Samantha J, McStay, Gavin P, Halestrap, Andrew P

“…Cyclosporin A (CsA) inhibits opening of the mitochondrial permeability transition pore (MPTP), a critical event in some forms of necrotic and apoptotic cell…”
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Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore by McStay, Gavin P, Clarke, Samantha J, Halestrap, Andrew P

“…Opening of the mitochondrial permeability transition pore (MPTP) is sensitized to [Ca(2+)] by oxidative stress (diamide) and phenylarsine oxide (PAO). We have…”
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In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis by Beere, Helen M, Green, Douglas R, Tu, Shine, McStay, Gavin P, Boucher, Louis-Martin, Mak, Tak

“…Activation of 'initiator' (or 'apical') caspases-2, -8 or -9 (refs 1-3) is crucial for induction of apoptosis. These caspases function to activate executioner…”
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