Search Results - "McRitchie, Susan"

Moderate-to-Vigorous Physical Activity From Ages 9 to 15 Years by Nader, Philip R, Bradley, Robert H, Houts, Renate M, McRitchie, Susan L, O’Brien, Marion

“…CONTEXT Decreased physical activity plays a critical role in the increase in childhood obesity. Although at least 60 minutes per day of moderate-to-vigorous…”
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Multi-omics analysis of glucose-mediated signaling by a moonlighting Gβ protein Asc1/RACK1 by Li, Shuang, Li, Yuanyuan, Rushing, Blake R., Harris, Sarah E., McRitchie, Susan L., Jones, Janice C., Dominguez, Daniel, Sumner, Susan J., Dohlman, Henrik G.

“…Heterotrimeric G proteins were originally discovered through efforts to understand the effects of hormones, such as glucagon and epinephrine, on glucose…”
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Metabolomics Analysis of Hormone-Responsive and Triple-Negative Breast Cancer Cell Responses to Paclitaxel Identify Key Metabolic Differences by Stewart, Delisha A, Winnike, Jason H, McRitchie, Susan L, Clark, Robert F, Pathmasiri, Wimal W, Sumner, Susan J

“…To date, no targeted therapies are available to treat triple negative breast cancer (TNBC), while other breast cancer subtypes are responsive to current…”
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Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice by Livanos, Alexandra E., Greiner, Thomas U., Vangay, Pajau, Pathmasiri, Wimal, Stewart, Delisha, McRitchie, Susan, Li, Huilin, Chung, Jennifer, Sohn, Jiho, Kim, Sara, Gao, Zhan, Barber, Cecily, Kim, Joanne, Ng, Sandy, Rogers, Arlin B., Sumner, Susan, Zhang, Xue-Song, Cadwell, Ken, Knights, Dan, Alekseyenko, Alexander, Bäckhed, Fredrik, Blaser, Martin J.

“…The early life microbiome plays important roles in host immunological and metabolic development. Because the incidence of type 1 diabetes (T1D) has been…”
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Correlated metabolomic, genomic, and histologic phenotypes in histologically normal breast tissue by Sun, Xuezheng, Stewart, Delisha A, Sandhu, Rupninder, Kirk, Erin L, Pathmasiri, Wimal W, McRitchie, Susan L, Clark, Robert F, Troester, Melissa A, Sumner, Susan J

“…Breast carcinogenesis is a multistep process accompanied by widespread molecular and genomic alterations, both in tumor and in surrounding microenvironment. It…”
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Untargeted metabolomics reveal signatures of a healthy lifestyle by Pathmasiri, Wimal, Rushing, Blake R., McRitchie, Susan, Choudhari, Mansi, Du, Xiuxia, Smirnov, Alexsandr, Pelleigrini, Matteo, Thompson, Michael J., Sakaguchi, Camila A., Nieman, David C., Sumner, Susan J.

“…This cross-sectional study investigated differences in the plasma metabolome in two groups of adults that were of similar age but varied markedly in body…”
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Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function by Sandlers, Yana, Mercier, Kelly, Pathmasiri, Wimal, Carlson, Jim, McRitchie, Susan, Sumner, Susan, Vernon, Hilary J

“…Barth Syndrome is the only known Mendelian disorder of cardiolipin remodeling, with characteristic clinical features of cardiomyopathy, skeletal myopathy, and…”
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Exploring the internal exposome of seminal plasma with semen quality and live birth: A Pilot Study by Houle, Emily, Li, YuanYuan, Schroder, Madison, McRitchie, Susan L, Rahil, Tayyab, Sites, Cynthia K, Jenkins Sumner, Susan, Pilsner, J. Richard

“…Infertility is clinically defined as the inability to achieve pregnancy within 12 months of regular unprotected sexual intercourse and affects 15% of couples…”
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A Metabolomics Approach to Investigate Kukoamine B-A Potent Natural Product With Anti-diabetic Properties by Li, Yuan-Yuan, Stewart, Delisha A, Ye, Xiao-Min, Yin, Li-Hua, Pathmasiri, Wimal W, McRitchie, Susan L, Fennell, Timothy R, Cheung, Hon-Yeung, Sumner, Susan J

“…Due to the surge in type 2 diabetes mellitus (T2DM), treatments for chronic metabolic dysregulations with fewer side-effects are sought. Lycii Cortex (LyC), a…”
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Chemical exposures assessed via silicone wristbands and endogenous plasma metabolomics during pregnancy by Doherty, Brett T., McRitchie, Susan L., Pathmasiri, Wimal W., Stewart, Delisha A., Kirchner, David, Anderson, Kim A., Gui, Jiang, Madan, Juliette C., Hoen, Anne G., Sumner, Susan J., Karagas, Margaret R., Romano, Megan E.

“…Background Metabolomics is a promising method to investigate physiological effects of chemical exposures during pregnancy, with the potential to clarify…”
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Multi-Omics Analysis of Multiple Glucose-Sensing Receptor Systems in Yeast by Li, Shuang, Li, Yuanyuan, Rushing, Blake R, Harris, Sarah E, McRitchie, Susan L, Dominguez, Daniel, Sumner, Susan J, Dohlman, Henrik G

“…The yeast has long been used to produce alcohol from glucose and other sugars. While much is known about glucose metabolism, relatively little is known about…”
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Untargeted metabolomics on first trimester serum implicates metabolic perturbations associated with BMI in development of hypertensive disorders: a discovery study by Li, Yuanyuan, Pan, Ke, McRitchie, Susan L, Harville, Emily W, Sumner, Susan C J

“…Body mass index (BMI) in early pregnancy is a critical risk factor for hypertensive disorders of pregnancy (HDP). The pathobiology of the interplay between BMI…”
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Serum trace metal association with response to erythropoiesis stimulating agents in incident and prevalent hemodialysis patients by Brier, Michael E., Gooding, Jessica R., Harrington, James M., Burgess, Jason P., McRitchie, Susan L., Zhang, Xiaolan, Rovin, Brad H., Klein, Jon B., Himmelfarb, Jonathan, Sumner, Susan J., Merchant, Michael L.

“…Alterations in hemodialysis patients’ serum trace metals have been documented. Early studies addressing associations levels of serum trace metals with…”
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Pretreatment with indomethacin results in increased heat stroke severity during recovery in a rodent model of heat stroke by Audet, Gerald N, Dineen, Shauna M, Stewart, Delisha A, Plamper, Mark L, Pathmasiri, Wimal W, McRitchie, Susan L, Sumner, Susan J, Leon, Lisa R

“…It has been suggested that medications can increase heat stroke (HS) susceptibility/severity. We investigated whether the nonsteroidal anti-inflammatory drug…”
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Sex-Specific Metabolic Effects of Dietary Folate Withdrawal in Wild-Type and Aldh1l1 Knockout Mice by Sharma, Jaspreet, Rushing, Blake R, Hall, Madeline S, Helke, Kristi L, McRitchie, Susan L, Krupenko, Natalia I, Sumner, Susan J, Krupenko, Sergey A

“…ALDH1L1 (10-formyltetrahydrofolate dehydrogenase), an enzyme of folate metabolism, is highly expressed in the liver. It regulates the overall flux of…”
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EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain by Rock, Kylie D, Horman, Brian, Phillips, Allison L, McRitchie, Susan L, Watson, Scott, Deese-Spruill, Jocelin, Jima, Dereje, Sumner, Susan, Stapleton, Heather M, Patisaul, Heather B

“…Firemaster 550 (FM 550) is a flame retardant (FR) mixture that has become one of the most commonly used FRs in foam-based furniture and baby products. Human…”
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Macronutrient-differential dietary pattern impacts on body weight, hepatic inflammation, and metabolism by Li, Yuan-Yuan, Madduri, Supradeep S, Rezeli, Erika T, Santos, Charlene, Freeman Iii, Herman, Peng, Jing, McRitchie, Susan L, Pathmasiri, Wimal, Hursting, Stephen D, Sumner, Susan J, Stewart, Delisha A

“…Obesity is a multi-factorial disease frequently associated with poor nutritional habits and linked to many detrimental health outcomes. Individuals with…”
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Metabolites as biomarkers of adverse reactions following vaccination: A pilot study using nuclear magnetic resonance metabolomics by McClenathan, Bruce M, Stewart, Delisha A, Spooner, Christina E, Pathmasiri, Wimal W, Burgess, Jason P, McRitchie, Susan L, Choi, Y. Sammy, Sumner, Susan C.J

“…Highlights • Metabolomics is the study of the small-molecule metabolite profile of an organism. • Metabolomics may help identify individuals predisposed to…”
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Early life exposure to vitamin D deficiency impairs molecular mechanisms that regulate liver cholesterol biosynthesis, energy metabolism, inflammation, and detoxification by Knuth, Megan M, Xue, Jing, Elnagheeb, Marwa, Gharaibeh, Raad Z, Schoenrock, Sarah A, McRitchie, Susan, Brouwer, Cory, Sumner, Susan J, Tarantino, Lisa, Valdar, William, Rector, R Scott, Simon, Jeremy M, Ideraabdullah, Folami

“…Emerging data suggests liver disease may be initiated during development when there is high genome plasticity and the molecular pathways supporting liver…”
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Metabolomics reveals biomarkers of opioid use disorder by Ghanbari, Reza, Li, Yuanyuan, Pathmasiri, Wimal, McRitchie, Susan, Etemadi, Arash, Pollock, Jonathan D., Poustchi, Hossein, Rahimi-Movaghar, Afarin, Amin-Esmaeili, Masoumeh, Roshandel, Gholamreza, Shayanrad, Amaneh, Abaei, Behrouz, Malekzadeh, Reza, Sumner, Susan C. J.

“…Opioid use disorder (OUD) is diagnosed using the qualitative criteria defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition…”
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