Search Results - "McReynolds, Matthew D."

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1 by Schnute, Mark E, McReynolds, Matthew D, Kasten, Tom, Yates, Matthew, Jerome, Gina, Rains, John W, Hall, Troii, Chrencik, Jill, Kraus, Michelle, Cronin, Ciaran N, Saabye, Matthew, Highkin, Maureen K, Broadus, Richard, Ogawa, Shinji, Cukyne, Kristin, Zawadzke, Laura E, Peterkin, Vincent, Iyanar, Kaliapan, Scholten, Jeffrey A, Wendling, Jay, Fujiwara, Hideji, Nemirovskiy, Olga, Wittwer, Arthur J, Nagiec, Marek M

“…SphK (sphingosine kinase) is the major source of the bioactive lipid and GPCR (G-protein-coupled receptor) agonist S1P (sphingosine 1-phosphate). S1P promotes…”
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Synthesis of Phosphorus and Sulfur Heterocycles via Ring-Closing Olefin Metathesis by McReynolds, Matthew D, Dougherty, Joseph M, Hanson, Paul R

“…Organophosphorus compounds continue to receive widespread attention due to their ubiquity in biological systems and their potential to serve as novel…”
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Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits by Schnute, Mark E, McReynolds, Matthew D, Carroll, Jeffrey, Chrencik, Jill, Highkin, Maureen K, Iyanar, Kaliapan, Jerome, Gina, Rains, John W, Saabye, Matthew, Scholten, Jeffrey A, Yates, Matthew, Nagiec, Marek M

“…Sphingosine kinase (SphK) is the major source of the lipid mediator and G protein-coupled receptor agonist sphingosine-1-phosphate (S1P). S1P promotes cell…”
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(+)-Saxitoxin:  A First and Second Generation Stereoselective Synthesis by Fleming, James J, McReynolds, Matthew D, Du Bois, J

“…A stereoselective synthesis of the bis-guanidinium toxin (+)-saxitoxin (STX), the agent infamously associated with red tides and paralytic shellfish poisoning,…”
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A Temporary Phosphorus Tether/Ring-Closing Metathesis Strategy to Functionalized 1,4-Diamines by Sprott, Kevin T, McReynolds, Matthew D, Hanson, Paul R

“…The synthesis of 1,4-diamines containing the (Z)-1,4-diaminobut-2-ene subunit via a temporary phosphorus tether/RCM strategy is described. We have developed a…”
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Multivalent Activation in Temporary Phosphate Tethers:  A New Tether for Small Molecule Synthesis by Whitehead, Alan, McReynolds, Matthew D, Moore, Joel D, Hanson, Paul R

“…A new tether for small molecule synthesis is reported. This functionally active tether mediates the desymmetrization of a pseudo-C 2-symmetric tris-allylic…”
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Multivalent Activation in Temporary Phosphate Tethers:  A New Tether for Small Molecule Synthesis by Whitehead, Alan, McReynolds, Matthew D, Moore, Joel D, Hanson, Paul R

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A Concise Route to Structurally Diverse DMP 323 Analogues via Highly Functionalized 1,4-Diamines by McReynolds, Matthew D, Sprott, Kevin T, Hanson, Paul R

“…The utility of functionalized 1,4-diamines, produced via a temporary phosphorus tether (P-tether)/ring-closing metathesis (RCM)/hydrolysis sequence, is…”
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A new process to prepare 3,6-dichloro-2-hydroxybenzoic acid, the penultimate intermediate in the synthesis of herbicide dicamba by Walker, Daniel P., Harris, G. Davis, Carroll, Jeffery N., Boehm, Terri L., McReynolds, Matthew D., Struble, Justin R., van Herpt, Jochem, van Zwieten, Don, Koeller, Kevin J., Bore, Mangesh

“…[Display omitted] •3,6-Dichloro-2-hydroxybenzoic acid (3,6-DCSA) can be prepared in four steps from salicylic acid.•3,6-DCSA can be prepared without the need…”
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Metathesis studies to cyclic enol phosphonamidates by Sieck, Stephen R., McReynolds, Matthew D., Schroeder, Chad E., Hanson, Paul R.

“…The development of cyclic, six membered enol phosphonamidates utilizing the ring-closing metathesis (RCM) reaction is discussed. Phosphonamidic monochloridates…”
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Ring-Closing Metathesis Strategies to P -heterocycles by Sprott, Kevin T., McReynolds, Matthew D., Hanson, Paul R.

“…A general approach to the synthesis of P -heterocycles using the ring-closing metathesis reaction is described. We have developed a new method utilizing…”
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